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The HLA FactsBook presents up-to-date and comprehensive information on the HLA genes in a manner that is accessible to both beginner and expert alike. The focus of the book is on the polymorphic HLA genes (HLA-A, B, C, DP, DQ, and DR) that are typed for in clinical HLA laboratories. Each gene has a dedicated section in which individual entries describe the structure, functions, and population distribution of groups of related allotypes. Fourteen introductory chapters provide a beginner's guide to the basic structure, function, and genetics of the HLA genes, as well as to the nomenclatur

HLA histocompatibility antigens --- Histocompatibility antigens. --- Isoantigens --- HL-A histocompatibility antigens --- HLA antigens --- HLA transplantation antigens --- Human leukocyte antigens --- Transplantation antigens, Human --- Histocompatibility antigens --- Major histocompatibility complex

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The Blood Group Antigen Facts Book has been an essential resource in the hematology, transfusion and immunogenetics fields since its first publication in the late 1990's. The third edition of The Blood Group Antigen Facts Book has been completely revised, updated and expanded to cover all 33 blood group systems. It blends scientific background and clinical applications and provides busy researchers and clinicians with at-a-glance information on over 330 blood group antigens, including history and information on terminology, expression, chromosomal assignment, carrier molecular

Blood group antigens. --- Blood group antigens -- Handbooks, manuals, etc. --- Immunohematology. --- Immunohematology -- Handbooks, manuals, etc. --- Blood group antigens --- Immunohematology --- Antigens, Surface --- Isoantigens --- Antigens --- Biological Factors --- Chemicals and Drugs --- Blood Group Antigens --- Human Anatomy & Physiology --- Health & Biological Sciences --- Physiology --- Blood groups --- Immunological aspects --- Hematology --- Immunology --- Erythrocytes

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Ankylosing spondylitis and Klebsiella is a comprehensive and informative text on the cause of Ankylosing spondylitis. Ankylosing spondylitis (AS) is a condition which affects 20 million people worldwide and is likely caused or initiated by a bowel infection from Klebsiella bacteria.   When a patient is infected by Klebsiella bacteria, his or her immune system will make antibodies against all the antigens or molecules found in the microbe. Because some of the bacterial antigens resemble self tissues, the anti-bacterial antibodies will attack not only the bacteria but also the self tissues such as the joints and the cells having the same HLA molecules, which is how the disease AS starts.  This is the concept of molecular similarity or “molecular mimicry” which previously has been found to work in two other autoimmune diseases; rheumatic fever and rheumatoid arthritis.   The first paper on this subject was published in 1976 and since then over 100 papers on rheumatological topics have been published, from Prof Ebringer’s group, at the Division of Life Sciences, King’s College in London, UK.   The relevant information from these papers is extracted and presented in this book format making it accessible to health professionals, research institutions, pharmaceutical companies and universities and the general public.  .

Ankylosing spondylitis. --- Klebsiella. --- Medicine. --- Rheumatology. --- Ankylosing spondylitis --- Klebsiella --- Enterobacteriaceae --- HLA-B Antigens --- Spondylarthropathies --- Ankylosis --- Spondylarthritis --- Histocompatibility Antigens Class I --- Gram-Negative Facultatively Anaerobic Rods --- HLA Antigens --- Joint Diseases --- Gammaproteobacteria --- Arthritis --- Musculoskeletal Diseases --- Histocompatibility Antigens --- Proteobacteria --- Spondylitis --- Gram-Negative Bacteria --- Antigens, Surface --- Bacteria --- Spinal Diseases --- Isoantigens --- Diseases --- Antigens --- Organisms --- Bone Diseases --- Biological Factors --- Chemicals and Drugs --- Spondylitis, Ankylosing --- HLA-B27 Antigen --- Medicine --- Surgery & Anesthesiology --- Health & Biological Sciences --- Surgery - General and By Type --- Musculoskeletal System Diseases --- Bechterew's disease --- Bekhterev's disease --- Marie-Struempell disease --- Marie-Strümpell spondylitis --- Rheumatoid spondylitis --- Spondylarthritis ankylopoietica --- Spondylitis ankylopoietica --- Medicine & Public Health. --- Spondyloarthropathies --- Internal medicine --- Connective tissues --- Joints

