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Adrenaline. --- Adrenalin --- Epinephrine --- Bronchodilator agents --- Catecholamines --- Neurotransmitters --- Sympathomimetic agents --- Adrenergic mechanisms

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The adrenergic receptors control many critical functions of the heart, kidney, brain, and all organs under autonomic control. Today significant opportunities exist for molecular and genetic analysis of their function and signaling pathways. In The Adrenergic Receptors: In the 21st Century, senior scientists who have developed novel molecular approaches describe the state-of-the-art understanding of the structure and function of the adrenergic receptor subtypes, as well as the role played by these receptors in physiological and pathophysiological settings. Topics range from structure-function studies and the imaging of adrenergic receptors to the use of genetically altered mouse models and pharmacogenomics. Many of the methods described can be applied to characterize any receptor of interest. Highlights include a survey of the knockout and overexpressed mouse models, a review of the new ways that adrenergic receptors can signal, and the effects of polymorphisms on both clinical outcomes and potential gene therapy applications. Additional chapters address modern techniques for assessing adrenergic function, such as fluorescent labeling and microarrays, and offer an insightful historical survey of the extraordinary progress made in our understanding of these receptors in the twentieth century. Comprehensive and authoritative, The Adrenergic Receptors: In the 21st Century provides researchers-through its side-by-side comparison of all the adrenergic receptors (a1, a2, and b) and their subtypes-with an excellent survey of the field, including the rationale for how best to design better drugs for control of the heart, blood pressure, and related pathophysiological systems.

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Well before Evel Knievel or Hollywood stuntmen, reality television or the X Games, North America had a long tradition of stunt performance, of men (and some women) who sought media attention and popular fame with public feats of daring. Many of these feats-jumping off bridges, climbing steeples and buildings, swimming incredible distances, or doing tricks with wild animals-had their basis in the manual trades or in older entertainments like the circus. In The Thrill Makers, Jacob Smith shows how turn-of-the-century bridge jumpers, human flies, lion tamers, and stunt pilots first drew crowds to their spectacular displays of death-defying action before becoming a crucial, yet often invisible, component of Hollywood film stardom. Smith explains how these working-class stunt performers helped shape definitions of American manhood, and pioneered a form of modern media celebrity that now occupies an increasingly prominent place in our contemporary popular culture.

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