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This book is an essential handbook on bisphosphonates, the most widely used new class of drugs for osteoporosis therapy. It reviews basic physiology in addition to the indications and adverse reactions of these drugs. Bisphosphonates in Bone Disease, 4E, discusses the compounds' chemistry, mechanisms of action, and animal toxicology before presenting a clinical picture of the diseases treated by bisphosphonates. The book provides a table listing the trade names of the commercially available bisphosphonates, registered indications, and the available forms for various countries. The revis

Diphosphonates --- Bones --- Therapeutic use. --- Diseases --- Chemotherapy.

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Osteoporosis is a global threat because it can impact every human being as they age. In this new edition, the authors point out the enormous scale of the problem in terms of human suffering, morbidity and mortality on the one hand, and the astronomical national costs on the other. Written in an easy-to-read style, this book updates physicians on the current knowledge about bone structure, physiology and pathology, with an emphasis on the diagnosis, therapy and prevention of osteoporosis. Its purpose is to educate members of the medical profession about this widespread and potentially disabling disease, while providing information on related current evidence-based medicine. The book covers everything from basic physiology to osteoporosis diagnosis, including utility of specialized tests and current treatment recommendations, and will provide the primary care physician with sound medical knowledge in the prevention and management of osteoporosis. It is up-beat and optimistic, with a touch of humor; it is scientifically based but provides easy-to-follow guidelines for lifelong maintenance of skeletal structure and function. Osteoporosis is preventable if doctors want it to be, and every doctor can contribute. Bone is every doctor's and every body's business.

Bone Density. --- Diphosphonates -- therapeutic use. --- Hormone Replacement Therapy. --- Osteoporosis -- Diagnosis. --- Osteoporosis -- prevention & control. --- Osteoporosis -- Prevention. --- Osteoporosis -- Treatment. --- Osteoporosis. --- Risk Factors. --- Osteoporosis --- Bone Density --- Risk Factors --- Diphosphonates --- Hormone Replacement Therapy --- Risk --- Causality --- Drug Therapy --- Organophosphorus Compounds --- Musculoskeletal Physiological Phenomena --- Bone Diseases, Metabolic --- Probability --- Epidemiologic Factors --- Therapeutics --- Bone Diseases --- Musculoskeletal and Neural Physiological Phenomena --- Organic Chemicals --- Statistics as Topic --- Quality of Health Care --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Public Health --- Phenomena and Processes --- Musculoskeletal Diseases --- Chemicals and Drugs --- Health Care Evaluation Mechanisms --- Environment and Public Health --- Diseases --- Health Care Quality, Access, and Evaluation --- Epidemiologic Methods --- Health Care --- Investigative Techniques --- Musculoskeletal System Diseases --- Medical Professional Practice --- Medicine --- Health & Biological Sciences --- Prevention --- Diagnosis --- Treatment --- Prevention. --- Diagnosis. --- Treatment. --- Medicine. --- General practice (Medicine). --- Gynecology. --- Internal medicine. --- Endocrinology. --- Orthopedics. --- Medicine & Public Health. --- General Practice / Family Medicine. --- Internal Medicine. --- Bones --- Vitamin D deficiency --- Family medicine. --- Orthopaedics --- Orthopedia --- Surgery --- Internal medicine --- Hormones --- Gynaecology --- Generative organs, Female --- Medicine, Internal --- Family practice (Medicine) --- General practice (Medicine) --- Physicians (General practice) --- Gynecology . --- Endocrinology .

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Bone metastases continue to be a major cause of morbidity in cancer patients, but improved understanding of the biology of bone metastases has led to the identification of drugs that are of potential value in not only their treatment but also their prevention. This book, written by recognized experts in the field, provides a detailed overview of current knowledge on this subject. One important focus of the book is the efficacy of bisphosphonates in preventing bone metastases in patients with breast, lung, and prostate cancer and disease progression in cases of multiple myeloma.  The combined use of bisphosphonates and cytostatics is also discussed, with a report on first clinical data.  Further topics addressed include the significance of the bone microenvironment, special issues in the elderly patient, the use of bone turnover markers, and initial findings obtained with denosumab.

Bone Neoplasms -- diagnosis. --- Bone Neoplasms. --- Bones -- Cancer. --- Cancer -- Imaging. --- Bones --- Neoplasms by Site --- Biological Factors --- Organophosphorus Compounds --- Bone Diseases --- Noxae --- Musculoskeletal Diseases --- Chemicals and Drugs --- Neoplasms --- Organic Chemicals --- Toxic Actions --- Diseases --- Chemical Actions and Uses --- Bone Neoplasms --- Cytostatic Agents --- Biological Markers --- Diphosphonates --- Medicine --- Health & Biological Sciences --- Oncology --- Cancer --- Bone metastasis --- Prevention. --- Metastatic bone cancer --- Metastatic bone disease --- Osseous metastasis --- Skeletal metastasis --- Medicine. --- Oncology. --- Surgical oncology. --- Medicine & Public Health. --- Surgical Oncology. --- Oncologic surgery --- Oncological surgery --- Surgical oncology --- Tumors --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Excision --- Treatment --- Metastasis --- Oncology  . --- Cancer Therapy. --- Treatment. --- Cancer therapy --- Cancer treatment --- Therapy