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Bladder cancer is the second most common genitourinary malignancy, with 81,190 estimated new diagnoses in 2018, in the United States alone. Transurethral resection of the bladder and radical cystectomy with bilateral pelvic lymph node dissection constitute the standard treatment for non-muscle invasive or very high-risk non-muscle invasive bladder cancer, respectively. However, survival expectations have not shown to improve in the last 20 years, and new diagnostic and therapeutic tools are urgently needed to improve the outcomes of this potentially lethal disease.
iron deficiency anemia --- fermented goat milk --- brain molecular functions --- neuroprotective effect --- iron supplementation --- pregnancy --- randomized controlled trial --- serum ferritin --- hemoglobin --- iron status --- iron stores --- HFE gene --- iron --- anemia --- kidney --- hepcidin --- erythropoietin --- celiac disease --- gluten-free diet --- iron deficiency --- micronutrient deficiencies --- infant --- breast milk --- formula milk --- high intensity exercise --- ubiquinol --- hematological parameters --- inflammation --- ergogenic effect --- acai --- erythropoiesis --- anaemia --- altitude adjustment --- haemoglobin --- South Africa --- women of reproductive age --- nutritional adequacy --- children --- fermented cow and goat milk --- iron homeostasis --- iron repletion --- gene and protein expression --- redox unbalance --- prematurity --- transfusion --- blood-sparing
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This book contains selected papers from the 9th annual conference of the Hellenic Society of Biochemistry and Physiology of Exercise (2019). Exercise biochemistry and exercise physiology are two closely related sport sciences that examine how muscle activity alters the way our bodies (and those of other animals) function at the levels of molecules, cells, organs, and whole body. Included in the book is original research on biochemical and physiological adaptations of children, adolescents, and adults to exercise training; on the use of biochemical and physiological tests to assess sport performance; and on how exercise can fight disease.
intermittent swimming --- swimming training --- arm stroke rate --- arm stroke length --- validity --- range of motion --- hamstrings --- stretching exercises --- gymnastics --- team sports --- straight leg raise --- youth --- fascicle length --- muscle thickness --- maturation --- musculotendinous junction --- ultrasound --- breast cancer --- chemotherapy --- physical activity --- quality of life --- exercise --- QoL --- treatment --- preadolescence --- child --- post-activation performance enhancement --- sprint --- warm-up --- rate of perceived exertion --- haemoglobin --- diabetes --- fitness --- cardiovascular health --- nutrition --- aerobic fitness --- intermittent exercise --- prepubertal children --- lactate threshold --- continuous swimming --- physiological responses --- biomechanical parameters --- female --- adolescence --- resistance training --- plyometric training --- strength training --- endurance --- aerobic performance --- running economy --- maximal oxygen consumption --- oxygen fractional utilization --- running
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Newborn Screening for Sickle Cell Disease and other Haemoglobinopathies is a Special Issue of the International Journal of Neonatal Screening. Sickle cell disease is one of the most common inherited blood disorders, with a huge impact on health care systems due to high morbidity and high mortality associated with the undiagnosed disease. Newborn screening helps to make the diagnosis early and to prevent fatal complications and diagnostic odysseys. This book gives an overview of diagnostic standards in newborn screening for sickle cell disease and examples of existing newborn screening programs.
