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Animal and Translational Models for CNS Drug Discovery combines the experience of academic, clinical and pharmaceutical neuroscientists in a unique collaborative approach to provide a greater understanding of the relevance of animal models of neuropsychiatric disorders and their role as translational tools for the discovery of CNS drugs being developed for the treatment of these disorders. The focus of this three-volume series of essays is to present a consensual picture of the translational value of animal models from leading experts actively involved in the use of animal models for

Animal models in research. --- Central Nervous System -- drug therapy. --- Disease Models, Animal. --- Drug Discovery. --- Mental Disorders -- drug therapy. --- Neuropharmacology -- methods. --- Neuropharmacology -- Research. --- Pharmacy, Therapeutics, & Pharmacology --- Health & Biological Sciences --- Neuropharmacology --- Research.

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Extensively updated since its second edition in 1985, Chemotherapy in Psychiatry, Third Edition, again addresses basic aspects of modern psychopharmacology and clinical applications of drugs used in the treatment of major psychiatric disorders, with major emphasis on psychotic, bipolar, and depressive disorders. The presentation covers descriptions of the main classes of psychotropic drugs, selected information concerning their known action mechanisms and metabolic disposition, and their clinical applications for acute illnesses and to prevent recurrences and long-term morbidity. Also covered are limitations and adverse effects of each type of agent, with emphasis on the fact that all psychotropic medicines have adverse effects that range from annoying to potentially lethal. Chemotherapy in Psychiatry, Third Edition, outlines the need to balance benefits and risks at the level of individual persons. Authoritative, and an important contribution to the literature, Chemotherapy in Psychiatry, Third Edition is an invaluable resource for physicians, scientists, trainees, and policymakers.

Mental disorders -- Drug therapy. --- Mental illness -- Chemotherapy. --- Psychopharmacology. --- Psychotropic drugs. --- Mental illness --- Psychotropic drugs --- Psychopharmacology --- Central Nervous System Agents --- Behavioral Sciences --- Pharmacology --- Psychiatry and Psychology --- Psychiatric Somatic Therapies --- Therapeutics --- Biological Science Disciplines --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Therapeutic Uses --- Behavioral Disciplines and Activities --- Health Occupations --- Pharmacologic Actions --- Disciplines and Occupations --- Natural Science Disciplines --- Chemical Actions and Uses --- Chemicals and Drugs --- Mental Disorders --- Drug Therapy --- Psychotropic Drugs --- Medicine --- Psychiatry --- Health & Biological Sciences --- Neurology --- Psychopharmacotherapy --- Chemotherapy --- Chemotherapy. --- Medicine. --- Neurosciences. --- Internal medicine. --- Neurology. --- Psychiatry. --- Medicine & Public Health. --- Internal Medicine. --- Neural sciences --- Neurological sciences --- Neuroscience --- Medical sciences --- Nervous system --- Medicine, Internal --- Medicine and psychology --- Mental health --- Psychology, Pathological --- Neuropsychiatry --- Diseases --- Neurology .

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Continuous rigorous research in basic neurosciences and in clinical studies has enormously increased our knowledge of the neurobiological basis of mental functions and of the neuronal dysfunctions underlying such diseases as schizophrenia, depression, attention deficit disorder, and Parkinson's disease. A transmitter system does not work in isolation, it interacts with other transmitters and the balance between several transmitter determines the outcome, either physiological or pathological. Such a critical balance exists between dopamine and glutamate, which in many brain areas play functionally opposing roles. In Dopamine and Glutamate in Psychiatric Disorders, a panel of neurochemists, pharmacologists, experimental psychologists, and clinicians summarizes our current understanding of the interactive role of dopamine and glutamate in psychiatric diseases and from that develops novel therapeutic strategies and possibilities for the future. Among the new ideas presented are hypotheses on the role of dopamine and glutamate in aggression, the glutamate system in anxiety disorders, glutamate and neurodegeneration, on the origin, progression, and cognitive aspects of Parkinson's disease. Additional chapters offer illuminating insights into a variety of psychiatric diseases, including attention deficit hyperactivity disorder, stress, aggression, addiction, schizophrenia, depression, social phobias, dementias, bulimia, and neurodegenerative diseases like Parkinson's and Alzheimer's diseases. Each chapter summarizes the prevalence and symptoms of the disease and explains the involvement of dopamine and/or glutamate systems using the newer molecular approaches such as transgenic knockout or knockin mice and recent brain imaging techniques. The authors also offer a critical selection and evaluation of relevant literature and a description of future directions for new therapy development. Path-breaking and insightful, Dopamine and Glutamate in Psychiatric Disorders offers behavioral pharmacologists, neurobiologists, and clinicians an enlightening review of the neurobiological basis and treatment strategies of today's most important psychiatric and neurological diseases.

Medicine & Public Health. --- Psychiatry. --- Medicine. --- Médecine --- Psychiatrie --- Antidepressive Agents -- pharmacology. --- Antipsychotic Agents -- pharmacology. --- Dopamine -- Pathophysiology. --- Glutamate -- Pathophysiology. --- Mental Disorders -- drug therapy. --- Mental Disorders -- etiology. --- Nervous System Diseases -- drug therapy. --- Nervous System Diseases -- etiology. --- Neuropsychiatry. --- Neurotransmitter receptors. --- Neuropsychiatry --- Dopamine --- Glutamate --- Neurotransmitter receptors --- Tranquilizing Agents --- Receptors, Catecholamine --- Amino Acids, Dicarboxylic --- Psychiatry and Psychology --- Psychotropic Drugs --- Excitatory Amino Acids --- Receptors, Amino Acid --- Diseases --- Amino Acids, Acidic --- Catecholamines --- Central Nervous System Agents --- Amino Acids --- Receptors, Biogenic Amine --- Central Nervous System Depressants --- Biogenic Monoamines --- Receptors, Neurotransmitter --- Receptors, G-Protein-Coupled --- Amines --- Amino Acids, Peptides, and Proteins --- Receptors, Cell Surface --- Biogenic Amines --- Organic Chemicals --- Physiological Effects of Drugs --- Therapeutic Uses --- Pharmacologic Actions --- Membrane Proteins --- Chemicals and Drugs --- Proteins --- Chemical Actions and Uses --- Antidepressive Agents --- Antipsychotic Agents --- Mental Disorders --- Glutamic Acid --- Receptors, Dopamine --- Receptors, Glutamate --- Nervous System Diseases --- Medicine --- Psychiatry --- Health & Biological Sciences --- Neurology --- Psychiatry - General --- Pathophysiology --- Glutamic acid --- Pathophysiology. --- Behavioral neurology --- Medicine and psychology --- Mental health --- Psychology, Pathological --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Excitatory amino acids --- Umami (Taste) --- Biogenic amines --- Bromocriptine --- Neurotransmitters --- Biological psychiatry --- Cell receptors --- Hormone receptors --- Neural receptors