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Nicotine and Other Tobacco Compounds in Neurodegenerative and Psychiatric Diseases: Epidemiological Data on Smoking and Preclinical and Clinical Data on Nicotine provides a comprehensive summary of the epidemiological data on smoking and several neurological disorders, including Alzheimer's disease, Parkinson's disease, Multiple Sclerosis, Tourette's syndrome, schizophrenia, anxiety, depression and ADHD, as well as preclinical and clinical data on the effects of nicotine. Despite the obvious and undisputed harmful nature of smoking, evidence suggests that some tobacco and tobacco smoke-derived constituents may offer neuroprotective effects, possibly in combinations, rather than individually. This unprecedented book describes the complex relationships between smoking and neurological disease and the bioactive compounds found in tobacco. It provides a comprehensive review of nicotine and other compounds found in tobacco plant, with scientific evidence of neuroprotective and anti-inflammatory effects that may act in conjunction with nicotine to exert neuroprotective effects observed in smokers. By presenting findings beyond harmful cigarette smoke effects, attention can be drawn to individual compounds of tobacco that may serve as inspiration for further therapy development.

Neuropathology --- Nicotine addiction --- Treatment.

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Nicotine addiction --- Treatment.

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PointsReferences; Chapter 2: Maternal Smoking and Fetal Brain Outcome: Mechanisms and Possible Solutions; 2.1. Introduction; 2.2. Maternal Smoking and Brain Development; 2.3. Maternal Smoking and Neurocognitive Outcome; 2.4. Maternal Smoking and HI Encephalopathy; 2.5. Potential Mechanisms; 2.5.1. Brain Inflammatory Response; 2.5.2. Brain Oxidative Stress; 2.5.2.1. ROS; 2.5.2.2. Antioxidant Defense System; 2.5.3. Mitochondrial Function and Integrity; 2.5.3.1. Mitochondrial Membrane Functional Units; 2.5.3.2. Mitochondrial Integrity; 2.5.3.2.1. Fission Machinery.

Nicotine. --- Nicotine --- Tobacco Use Disorder. --- Physiological effect. --- Psychological aspects.

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Nicotine addiction. --- Tobacco use. --- Tobacco habit --- Habit --- Substance abuse --- Nicotine addiction --- Cigarette habit --- Nicotine dependence --- Tobacco addiction --- Tobacco dependence --- Drug addiction --- Tobacco use

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This book is a guide to pharmacotherapy treatment of tobacco dependence. The 2020 American Thoracic Society clinical practice guidelines on treating tobacco dependence serves as the cornerstone for this work with its robust discussion of recommended treatment options and how to tailor treatment to specific patient populations. Tobacco dependence remains a major health concern for many adults and given the dramatic increase of youth electronic cigarette use, clinicians need a singular resource to treat these different populations. This book addresses that by following the three main points of how to best address the adverse impact of tobacco use on public health: 1) prevent initiation of tobacco use; 2) understand mechanisms of addiction; 3) effectively treat tobacco dependence. The book begins by describing the current patterns of product use, the adverse impact of tobacco on global health, and tobacco-related health disparities. Authors discuss both combustible and electronic tobacco products, as well as current research on the adverse impact of vaping and associated flavorings including menthol, role of the e-cigarette in cessation, and treatment of adolescent nicotine dependence. Chapters conclude with a discussion of specific tobacco control policies to improve overall public health. This is an ideal guide for pulmonologists, pediatricians, primary care physicians and other specialty providers who see patients with nicotine dependence. This book is also of interest to public health professions to help inform public health campaigns and treatment offerings to reduce overall tobacco product use through prevention and treatment.

Respiratory organs—Diseases. --- Pneumology. --- Nicotine addiction --- Tobacco use --- Treatment. --- Prevention.