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Combinational Therapy in Triple Negative Breast Cancer discusses TNBC at the molecular level from a holistic approach, focusing on combinational strategies targeting various pathways involved in this specific cancer type. Using a monotherapy for the treatment of cancer, especially high-grade tumors like TNBC, is mostly worthless due to the inherent genetic instability of tumor cells to develop intrinsic and acquired resistance. Combination therapy presents more, or at least the same, effectiveness with lower doses of every single agent and decreases the likelihood of chemoresistance, making it essential to understand for multiple therapy options.

Breast --- Cancer --- Treatment. --- Triple Negative Breast Neoplasms --- Drug Therapy, Combination --- therapy

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"Combination Drug Delivery Approach as an Effective Therapy for Various Diseases explores the use of bioengineering tools in combination drug delivery approaches to control various diseases at different clinical stages of synergistic action, varying mechanisms of action, and during the suppression of drug resistance. The book presents fundamental knowledge on the experiential and experimental aspects of drug combination approaches in order to equip rational applications in preventing the emergence of resistance during the treatment of various diseases. It provides a holistic understanding of the principles behind formation, characterization, applications, regulations, toxicity, challenges and future perspectives of combination drug delivery approaches."--

Drug delivery systems. --- Delivery systems, Drug --- Drug administration technology --- Drug delivery technology --- Drugs --- Pharmaceutical technology --- Delivery systems --- Chemotherapy. --- Chemotherapy, Combination. --- Drug resistance --- Drug Delivery Systems --- Drug Therapy, Combination --- Drug Synergism --- Drug Resistance --- Prevention.

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Early clinical trials of the new molecular-based anticancer agents have shown that many are marginal in controlling cancer, but prove to be potent modulators and potentiators of chemotherapy-induced apoptosis when used in combination with classic cytotoxic drugs or radiation. In Combination Cancer Therapy: Modulators and Potentiators, expert physician-scientists and clinicians with first-hand experience in the clinical development of targeted therapies review those combinations that hold the most promise for the future of medical oncology, detailing their optimal sequence, pharmacokinetic interactions, and interaction with downstream cellular signals. The combinations run the gamut of targeted therapies against cell surface receptors (EGF-R and HER2), the cell cycle (the CDKs), signal transduction events (PKC and NF-kB), apoptosis (bcl-2), as well as focused therapies in ovarian cancer, hematologic diseases, and breast cancer. The authors emphasize novel translational approaches that are rapidly moving from the laboratory benchtop to the patient's bedside as a new generation of cancer therapeutics. Cutting-edge and forward-looking, Combination Cancer Therapy: Modulators and Potentiators offers everyone in the fields of cancer drug development and therapy a powerful new understanding of the optimal sequencing and scheduling of new combination drug therapies necessary to maximize the effects for cancer patients today.

Neoplasms --- Drug Therapy, Combination. --- Cancer --- Apoptosis. --- Apoptose --- drug therapy. --- Chemotherapy. --- Treatment. --- Chimiothérapie --- Traitement --- Apoptosis --- Drug Therapy, Combination --- Chemotherapy --- Treatment --- drug therapy --- Cancer -- Chemotherapy. --- Cancer -- Treatment. --- Drug Therapy --- Therapeutics --- Diseases --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Oncology --- Medicine --- Health & Biological Sciences --- Cancer therapy --- Cancer treatment --- Therapy --- Medicine. --- Oncology. --- Medicine & Public Health. --- Tumors --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Cell death --- Antineoplastic agents --- Oncology  . --- Cancer - Chemotherapy --- Cancer - Treatment --- Neoplasms - drug therapy

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Liver disease has been identified as a leading cause of death in HIV-infected patients since the introduction of highly active antiretroviral therapy (HAART) in 1996. The HIV treatment community has been caught largely unaware of this emerging dilemma. Many HIV care providers are ill-equipped to understand and interpret liver injury patterns, or to provide comprehensive care and management for viral coinfections which they are not familiar with. HIV and Liver Disease provides a comprehensive update of the field covering the epidemiology, pathogenesis, management and treatment of liver disease in patients with HIV infection. The volume will help HIV care providers understand and interpret liver injury patterns, and/or provide comprehensive care and management for viral coinfections. Gastroenterologists and hepatologists will gain an understanding of complex drug regimens that are used to treat HIV and which may impact HCV and HBV treatment. Written by expert clinicians and researchers across multiple disciplines, HIV and Liver Disease will be of great value to gastroenterologists, hepatologists, infectious disease practitioners, as well as other health care providers who provide care or participate in research in the field of HIV.

HIV infections -- Complications. --- HIV infections. --- Liver -- Diseases. --- Liver --- HIV infections --- Virus Diseases --- Sexually Transmitted Diseases, Viral --- Drug Therapy, Combination --- Digestive System Diseases --- Hepatitis --- Immunologic Deficiency Syndromes --- Lentivirus Infections --- Drug Therapy --- Diseases --- Retroviridae Infections --- Immune System Diseases --- Sexually Transmitted Diseases --- Therapeutics --- RNA Virus Infections --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Hepatitis, Viral, Human --- HIV Infections --- Liver Diseases --- Antiretroviral Therapy, Highly Active --- Medicine --- Health & Biological Sciences --- Gastroenterology --- Complications --- Diseases. --- HIV (Viruses) infections --- HTLV-III infections --- HTLV-III-LAV infections --- Human T-lymphotropic virus III infections --- Medicine. --- Internal medicine. --- Gastroenterology. --- Hepatology. --- Medicine & Public Health. --- Internal Medicine. --- Lentivirus infections --- Sexually transmitted diseases --- Clinical medicine. --- Medicine, Internal --- Medicine, Clinical --- Internal medicine --- Digestive organs --- Gastroenterology .

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Induction chemotherapy, as part of an integrated plan of management for locally advanced cancers, is being practised throughout the world in independent, isolated departments in universities, teaching hospitals, and clinical schools. Frequently, however, teams are relatively unaware of the work being undertaken in other institutions, and this situation may slow further progress. This book aims to present the full range of management techniques and practices used in induction chemotherapy within one accessible volume. It provides up-to-date information on the pioneering and cutting edge practices employed in different institutions and documents the advantages of integrated treatment schedules. Patient selection is discussed, and each of the cancer types for which induction therapy has proved important is considered in detail. All who are responsible for the treatment of patients with locally advanced cancers will find this book to be an invaluable source of information. It will be particularly interesting for specialist oncologists aiming to set up and develop fully comprehensive cancer centres and for health administrators wishing to learn about the benefits of establishing such centres in strategic locations.

Cancer -- Chemotherapy. --- Cancer -- Treatment. --- Chemotherapy. --- Infusions, Parenteral --- Therapeutic Uses --- Diseases --- Therapeutics --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Drug Administration Routes --- Pharmacologic Actions --- Drug Therapy --- Chemical Actions and Uses --- Chemicals and Drugs --- Infusions, Intra-Arterial --- Remission Induction --- Neoplasms --- Antineoplastic Agents --- Medicine --- Health & Biological Sciences --- Oncology --- Chemotherapy, Combination. --- Cancer --- Drug therapy --- Pharmacotherapy --- Combination chemotherapy --- Combination drug therapy --- Drug therapy, Combination --- Polychemotherapy --- Medicine. --- General practice (Medicine). --- Oncology. --- Medicine & Public Health. --- General Practice / Family Medicine. --- Antineoplastic agents --- Drugs --- Pharmacology --- Treatment --- Oncology  . --- Family medicine. --- Family practice (Medicine) --- General practice (Medicine) --- Physicians (General practice) --- Tumors