Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Alzheimer's Disease is a finalist for a 2005 ForeWord Book of the Year Award! Click here to learn more about the ForeWord Book of the Year Awards. An estimated 5 million Americans suffer from Alzheimer's disease, only half of whom have been diagnosed. An uncertain but even larger number have mild cognitive impairment, often a precursor to Alzheimer's. By 2030, barring a cure for this illness, the number of individuals diagnosed with Alzheimer's disease is estimated to be 8 million, and by 2050, 14 million. The cost in both suffering and dollars on the part of patients and families is enormous

Alzheimer's disease

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Alzheimer's disease

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Advances in Alzheimer's disease (AD) research have been challenging and without major breakthroughs in understanding its pathological basis. The reigning hypothesis suggests AD is the result of extracellular amyloid deposition that seed to form amyloid plaques, which then grow and kill neighboring neurons. However, there are several inconsistencies with this hypothesis, not to mention the inability to show clinical benefit in several failed clinical trials by pharmaceuticals (i.e., from Pfizer, Eli Lilly, etc.), and it is in the field's best interest to explore and test multiple hypotheses fo

Alzheimer's disease --- Pathogenesis.

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

This Edited Volume Alzheimer's Disease is a collection of reviewed and relevant research chapters, offering a comprehensive overview of recent developments in the field. The book comprises single chapters authored by various researchers and edited by an expert in the field, working on Alzheimer's disease and dementia with cutting-edge technology. All chapters are complete in themselves but united under a common research study topic. This publication aims at providing a thorough overview of the latest research efforts by international authors in this research area, and opening new possible research paths for further novel developments.

Alzheimer's disease --- Diagnosis.

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Cancer, dementia, and cardiovascular disease are responsible for almost two million deaths each year in the United States alone and represent the largest immediate threat to humanity. Over the last century, we have made spectacular advances that have transformed our society - splitting the atom, space travel, telecommunications, and the Internet - but with medical research focused mostly on science for the sake of science, it has yielded precious few cures. A Roadmap for Curing Cancer, Alzheimer's, and Cardiovascular Disease represents a "first of its kind" effort to address both the reasons for this and to posit solutions to fix our broken system, in an effort to finally end this cure crisis. Dr. Marangos draws on 45 years of experience in every aspect of the biomedical R&D field, from basic drug discovery research at the NIH to the co-founding of five drug companies. He has published 252 research papers and edited four books on drug discovery, is co-inventor on 14 patents, and founded "The Journal of Molecular Neuroscience". He argues that from a development perspective, the regulatory, patent, and legal hurdles that force industry to pursue so-called "me-too" drugs rather than cures for terminal diseases must be re-thought. Leadership accountability, strategy, focus, and urgency need to be re-evaluated, and major reforms to the NIH, FDA, and patent codes are proposed.to remedy these impediments to cures. Written for anyone frustrated with the seemingly endless threat of terminal disease, this book seeks to inform, energize, and provide the rationale for the public and industry stakeholders, as well as clinicians and researchers, to resurrect the physician-patient relationship and demand that we get serious about ridding society of this scourge on humanity.--

Alzheimer's disease --- Treatment.