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This Special Issue contributes original research and review articles on the role of new protein, molecular, and genetic markers used for the diagnosis and progression of civilization diseases, as well as biomarkers useful in the monitoring the effects of the implemented treatment.

pharmacogenomics --- NGS variants --- personalized medicine --- FSHR --- personalized drug therapy --- hedgehog-interacting protein --- impaired fasting glucose --- impaired glucose tolerance --- newly diagnosed diabetes --- normal glucose tolerance --- inflammatory bowel disease --- ulcerative colitis --- Crohn’s disease --- extracellular matrix components --- hyaluronan --- inflammatory bowel diseases (IBD) --- Crohn’s disease (CD) --- ulcerative colitis (UC) --- sulfated glycosaminoglycans (sGAG) --- hyaluronan (HA) --- soluble part of syndecan-1 (sCD138) --- microRNA --- cardiovascular disease --- diabetes --- mortality --- antiplatelet therapy --- platelet reactivity --- Let-7e --- miR-126 --- miR-223 --- miR-125a-3p --- CCL11 --- CCL24 --- CCL26 --- CCR3 --- CRC --- adiponectin --- adipokines --- rheumatology --- obesity --- overweight --- case control study --- rheumatoid arthritis --- TNF-α inhibitors --- bone turnover markers --- PINP --- PICP --- NTX-I --- CTX-I --- RANKL/OPG --- ovarian cancer --- interleukin 21 --- interleukin 22 --- lymphocytes --- macrophages --- dendritic cells --- innate lymphoid cells --- breast cancer --- extracellular matrix --- proteins --- tumorigenesis --- tumor microenvironment

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In this Special Issue, we have published papers on the health-promoting effects of nutraceuticals from different sources, and their effects in different pathologies. Extracts from plants have been analyzed, for example, extracts from olive leaves, Mikania micrantha, the devil’s claw, raspberries and others, alongside marine phytoplankton, egg-yolk and marketed dietary supplements. The effects of these extracts and dietary supplements have been studied in diseases associated with obesity, and in diseases where inflammation pathways are involved. The effectiveness of resveratrol and curcumin to support the anticancer activity of cisplatin has also been reported, as well as the ability of devil’s claw root extract to stimulate the CB2 receptors in synoviocytes in osteoarthritis patients. The anti-oxidant effect of marine phytoplankton has been studied on muscle damage, both in humans and in an animal model, and the effects of the metabolite of antocianin were analyzed in a mouse model of amyotrophic lateral sclerosis. Finally, reviews on the use of lactoferrin, ω3 and ω6 and abscisic acid have been reported, in addition to the crosstalk between prostate cancer and microbiota inflammation. Although it is not yet possible to draw definitive conclusions on the use of nutraceuticals, several mechanisms of action for many of them have been further clarified.

fertility --- ingredients --- male reproduction --- semen parameters --- supplements --- allithiamine --- garlic --- hyperglycaemia --- advanced glycation end-products --- cytokines --- abscisic acid --- prediabetes --- type 2 diabetes mellitus --- metabolic syndrome --- insulin resistance --- adipocyte browning --- AMP-activated protein kinase --- food supplement --- frambinone --- meal frequency --- open-field test --- elevated plus maze --- sensory motor gating --- pre-pulse inhibition --- c-Fos --- amyotrophic lateral sclerosis --- anti-inflammatory --- antioxidant --- phenolic acid --- neuroprotective --- neurodegeneration --- obesity --- overweight --- beta-glucans --- chitosan --- follow up study --- weight loss programs --- weight gain --- weight loss --- body weight changes --- phytoplankton --- antioxidants --- muscle damage --- muscle recovery --- muscle soreness --- Viburnum opulus --- phenolic compounds --- adipogenesis --- PPARγ --- lipase inhibition --- green tea --- epigallocatechin --- lipid profile --- high-fat diet --- fast food --- osteoarthritis --- nutraceuticals --- polyphenols --- volatile compounds --- β-caryophyllene --- eugenol --- FAAH --- cannabinoid receptors --- phospholipases --- lactoferrin --- bovine milk --- nutraceutical --- human health --- resveratrol --- curcumin --- cisplatin --- head and neck cancer --- cell cycle --- apoptosis --- prostate cancer --- microbiota --- nutraceutical compounds --- fecundation --- inflammation --- cytokine --- growth factors --- metabolomics --- lipidomics --- ω-3PUFAs --- ω-6PUFAs --- endocannabinoids --- CRC --- fatty acids --- Gymnema inodorum --- gymnemic acid --- Mikania micrantha --- anti-hypercholesterolemia --- steatosis --- olive leaf --- macrophages

