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This Special Issue, consisting of 14 papers, presents the latest findings concerning both numerical and experimental investigations. Their aim is to achieve a reduction in pollutant emissions, as well as an improvement in fuel economy and performance, for internal combustion engines. This will provide readers with a comprehensive, unbiased, and scientifically sound overview of the most recent research and technological developments in this field. More specific topics include: 3D CFD detailed analysis of the fuel injection, combustion and exhaust aftertreatments processes, 1D and 0D, semi-empirical, neural network-based control-oriented models, experimental analysis and the optimization of both conventional and innovative combustion processes.

homogeneous charge compression ignition (HCCI) --- exhaust gas recirculation (EGR) --- dual-fuel --- dimethyl ether (DME) --- exhaust emission --- co-combustion --- dual fuel --- combustion stability --- coefficient of variation of IMEP --- probability density of IMEP --- 0D model --- predictive model --- tumble --- turbulent intensity --- spark-ignition engine --- engine geometry --- AdBlue® injection --- large eddy simulation --- Eulerian–Lagrangian approach --- thermal decomposition --- wall–film formation --- conversion efficiency --- hybrid electric vehicle --- real driving emissions --- fuel consumption --- vehicle performance --- electric supercharger --- Lambda-1 engine --- 48 V Mild Hybrid --- electrically assisted turbocharger --- variable geometry turbocharger-exhaust gas recirculation --- oxygen concentration --- active disturbance rejection control --- model-based --- control --- diesel engine --- ANN --- physics-based model --- semi-empirical model --- CNG --- diesel fuel --- dual fuel engine --- rate of heat release --- ignition delay --- burn duration --- exhaust gas emission --- camless --- electromagnetic variable valve train --- magnetorheological buffer --- soft landing --- solenoid injectors --- indirect-acting piezoelectric injectors --- direct-acting piezoelectric injectors --- engine-out emissions --- combustion noise --- diesel engines --- pollutant emission reduction --- mixing process --- advanced injection strategy --- varying injection rate --- engine torque estimation --- GDI engines --- extended state observer --- online performance --- torque --- nitrogen oxide emissions --- model-based control --- engines --- numerical simulation --- pollutant emissions prediction --- computational fluid dynamics