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There has been an explosion in the information available about protein structure. Principles of Protein Structure provides a comprehensive overview of this massive set of information. The authors use the known structures to illustrate the forces which determine protein structures, the rationale behind many of the features of organization of proteins, and the mechanisms by which proteins perform biological functions. This textbook surveys not only what is known, but also how the structural data can be organized and systematized and what it can be used for in chemical and biomedical research. The book includes what is probably the most comprehensive published bibliography on protein structure.
547.96 --- 547.96 Proteins --- Proteins --- Macromolecular Substances --- #WSCH:FYS3 --- 577.112 --- Proteids --- Biomolecules --- Polypeptides --- Proteomics --- 577.112 Proteins --- Gene Products, Protein --- Gene Proteins --- Protein Gene Products --- Proteins, Gene --- Molecular Mechanisms of Pharmacological Action --- Macromolecular Complexes --- Macromolecular Compounds --- Macromolecular Compounds and Complexes --- Complexes, Macromolecular --- Compounds, Macromolecular --- Substances, Macromolecular --- Nanostructures --- Proteins. --- Amino acid sequence --- Protéines --- Séquence des acides aminés --- Protéines --- Protéines. --- Séquence des acides aminés. --- aminozuur --- peptide --- proteine --- Protein --- Macromolecules --- Chemistry of natural organic substances --- General biochemistry --- Molecular biology --- fysicochemie --- Amino acid sequence.
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Probabilistic models are becoming increasingly important in analysing the huge amount of data being produced by large-scale DNA-sequencing efforts such as the Human Genome Project. For example, hidden Markov models are used for analysing biological sequences, linguistic-grammar-based probabilistic models for identifying RNA secondary structure, and probabilistic evolutionary models for inferring phylogenies of sequences from different organisms. This book gives a unified, up-to-date and self-contained account, with a Bayesian slant, of such methods, and more generally to probabilistic methods of sequence analysis. Written by an interdisciplinary team of authors, it aims to be accessible to molecular biologists, computer scientists, and mathematicians with no formal knowledge of the other fields, and at the same time present the state-of-the-art in this new and highly important field.
Nucleotide sequence --- Amino acid sequence --- Numerical analysis. --- Probabilities. --- Probability --- Statistical inference --- Combinations --- Mathematics --- Chance --- Least squares --- Mathematical statistics --- Risk --- Mathematical analysis --- Amino acid sequence analysis --- Analysis, Amino acid sequence --- Peptide sequence --- Peptide sequencing --- Protein sequence --- Protein sequencing --- Sequence, Amino acid --- Amino acids --- Proteins --- Sequence alignment (Bioinformatics) --- Analysis, Nucleic acid sequence --- Analysis, Nucleotide sequence --- Base sequence (Nucleic acids) --- DNA sequence --- Nucleic acid sequence analysis --- Nucleotide sequence analysis --- RNA sequence --- Sequence, Nucleotide --- Nucleic acids --- Nucleotides --- Statistical methods. --- Analysis --- Numerical analysis --- Probabilities --- 57.087 --- 57.087 Methods and techniques for parameter estimation. Recording of biological data --- Methods and techniques for parameter estimation. Recording of biological data --- Statistical methods --- 57.088 --- 577.112 --- 577.113 --- #TELE:SISTA --- 577.113 Nucleic acids --- 577.112 Proteins --- 57.088 Special methods and techniques for studing biological molecules. Separation. Centrifuging. X-ray study. Radioisotope methods --- Special methods and techniques for studing biological molecules. Separation. Centrifuging. X-ray study. Radioisotope methods --- Séquence nucléotidique --- Séquence des acides aminés --- Analyse numérique --- Probabilités --- Méthodes statistiques --- Biomathematics. Biometry. Biostatistics --- Analytical biochemistry --- Nucleotide sequence - Statistical methods. --- Amino acid sequence - Statistical methods.
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The Phylogenetic Handbook is a broad, hands on guide to theory and practice of nucleotide and protein phylogenetic analysis. This second edition includes six new chapters, covering topics such as Bayesian inference, tree topology testing and the impact of recombination on phylogenies, as well as a detailed section on molecular adaptation. The book has a stronger focus on hypothesis testing than the previous edition, with more extensive discussions on recombination analysis, detecting molecular adaptation and genealogy-based population genetics. Many chapters include elaborate practical sections, which have been updated to introduce the reader to the most recent versions of sequence analysis and phylogeny software, including BLAST, FastA, Clustal, T-coffee, Muscle, DAMBE, Tree-puzzle, Phylip, MEGA, PAUP*, IQPNNI, CONSEL, ModelTest, Prottest, PAML, HYPHY, MrBayes, BEAST, LAMARC, SplitsTree, and RDP. Many analysis tools are described by their original authors, resulting in clear explanations that constitute an ideal teaching guide for advanced-level undergraduate and graduate students.