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The book contains four studies that compare experiences from countries with similar legal traditions and examine how the Convention on the Rights of the Child has been integrated and harmonized with national legislation in specific countries. The book demonstrates how the CRC can be implemented in different country contexts in an effort to achieve children's rights uniformly across widely divergent legal traditions. It highlights key developments, identifies trends, and draws general conclusions that provide insight into the legal traditions at issue for advocacy in relationship to the implementation of the CRC, as well as to encourage practical actions. The book proposes a framework for enhancing compatibility of national legislation with human rights instruments and with the CRC in particular. The book endeavors to emphasize the CRC's ideology of indivisibility of rights, solidarity, and partnership in realizing children's rights. The book is a powerful advocacy tool for supporting the implementation of the CRC and Convention on the Elimination of all Forms of Discrimination Against Women (CEDAW).

Children --- 180.1 Kinderrechten - internationaal --- Children (International law) --- International law --- Child welfare --- Legal status, laws, etc. --- Law and legislation --- Law --- Convention on the Rights of the Child --- Adong Kwŏlli Hyŏbyak --- CIDE --- CDN --- Convenção sobre os Direitos da Criança --- Convención de los derechos de los niños --- Convención sobre los Derechos del Niño --- Convention des Nations Unies sur les droits de l'enfant --- Convention internationale des droits de l'enfant --- Convention Internationale relative aux droits de l'enfant --- Convention internationale sur les droits de l'enfant --- Convention of the Rights of the Child --- Convention on Rights of the Child --- Convention relative aux droits de l'enfant --- Convenzione internazionale dei diritti del fanciullo --- Convenzione internazionale sui diritti dell'infanzia e dell'adolescenza --- Convenzione sui diritti del fanciullo --- Convenzione sui diritti dell'infanzia e dell'adolescenza --- CRC --- FN's konvention om barnets rettigheder --- Internationaal Verdrag inzake de Rechten van het Kind --- Ittifāqīyat al-Umam al-Muttaḥidah li-Ḥuqūq al-Ṭifl --- IVRK --- Jidō no kenri jōyaku --- Jidō no kenri ni kansusu jōyaku --- Kodomo no kenri jōyaku --- Kodomo no kenri ni kansuru jōyaku --- Konvensi Hak Anak --- Konvensi Hak-Hak Anak --- Konvensjon om barnets rettigheter --- Konvention om barnets rettigheder --- Konventionen om barnets rättigheter --- Konvent︠s︡ii︠a︡ o pravakh rebenka --- Konwencja o prawach dziecka --- Kunvānsiyūn-i Ḥuqūq-i Kūdak --- Lapsen oikeuksien yleissopimus --- Samningur Sameinuðu þjóðanna um réttindi barnsins --- Simiso Semalungelo Ebantfwana --- Übereinkommen über die Rechte des Kindes --- UN Convention on the Rights of the Child --- United Nations Convention on the Rights of the Child --- Convención de los derechos del niño --- Convenția internațională cu privire la drepturile copilului --- Convenția cu privire la drepturile copilului --- Legal status, laws, etc --- Comparative law --- Human rights --- Children (International law). --- General and Others --- Children - Legal status, laws, etc

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This book explores the meaning and implementation of international children’s rights law, as laid down in the United Nations Convention on the Rights of the Child and related international and regional human rights instruments. It considers the application of international children’s rights at the national level and addresses key procedural and institutional matters concerning children’s rights implementation, including monitoring, complaints mechanisms, effective remedies, advocacy and international agenda-setting. The book breaks new ground by analysing a wide range of international children’s rights issues from a legal perspective. It incorporates a comparative perspective on children’s rights law at the international, regional and domestic level and contains information on evidence-based strategies towards the implementation and enforcement of international children’s rights law. The book is targeted at academics, legal and other professionals, and advanced students. It analyses children’s rights law in the following areas: implementation and enforcement; advocacy and standard setting; complaints and remedies; the child and the family; adoption; alternative care; protection from violence; civil rights of the child; economic, social and cultural rights; education; health; migration and refugees; children and the justice system; children with disabilities; deprivation of liberty; children’s rights and digital technologies; war and disaster; sustainable development goals and further contemporary issues.

