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Bacterial toxins that act inside cells interact very specifically with key components of the cell and some even manipulate the cell in subtle ways for their own purposes. These potent toxins, described in this 2005 book, will be of interest to both microbiologists and cell biologists. Some of these toxins are conventional multidomain toxins that are self-programmed to enter cells. Others are delivered by type III mechanisms, often as a package of potent molecules. The molecular targets for all these toxins mediate signal transduction and the cell cycle to regulate the crucial processes of cell growth, cell division and differentiation. Thus these potent toxins are not only responsible for disease, but also provide a powerful set of tools with which to interrogate the biology of the cell. In addition such toxins may act directly to promote carcinogenesis and hence their study is also of interest in a wider context.

Bacterial toxins. --- Bacterial antigens --- Microbial toxins

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Alistair Lax reveals the panoply of ways in which bacterial toxins overcome the defences in our cells. He explains how they work, how they are so successful in causing major diseases and how humans can learn to combat them, and even harness them for beneficial purposes.

Bacterial toxins --- Bacterial antigens --- Microbial toxins --- 579.61 --- 615.9 --- bacteriële toxines --- bacteriën --- biologie --- geneeskunde --- microbiologie --- pathologie --- toxicologie --- toxines --- medische microbiologie --- algemene toxicologie --- Bacterial toxins.

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This book provides ample knowledge and better understanding of Streptococcus pyogenes and their superantigens. Many illustrations make this a highly informative book. This book elucidates briefly Streptococcus pyogenes as a strict human pathogen possessing an array of virulence factors. These help in evading host immune responses such as by the activation of non-specific T-cell subpopulations by producing superantigens. This book mainly focuses on streptococcal superantigens and explains how they are different from conventional antigens. Moreover, it elaborates those diseases in which superantigens are actively involved. Useful aspects of superantigens and different therapeutic interventions to eradicate superantigens induced diseased are also discussed.

Life Sciences. --- Microbiology. --- Life sciences. --- Sciences de la vie --- Microbiologie --- Streptococcus pyogenes. --- Superantigens. --- Biology --- Health & Biological Sciences --- Microbiology & Immunology --- Streptococcus hemolyticus --- Streptococcus --- Bacterial antigens --- Viral antigens --- Microbial biology --- Microorganisms

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A comprehensive compendium of scholarly contributions relating to bacterial virulence gene regulation.

Bacteria --- Bacterial genetics. --- Bacterial toxins. --- Bacteriophages --- Virulence (Microbiology) --- Virulence factors --- Microbial virulence --- Pathogenic microorganisms --- Bacteriophage --- Phages --- Viruses --- Lysogeny --- Transduction --- Bacterial antigens --- Microbial toxins --- Bacteriology --- Microbial genetics --- Germs --- Microbes --- Prokaryotes --- Pathogenicity. --- Physiology. --- Genetics

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This volume focuses on the transport of medically relevant bacterial protein toxins into mammalian cells, and on novel pharmacological strategies to inhibit toxin uptake. The first chapters review our current understanding of the cell-surface receptors and cellular transport processes of Clostridium botulinum neurotoxins, Clostridium botulinum C3 toxin, Clostridium difficile toxins, binary clostridial enterotoxins, anthrax toxins and diphtheria toxin. In brief, specific binding/transport (B) subunits deliver the enzyme (A) subunits into the cytosol, where the latter modify their substrates, producing cytotoxic effects and the characteristic toxin-associated diseases. Key mechanisms for the transport of the A subunits from endosomes into the cytosol and the role of trans-membrane pores formed by the B subunits and host cell chaperones for this process are reviewed. The book’s closing chapters focus on compounds which inhibit the transport of the A subunits from endosomes into the cytosol and therefore might lead to novel therapeutic strategies for toxin-associated diseases. These substances include pharmacological inhibitors of the host cell chaperones involved, as well as multivalent and heterocyclic molecules that specifically block the toxins’ translocation channels. This volume offers an up-to-date resource for scientists.

Medicine. --- Medical microbiology. --- Pharmacology. --- Infectious diseases. --- Biomedicine. --- Medical Microbiology. --- Pharmacology/Toxicology. --- Infectious Diseases. --- Drug effects --- Medical pharmacology --- Medical sciences --- Chemicals --- Chemotherapy --- Drugs --- Pharmacy --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Pathology --- Physicians --- Physiological effect --- Bacterial toxins. --- Bacterial antigens --- Microbial toxins --- Microbiology. --- Toxicology. --- Emerging infectious diseases. --- Emerging infections --- New infectious diseases --- Re-emerging infectious diseases --- Reemerging infectious diseases --- Communicable diseases --- Medicine --- Pharmacology --- Poisoning --- Poisons --- Microbial biology --- Biology --- Microorganisms --- Toxicology