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This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact

hydrogel --- mechanical property --- network topology --- crosslinking --- biomaterials

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This book presents the latest development of fibre/ceramic-polymer composites for biocompatible applications, with a special emphasis on the effect of different types of fibre and ceramic fillers on the characteristics of the composites. The book contains chapters that cover fundamentals, materials used for composites, fabrication, classification, and biomedical applications. The first section of the book provides a brief overview of the fibre and ceramic-based composite materials while the subsequent sections cover the numerous types of fibre and ceramic polymeric composites with emphasis on their potential biomedical applications. Increasingly sophisticated biomedical technologies, such as tissue engineering and regenerative medicine, as well as genetic therapies and controlled drug delivery, are being developed at a breakneck pace, necessitating the development of new materials to meet the specific requirements of these fields. Single-component ceramic or polymer materials that are now available do not meet their requirements. Therefore, composites and hybrid composites have an important role to play. Aside from that, to completely meet the fundamental criteria such as biocompatibility, biodegradability, and acceptable mechanical qualities, it is necessary to find materials that can perform a variety of advanced activities at the same time. This book is a road map not only for the materials scientist but also for researchers, academics, technologists, and students working in composites for biomedical engineering applications.

Composite materials. --- Polymers. --- Biomaterials. --- Composites. --- Biomedical Materials.

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In this book, a summary and update of the most important areas of cell-penetrating peptides (CPP) research are presented, while raising relevant questions for further development. The CPP sequences are presented and discussed throughout the book. The methods for testing CPP mechanisms are discussed in detail. Various approaches for the testing of endocytotic pathways of CPP uptake are also described. Different CPP uptake experiments are compared since it is becoming clear that it is often best to apply several methods in a complementary manner in order to most comprehensively evaluate CPP uptake mechanisms due to the complexity of these processes. A brief summary of functionality issues of CPPs, both in vitro and in vivo, is discussed. Therapeutic potential of CPPs and commercial developments are discussed. The present, second edition of this book is the updated and expanded version of the first edition, published in 2019. The development of the field of cell-penetrating peptides in these five years has been obvious and exciting. This second edition of the book has been partly reorganized and comprehensively expanded with the exciting research in 2019-2023. Around 2500 novel scientific articles have become available, most of them are reviewed in the second edition. Additional rapidly growing areas of high impact presented in this second edition are therapeutic developments (Chapter 16) and delivery of oligonucleotides and proteins/peptides (Chapters 5 and 6) including novel reports on genome editing with CPP assistance. Also, several additional examples are available now on clinical trials using CPPs (Chapter 15). The book is written for researchers and students in the field.

Drug delivery systems. --- Proteins. --- Pharmacology. --- Medicinal chemistry. --- Biomaterials. --- Drug Delivery. --- Protein Biochemistry. --- Medicinal Chemistry. --- Biomaterials-Proteins.

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Cultivated meat is an emerging substitute for conventional meat that is not associated with animal farming and slaughtering. Instead, animal cells are cultivated in bioreactors and post-processed into “artificial” meat products. Although this new technology solves several ethical and environmental problems, there are techno-economic challenges that need to be addressed to make the commercial-scale production of cultivated meat a real perspective. This book addresses fundamental aspects of new food systems, animal cell culture and cultivated meat production, including cell lines, culture media, microcarriers and scaffolds, bioreactors, downstream processes, formulation, packaging, quality control, scale-up, and waste management. Also, aspects related to commercialization, market, patents, legislation, global and regional policies, and sustainability metrics such as life-cycle assessment, together with a bioeconomy perspective analysis, are reviewed. Finally, case studies are presented and the challenges and future prospects for cultivated meat production are proposed. This book is a collection of 20 chapters written by specialists in the field.

Proteins. --- Biomaterials. --- Animal biotechnology. --- Food science. --- Biomaterials-Proteins. --- Animal Biotechnology. --- Food Engineering. --- Cultured meat.

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Biomaterials are produced from biological material and are used for their physical characteristics. This book looks at the range of biomaterials and their applications which range from the use of polysaccharides as thickening agents to the use of proteins as fibres and adhesives.

Biotechnology. --- Biomaterials. --- Biocompatible materials --- Biomaterials --- Medical materials --- Medicine --- Biomedical engineering --- Materials --- Biocompatibility --- Prosthesis --- Chemical engineering --- Genetic engineering --- Bioartificial materials --- Hemocompatible materials --- Biomaterials (Biomedical materials) --- Biomedical materials.