glucose-6-phosphate dehydrogenase --- hydroxyurea/hydroxycarbamide --- n/a --- cord blood --- screening --- hemoglobin pattern --- capillary electrophoresis --- sickle cell disease --- (recommended) screening panel --- vaso-occlusive crisis --- Guthrie spots --- newborn screening) --- foetal haemoglobin --- harmonisation --- review --- birth prevalence --- G6PD deficiency --- prevention --- end-organ damage --- thalassemia --- MALDI-TOF --- IEF --- acute chest syndrome --- India --- sickle cell and thalassaemia screening programme --- ‘Getting to Outcomes’ --- newborn screening --- hemoglobinopathy --- service users --- public health engagement --- automated HPLC --- Kaduna State --- gene therapy for haemoglobinopathies --- ?-globin gene --- methods --- neonatal screening program --- malaria --- Plasmodium vivax --- sub-Saharan Africa --- patient organisations --- health policy --- pathophysiology --- Sickle Cell Disease --- mass spectrometry --- sickle cell disorder --- neonatal screening --- non-tribal --- Nigeria --- point-of-care --- HPLC --- laboratory methods --- registry --- patient advocacy --- bone marrow transplant --- anaemia --- hemoglobinopathies --- tribal --- newborn --- burden of disease --- patient representatives --- diagnostics --- policy making --- haemolysis --- Caribbean --- high performance liquid chromatography (HPLC) --- sickle cell disease (SCD) --- implementation science --- 'Getting to Outcomes'
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Biomarkers of environmental toxicants are measures of exposures, some of which can serve to assess disease risk and inter-individual susceptibilities. Metabolites, protein and DNA adducts also serve to elucidate the mechanisms of the bioactivation and detoxication of reactive toxicant intermediates. Some environmental chemicals act as modulators of gene and protein activity, and induce the dysbiosis of the microbiome, which impacts the metabolome and overall health. In this Special Issue on “Biomarkers of Environmental Toxicants”, review articles and original research studies are featured, covering the latest bioanalytical, biochemical and mass spectrometry-based technologies, to monitor exposures through targeted and non-targeted methods, and mechanistic studies that examine the biological effects of environmental toxicants in cells and humans. Diverse topics, such as exposome, microbiome, DNA/protein adducts and t-RNA modifications, as well as important environment toxicants, including heavy metals, benzene, phthalates, aldehydes, glycidol, tobacco smoke and aristolochic acids, are covered. Novel analytical methods, such as protein adductomics, DNA adduct analysis in formalin-fixed paraffin-embedded tissues, site-specific mutagenesis assay and accelerator mass spectrometry, are also included. This collection provides a valuable update of the most recent biochemical and analytical tools that employ biomarkers in toxicology research, biomarker discovery, and exposure and risk assessment in population-based studies.
manganese --- lead --- cadmium --- arsenic --- hair --- children --- environment --- carcinogen --- DNA adducts --- biomonitoring --- formalin-fixed paraffin-embedded tissues --- biomarker --- mass spectrometry --- human biomonitoring --- urine --- non-occupational exposure --- S-phenyl-mercapturic acid --- HPLC-MS/MS --- glycidol --- Hb adduct --- N-(2.3-dihydroxypropyl)valine --- in vivo --- cancer risk --- UPLC/MS/MS --- aristolochic acids --- food contamination --- environmental pollution --- root uptake --- aristolochic acid nephropathy --- Balkan endemic nephropathy --- chronic kidney disease --- tobacco smoke --- human carcinogen --- biomarkers --- epitranscriptomics --- tRNA modifications --- stress response mechanisms --- codon-biased translation --- phthalate --- DEHP --- human exposure --- toxicity --- reproductive --- accelerator mass spectrometry --- cavity ring down spectrophotometry --- radiocarbon --- naphthalene --- benzo[a]pyrene --- cell turnover --- triclocarban --- metastasis --- haemoglobin --- albumin --- protein adducts --- aldehydes --- genotoxicity --- cancer --- diseases --- oxidative stress --- exposure biomarkers --- high-resolution mass spectrometry --- data-dependent profiling --- derivatization --- biological fluids --- isotope labeling --- DNA lesion --- DNA damage --- shuttle vector technique --- replication block --- mutagenicity --- mutational spectrum --- mutational signature --- DNA repair --- DNA adduct bypass --- site-specific mutagenesis --- chemical exposome --- environmental monitoring --- disease --- bioinformatics --- gut microbiome --- chemical toxicity --- n/a
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The prevalence of diabetes is on the increase in the UK and worldwide, partly due to changes in lifestyle which predispose individuals to overweight and obesity. It is estimated that about 90% of the currently diagnosed adults have type 2 diabetes, and based on the World Health Organisation (WHO) report, about 422 million adults were living with diabetes in 2014 compared with 108 million in 1980; this condition caused about 1.5 million deaths in 2012. In the United States of America, it is estimated that about 30.3 million adults are living with diabetes, with a further 1.5 million new diabetes cases diagnosed every year, representing an increasing prevalence of this condition. Diabetes represents a major public health challenge, despite advances in technology and the pharmaceutical industry. These problems may be in the form of acute or long-term complications. Therefore, in order to attenuate the problems of diabetes, management strategies usually include lifestyle changes such as increased physical activity and dietary interventions. Studies which evaluate the role of nutrition in the management of type 2 diabetes often involve human and animal models as these approaches enable us to have a broader and more in-depth understanding of the condition. In some cases, diabetes may co-exist with other conditions, such as stroke, and these may present unique challenges with regard to nutritional interventions. This Special Issue aims to evaluate the risk factors associated with type 2 diabetes and the role of the diet in the management of people with this condition. This evidence is drawn from both human and animal studies.