Social justice. --- Human Rights. --- Social Justice, Equality and Human Rights. --- International Humanitarian Law, Law of Armed Conflict. --- Equality --- Justice --- Children's rights. --- Convention on the Rights of the Child --- Child rights --- Children --- Children's human rights --- Children's rights --- Rights of children --- Rights of the child --- Human rights --- Civil rights --- Law and legislation --- Legal status, laws, etc. --- Adong Kwŏlli Hyŏbyak --- CIDE --- CDN --- Convenção sobre os Direitos da Criança --- Convención de los derechos de los niños --- Convención sobre los Derechos del Niño --- Convention des Nations Unies sur les droits de l'enfant --- Convention internationale des droits de l'enfant --- Convention Internationale relative aux droits de l'enfant --- Convention internationale sur les droits de l'enfant --- Convention of the Rights of the Child --- Convention on Rights of the Child --- Convention relative aux droits de l'enfant --- Convenția internațională cu privire la drepturile copilului --- Convenția cu privire la drepturile copilului --- Convenzione internazionale dei diritti del fanciullo --- Convenzione internazionale sui diritti dell'infanzia e dell'adolescenza --- Convenzione sui diritti del fanciullo --- Convenzione sui diritti dell'infanzia e dell'adolescenza --- CRC --- FN's konvention om barnets rettigheder --- Internationaal Verdrag inzake de Rechten van het Kind --- Ittifāqīyat al-Umam al-Muttaḥidah li-Ḥuqūq al-Ṭifl --- IVRK --- Jidō no kenri jōyaku --- Jidō no kenri ni kansusu jōyaku --- Kodomo no kenri jōyaku --- Kodomo no kenri ni kansuru jōyaku --- Konvensi Hak Anak --- Konvensi Hak-Hak Anak --- Konvensjon om barnets rettigheter --- Konvention om barnets rettigheder --- Konventionen om barnets rättigheter --- Konvent︠s︡ii︠a︡ o pravakh rebenka --- Konwencja o prawach dziecka --- Kunvānsiyūn-i Ḥuqūq-i Kūdak --- Lapsen oikeuksien yleissopimus --- Samningur Sameinuðu þjóðanna um réttindi barnsins --- Simiso Semalungelo Ebantfwana --- Übereinkommen über die Rechte des Kindes --- UN Convention on the Rights of the Child --- United Nations Convention on the Rights of the Child --- Convención de los derechos del niño

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Children --- Childhood --- Kids (Children) --- Pedology (Child study) --- Youngsters --- Age groups --- Families --- Life cycle, Human --- Legal status, laws, etc. --- Convention on the Rights of the Child --- Convention on the Rights of the Child. --- Africa, Portuguese-speaking. --- Adong Kwŏlli Hyŏbyak --- CIDE --- CDN --- Convenção sobre os Direitos da Criança --- Convención de los derechos de los niños --- Convención sobre los Derechos del Niño --- Convention des Nations Unies sur les droits de l'enfant --- Convention internationale des droits de l'enfant --- Convention Internationale relative aux droits de l'enfant --- Convention internationale sur les droits de l'enfant --- Convention of the Rights of the Child --- Convention on Rights of the Child --- Convention relative aux droits de l'enfant --- Convenția internațională cu privire la drepturile copilului --- Convenția cu privire la drepturile copilului --- Convenzione internazionale dei diritti del fanciullo --- Convenzione internazionale sui diritti dell'infanzia e dell'adolescenza --- Convenzione sui diritti del fanciullo --- Convenzione sui diritti dell'infanzia e dell'adolescenza --- CRC --- FN's konvention om barnets rettigheder --- Internationaal Verdrag inzake de Rechten van het Kind --- Ittifāqīyat al-Umam al-Muttaḥidah li-Ḥuqūq al-Ṭifl --- IVRK --- Jidō no kenri jōyaku --- Jidō no kenri ni kansusu jōyaku --- Kodomo no kenri jōyaku --- Kodomo no kenri ni kansuru jōyaku --- Konvensi Hak Anak --- Konvensi Hak-Hak Anak --- Konvensjon om barnets rettigheter --- Konvention om barnets rettigheder --- Konventionen om barnets rättigheter --- Konvent︠s︡ii︠a︡ o pravakh rebenka --- Konwencja o prawach dziecka --- Kunvānsiyūn-i Ḥuqūq-i Kūdak --- Lapsen oikeuksien yleissopimus --- Samningur Sameinuðu þjóðanna um réttindi barnsins --- Simiso Semalungelo Ebantfwana --- Übereinkommen über die Rechte des Kindes --- UN Convention on the Rights of the Child --- United Nations Convention on the Rights of the Child --- Convención de los derechos del niño