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"Neuroblastoma: Molecular Mechanisms and Therapeutic Interventions comprehensively reviews current concepts in molecular and histopathological mechanisms that influence the growth of human malignant neuroblastoma, along with exciting therapeutic interventions. This book features a broad collection of contributions from leading investigators in histopathology, molecular mechanisms, genetics, epigenetics, microRNAs, proteomics, and metabolism in controlling growth and death in neuroblastoma. Recent developments in therapeutic interventions for neuroblastoma are also covered extensively, including chapters on surgery, chemotherapy, targeted therapy and immunotherapy. This book is ideal for advanced undergraduate students, graduate students, medical students, postdoctoral fellows, and investigators with an interest in current molecular concepts and therapeutic interventions"--Publisher's description.

Neuroblastoma. --- Neuroblastoma --- Treatment.

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Written by internationally renowned experts, the 3rd edition of this six volume textbook provides detailed practical guidance and advice on the diagnosis and management of the complete range of ocular cancers. Supplying the reader with state-of-the-art knowledge required in order to identify these cancers early and to treat them as effectively as possible, this book is divided into six volumes: Basic Principles, Eyelid and Conjunctival Tumors, Orbital Tumors, Uveal Tumors, Retinal Tumors, and Retinoblastoma. The information presented enables readers to provide effective patient care using the latest knowledge on ophthalmic oncology and to verify diagnostic conclusions based on comparison with numerous full-color clinical photographs from the authors' private collections, histopathologic microphotographs, imaging studies, and crisp illustrations. Clinical Ophthalmic Oncology's clinically focused and user-friendly format allows for rapid retrieval of information in daily practice and is written for residents, fellows, and any physician involved in the care of patients with ocular or orbital malignancies. Additionally, this edition adds several hundred new images to improve comprehension of procedures and techniques. This volume describes the classification, differential diagnosis, and imaging of retinoblastoma and discusses the most suitable treatment options for different tumor types.

Retinoblastoma. --- Glioblastoma, Retinal --- Glioma, Retinal --- Neuroblastoma, Retinal --- Retinal glioblastoma --- Retinal glioma --- Retinal neuroblastoma --- Neuroblastoma --- Pseudoglioma --- Retina --- Cancer --- Ophthalmology. --- Oncology  . --- Oncology. --- Tumors --- Medicine --- Eye --- Diseases

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This book provides a state-of-the-art review of the biology, treatment, and other critical aspects of neuroblastoma, reflecting the dramatic advances that have been achieved in understanding and management. Topics are arranged according to the book’s dominant themes of the “seed” (tumor genomics, epigenetics, metabolism, and stem cells) and the “soil” (tumor microenvironment, adaptive and innate immunity, and exosomes) and how both of these influences can serve as rich targets for intervention, whether by targeted molecular therapy or immunotherapy. Therapeutic strategies that are currently in use or under consideration for the future are discussed in detail, with the focus on precision medicine. Further individual chapters are devoted to the biology and genetics of relapsed/refractory neuroblastoma and emerging methods of evaluating tumor burden. Finally, in keeping with the, albeit modest, increase in cure rates in high-risk disease, immune and cellular therapies are reviewed. This coverage of what is becoming a not-so-enigmatic tumor will appeal to a broad readership including both experimental oncologists and clinicians who care for patients with neuroblastoma.

Oncology. --- Pediatrics. --- Neurology. --- Neuroblastoma. --- Precision Medicine. --- Tumor Microenvironment.

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Tumors of neuroblastoma group are heterogenous and their molecular/genomic properties are closely related to the prognosis of patients: some children enjoy an excellent clinical course after biopsy/surgery alone, and others suffer from a fatal outcome even after an intensive treatment. Recent progress has also started disclosing critical significance of cross-talking between neuroblastoma cells and their microenvironment in predicting clinical behaviors of individual cases. In this book, the world distinguished investigators report clinical and biological characteristics of this disease.

Neuroblastoma. --- Hutchinson's syndrome --- Pepper's syndrome --- Sympathicoblastoma --- Cancer in children --- Nervous system --- Sarcoma --- Cancer --- Oncology

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This comprehensive resource on the current understanding of retinoblastoma addresses all of the essential aspects of retinoblastoma and its management, including: its molecular biology and genetics, management by intraarterial and intravitreal chemotherapy, electroretinogram monitoring of treatment, pharmacokinetic studies, high-risk features, treatment of metastatic disease, and long-term follow-up. The book represents a collaborative project involving ophthalmic oncologists, geneticists, pediatric oncologists, interventional neuroradiologists, electrophysiologists, and basic scientists who are at the forefront of their field. It is written in an accessible manner, and a wealth of tables, figures, and exemplary images are included to enhance the understanding of concepts.

Medicine & Public Health. --- Ophthalmology. --- Oncology. --- Pediatrics. --- Medicine. --- Médecine --- Cancérologie --- Ophtalmologie --- Pédiatrie --- Eye -- Tumors. --- Retinoblastoma. --- Medicine --- Health & Biological Sciences --- Ophthalmology & Optometry --- Eye --- Tumors. --- Glioblastoma, Retinal --- Glioma, Retinal --- Neuroblastoma, Retinal --- Retinal glioblastoma --- Retinal glioma --- Retinal neuroblastoma --- Neuroblastoma --- Pseudoglioma --- Retina --- Cancer --- Oncology  . --- Paediatrics --- Pediatric medicine --- Children --- Tumors --- Diseases --- Health and hygiene