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We have entered the era of molecular immunohematology in which DNA is analyzed to predict red blood cell and platelet phenotypes. Indeed, many laboratories and blood banks across the world have already adopted and implemented molecular techniques. Some fear that serology is now becoming outdated, but immunohematology techniques often supplement the work of serologists, and several leading serology laboratories are the very same ones that were early adopters of molecular immunohematology. This book is a thorough review of molecular immunohematology and is aimed at anyone interested in how it is changing blood bank and transfusion medicine. BeadChip Molecular Immunohematology opens with a history of serology before it provides an overview of gene expression, how genetic variations translate into antigenic differences on the surfaces of cells, and techniques that have been developed to detect genetic variations. It then describes in detail the BeadChip technology developed by BioArray Solutions, the molecular immunohematology system that has been most widely adopted in blood blank laboratories. The remainder of the book focuses on analyses and case studies from around the world to describe how molecular immunohematology is being used in various settings for various purposes. It includes a discussion of the significant advances that have been made to incorporate Rh testing on the BeadChip platform as well as the potential use of that system.

Blood banks -- Congresses. --- Blood banks. --- Blood Group Antigens. --- Blood Grouping and Crossmatching. --- Blood Transfusion -- methods. --- Gene Expression Profiling. --- Hematologic Diseases -- immunology. --- Immunohematology. --- Blood --- Immunology --- Medical laboratories --- Medicine --- Monoclonal antibodies --- Nucleic Acid Hybridization --- Molecular Probe Techniques --- Genetic Techniques --- Isoantigens --- Investigative Techniques --- Microarray Analysis --- Sequence Analysis --- Biological Specimen Banks --- Antigens, Surface --- Histocompatibility Testing --- Hematologic Tests --- Immunologic Tests --- Antigens --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Microchip Analytical Procedures --- Laboratory Techniques and Procedures --- Health Facilities --- Blood Grouping and Crossmatching --- Oligonucleotide Array Sequence Analysis --- Methods --- Blood Group Antigens --- Gene Expression Profiling --- Blood Banks --- Biological Factors --- Health Care Facilities, Manpower, and Services --- Immunologic Techniques --- Chemistry Techniques, Analytical --- Diagnosis --- Chemicals and Drugs --- Health Care --- Health & Biological Sciences --- Hematologic Diseases --- Transfusion --- Immunology. --- Medical laboratories. --- Medicine. --- Monoclonal antibodies. --- Antibodies, Monoclonal --- Monoclonal immunoglobulins --- Clinical sciences --- Medical profession --- Immunobiology --- Blood transfusion --- Blood transfusion therapy --- Hemotherapy --- Transfusion medicine --- Transfusion of blood --- Transfusion therapy --- Transfusion therapy, Blood --- Transfusion. --- Antibodies. --- Laboratory medicine. --- Molecular biology. --- Blood transfusion. --- Biomedicine. --- Biomedicine general. --- Laboratory Medicine. --- Molecular Medicine. --- Blood Transfusion Medicine. --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Serology --- Immunoglobulins --- Molecular cloning --- Diagnosis, Laboratory --- Health facilities --- Laboratories --- Surgery --- Blood banks --- Blood groups --- Hospitals --- Transfusion-free surgery --- Transfusion committees --- Biomedicine, general. --- Health Workforce --- Molecular biochemistry --- Molecular biophysics --- Biochemistry --- Biophysics --- Biomolecules --- Systems biology --- Clinical medicine --- Clinical pathology --- Diagnostic laboratory tests --- Laboratory diagnosis --- Laboratory medicine --- Medical laboratory diagnosis --- Antibodies --- Immune globulins --- Immune serum globulin --- Blood proteins --- Globulins --- Plasma cells --- Antibody diversity --- Bacterial immunoglobulin-binding proteins