Evolution. Phylogeny --- Sequence Analysis, DNA --- Sequence Analysis, Protein --- Phylogenèse --- Models, Genetic. --- DNA phylogeny --- Amino Acid Sequence. --- -Proteins --- fylogenetica --- dna analyse --- 575.852 --- 575.852 Biomacromolecules. Molecular evolution --- Biomacromolecules. Molecular evolution --- Branching processes --- Amino Acid Sequences --- Sequence, Amino Acid --- Sequences, Amino Acid --- Protein Structure, Primary --- Primary Protein Structure --- Primary Protein Structures --- Protein Structures, Primary --- Structure, Primary Protein --- Structures, Primary Protein --- Phylogenies --- Models, genetic. --- Sequence analysis, dna --- Sequence analysis, protein --- Phylogenèse --- Phylogeny --- methods --- Computer programs. --- Amino acid sequence --- Cladistic analysis --- DNA --- Proteins --- Models, Genetic --- aminozuur --- dna --- proteine --- Academic collection --- 577.112 --- 577.212.3 --- 577.212.3 Nucleic acid base and sequence compositon. Experimental deciphering of genetic code. --- Nucleic acid base and sequence compositon. Experimental deciphering of genetic code. --- Classification --- Phylogeography --- Proteids --- Biomolecules --- Polypeptides --- Proteomics --- Deoxyribonucleic acid --- Desoxyribonucleic acid --- Thymonucleic acid --- TNA (Nucleic acid) --- Deoxyribose --- Nucleic acids --- Genes --- Cladism --- Cladistic method --- Cladistic taxonomy --- Cladistics --- Cladograms --- Phylogenetic systematics --- Phylogenetic taxonomy --- Taxonomy, Cladistic --- Taxonomy, Phylogenetic --- Biology --- Amino acid sequence analysis --- Analysis, Amino acid sequence --- Peptide sequence --- Peptide sequencing --- Protein sequence --- Protein sequencing --- Sequence, Amino acid --- Amino acids --- Sequence alignment (Bioinformatics) --- Genetic Models --- Genetic Model --- Model, Genetic --- 577.112 Proteins --- Data processing --- Analysis --- Nucleic acid base and sequence compositon. Experimental deciphering of genetic code --- Phylogenomics --- Phylogenomic --- Dna --- Phylogeny. --- Data processing. --- Methods. --- methods. --- Community Phylogenetics --- Molecular Phylogenetics --- Phylogenetic Analyses --- Phylogenetic Analysis --- Phylogenetic Clustering --- Phylogenetic Comparative Analysis --- Phylogenetic Comparative Methods --- Phylogenetic Distance --- Phylogenetic Generalized Least Squares --- Phylogenetic Groups --- Phylogenetic Incongruence --- Phylogenetic Inference --- Phylogenetic Networks --- Phylogenetic Reconstruction --- Phylogenetic Relatedness --- Phylogenetic Relationships --- Phylogenetic Signal --- Phylogenetic Structure --- Phylogenetic Tree --- Phylogenetic Trees --- Analyse, Phylogenetic --- Analysis, Phylogenetic --- Analysis, Phylogenetic Comparative --- Clustering, Phylogenetic --- Community Phylogenetic --- Comparative Analysis, Phylogenetic --- Comparative Method, Phylogenetic --- Distance, Phylogenetic --- Group, Phylogenetic --- Incongruence, Phylogenetic --- Inference, Phylogenetic --- Method, Phylogenetic Comparative --- Molecular Phylogenetic --- Network, Phylogenetic --- Phylogenetic Analyse --- Phylogenetic Clusterings --- Phylogenetic Comparative Analyses --- Phylogenetic Comparative Method --- Phylogenetic Distances --- Phylogenetic Group --- Phylogenetic Incongruences --- Phylogenetic Inferences --- Phylogenetic Network --- Phylogenetic Reconstructions --- Phylogenetic Relatednesses --- Phylogenetic Relationship --- Phylogenetic Signals --- Phylogenetic Structures --- Phylogenetic, Community --- Phylogenetic, Molecular --- Reconstruction, Phylogenetic --- Relatedness, Phylogenetic --- Relationship, Phylogenetic --- Signal, Phylogenetic --- Structure, Phylogenetic --- Tree, Phylogenetic --- Molecular evolution --- Nucleotides --- Nucleotide sequence --- Molecular aspects --- DNA - Analysis - Handbooks, manuals, etc --- Proteins - Analysis - Handbooks, manuals, etc --- Cladistic analysis - Handbooks, manuals, etc --- Amino acid sequence - Data processing
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