low-carbohydrate --- lipids --- carbohydrate restricted diet --- aldosterone --- high fat diet --- interleukin-6 --- rosemary extract --- Hedychium coronarium --- isomaltulose --- low carbohydrate diet --- folk medicine --- free fatty acids (FFA) --- high-density lipoprotein cholesterol --- mushroom --- protein and fat counting --- incretins --- fish oil --- almond --- Japanese --- vitamin D deficiency --- low energy diet --- AMPK --- women --- glycaemic index --- T2DM --- zinc status --- ginseng --- longitudinal analysis --- dietary management approaches --- glucose monitoring --- gut microbiome --- nutritional supplement --- carbohydrate counting --- gestational diabetes --- type 2 diabetes mellitus --- very-low-calorie --- inflammatory parameters --- vitamin D --- subjective appetite --- randomised controlled trial --- total body lean --- insulin secretion --- systematic review --- lactic acid bacteria --- food --- type 2 diabetes --- fish --- zinc intake --- glycaemic control --- diabetes --- dairy products --- glycated haemoglobin --- short chain fatty acids --- glycated hemoglobin A --- glycemic control --- vegetable oil --- standard formula --- cardiovascular risk factors --- DASH --- insulin dosage --- appendicular fat --- body composition --- total body fat --- micronutrients --- 25-OH-D --- obesity --- diabetes reversal --- enteral nutrition --- PUFA --- body mass index --- metabolic syndrome --- lifestyle management --- nutrition --- streptozotocin --- nuts --- enteral tube feeding --- lipid profile --- macronutrients --- triglyceride --- tempeh --- cohort study --- diabetes specific formula --- polyunsaturated fatty acids --- diabetes mellitus --- calcium intake --- hyperglycemia --- epidemiology --- trace elements --- dietary intake --- muscle --- appendicular lean --- peanut --- insulin resistance --- sucromalt --- pancreatectomy --- energy restricted diet --- glycemic index --- type 1 diabetes --- fasting blood glucose --- bariatric surgery --- prediabetes --- aronia --- meta-analysis --- chronic conditions --- diabetes management --- dietary pattern --- diet quality --- lipid parameters --- feces
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In this book, the emphasis is on various training interventions. Types of exercises that can help improve performance in athletes and health in people facing poor movement diseases.Also, we have presented a variety of strength training interventions in the form of various types of research. On the other hand, we continue to monitor internal and external loads related to non-contact injuries and performance analysis.
Humanities --- Social interaction --- COVID-19 --- immune response --- chronic diseases --- exercise --- oxidative stress --- anti-inflammatory treatment --- fibroblast growth factor 21 --- cytokines --- myokines --- anabolic–androgenic steroids --- athletes --- baroreflex sensitivity --- cardiac autonomic nervous system --- cardiac function --- physical guidance --- tracking task --- cerebral palsy --- challenge point framework --- frequency --- virtual driving --- physical activity --- behavioral status --- mental state --- older men --- reaction time --- visual coordination --- visual reaction --- female --- football --- autonomic modulation --- fatigue --- training load --- altitude --- haemoglobin --- erythropoietin --- hypoxia --- endurance --- sand --- occupational health --- tactical athlete --- landing error scoring system --- reactive strength index --- tactical personnel --- force plates --- military --- law enforcement --- neuromuscular fatigue --- spinal curvature --- Paralympic volleyball --- compensation strategy --- thoracic hyperkyphosis --- adapted training --- low back pain --- kidney failure --- AKI --- health --- biomarkers --- strenuous exercise --- mountain running --- kidney function --- off-road running --- performance --- kinematics --- laser --- computer vision --- inertial device --- IMU --- injury risk --- high load --- external monitoring --- high-speed distance --- global positioning system --- movement analysis --- handball shot --- internal load --- shot precision --- motor decisions-making --- GPS --- T-Patterns --- acceleration --- motor praxeology --- role --- anatomy --- spine --- thoracic spine --- low back --- lumbar spine --- biomechanics --- rowing --- antioxidant status --- nutrition --- reactive oxygen species (ROS) --- biomechanical analysis --- pressure insoles --- Xsens motion capture system --- performance analysis --- recreational skiers --- dry-land training --- GEE modeling --- oxygen consumption --- strength training --- surface electromyography --- bone mineral --- skeletomuscular robusticity --- elite athletes --- DEXA --- executive functions --- shooting performance --- gender differences --- cadets --- resistance training --- power exercise --- team sport --- conditioning capabilities --- lower extremity --- dynamic balance --- dose–response --- training intensity --- elastic bands --- chain --- eccentric training --- decline squat --- patellar tendon --- sonoelastography --- stiffness
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