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Recent studies in human genetics and in silico analyses have revealed that a number of genes are head-head orientated with other genes or non-coding RNAs. The expression of regulatory element-containing 5’-upstream regions of gene pairs are referred to as bi-directional promoters and are thought to have a key role in biological regulatory mechanisms. For example, tumor suppressor protein-encoding TP53 and BRCA1 genes are head-head bound with WRAP53 and NBR2, respectively. DNA-repair factor-encoding ATM and PRKDC (DNA-PKcs) genes have bidirectional partner NPAT and MCM4, respectively. Surveillance of the human DNA database has revealed that the numbers of DNA repair/mitochondrial function/immune response-associated genes are bound with other genes that are transcribed to opposite direction. The observations may encourage us to investigate in the molecular mechanisms how DNA repair/mitochondrial function/immune response-associated genes are regulated by bidirectional promoters. Not only protein-coding genes, but also quite a few ncRNAs, which play important roles in various cellular events, are transcribed under the regulation of the bidirectional promoters. More importantly, we know that dysregulation in the promoter activity and transcription initiation of genes might cause human diseases.
Promoters (Genetics) --- Genetic transcription --- Nucleotides --- Operons --- Transcription, Genetic --- Promoter Regions, Genetic
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Provides the most comprehensive listing of the hazardous chemicals commonly used, transported, and regulated in industry and the workplace. The chemicals are presented alphabetically and classified as a carcinogen, hazardous substance, hazardous waste, or toxic pollutant.
Toxicology --- Industrial toxicology --- Carcinogens --- Cancer causing agents --- Carcinogenic agents --- Oncogens --- Hazardous substances --- Carcinogen --- Oncogen --- Tumor Initiator --- Tumor Initiators --- Tumor Promoter --- Tumor Promoters --- Initiator, Tumor --- Initiators, Tumor --- Promoter, Tumor --- Promoters, Tumor --- Benzidines --- Evidence Based Toxicology --- Evidence-Based Toxicology --- Toxinology --- Based Toxicologies, Evidence --- Based Toxicology, Evidence --- Evidence Based Toxicologies --- Evidence-Based Toxicologies --- Toxicologies, Evidence Based --- Toxicologies, Evidence-Based --- Toxicology, Evidence Based --- Toxicology, Evidence-Based --- Pharmacogenetics
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With contributions from experts in supported metal catalysis from both the industry and academia, this book presents the latest developments in characterization and application of supported metals in heterogeneous catalysis. In addition to thorough and updated coverage of the traditional aspects of heterogeneous catalysis such as preparation, characterization and use in well-established technologies such as vehicle emission control, the book also includes emerging areas where supported metal catalysis will make significant contributions to future developments, such as fuel cells and fine chemi
Metal catalysts. --- Catalysis. --- Catalyst supports. --- Metal catalysts --- Catalysis --- Catalyst supports --- Chemistry --- Physical Sciences & Mathematics --- Physical & Theoretical Chemistry --- Carriers (Chemistry) --- Catalyst carriers --- Inducing catalysts --- Promoters (Chemistry) --- Supports, Catalyst --- Catalysts --- Activation (Chemistry) --- Chemistry, Physical and theoretical --- Surface chemistry
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Metal catalysts --- Catalysis --- Catalyst supports --- Métaux --- Catalyse --- Supports de catalyseur --- Congresses --- Catalyseurs --- Congrès --- Chemistry --- Physical Sciences & Mathematics --- Physical & Theoretical Chemistry --- Carriers (Chemistry) --- Catalyst carriers --- Inducing catalysts --- Promoters (Chemistry) --- Supports, Catalyst --- Catalysts
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Focuses on molecular aspects of the mechanisms involved in chemical, physical, and viral (biological) carcinogenesis. Areas of interest include, but are not limited to, the structure, expression, or function of genes or gene products associated with normal growth and differentiation and alterations in neoplasia; characterization of genes or gene products expressed in preneoplastic or neoplastic cells; molecular studies that define a specific function of a tumor-associated protein or its effects on cellular function; virtually all research on molecular aspects of oncogenes, tumor suppressor genes, and their gene products; carcinogenesis studies in transgenic mice; and research on human tumor viruses.
Carcinogenesis --- Cancérogenèse --- Molecular aspects --- Aspect moléculaire --- Périodiques. --- Molecular aspects. --- Molecular carcinogenesis --- Cancer --- Oncogenesis --- Pathogenesis of cancer --- Tumorigenesis --- Pathogenesis --- Pathology, Molecular --- Pathology --- Genetic toxicology --- Carcinogens --- Molecular Biology --- Biochemical Genetics --- Biology, Molecular --- Genetics, Biochemical --- Genetics, Molecular --- Molecular Genetics --- Biochemical Genetic --- Genetic, Biochemical --- Genetic, Molecular --- Molecular Genetic --- Genetic Phenomena --- Carcinogen --- Oncogen --- Oncogens --- Tumor Initiator --- Tumor Initiators --- Tumor Promoter --- Tumor Promoters --- Initiator, Tumor --- Initiators, Tumor --- Promoter, Tumor --- Promoters, Tumor --- Benzidines --- Carcinogens. --- Cancérogènes. --- Periodicals. --- Cancer causing agents --- Carcinogenic agents --- Hazardous substances
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Carcinogenesis --- Cancer --- Cancérogenèse --- Periodicals --- Périodiques --- Mutagenesis --- Cell Transformation, Neoplastic. --- Carcinogens. --- Carcinogenesis. --- Mutagenesis. --- Cancer. --- Health. --- Health --- Oncogenesis --- Pathogenesis of cancer --- Tumorigenesis --- Oncogens --- Tumor Initiators --- Tumor Promoters --- Initiators, Tumor --- Promoters, Tumor --- Neoplastic Cell Transformation --- Transformation, Neoplastic Cell --- Tumorigenic Transformation --- Neoplastic Transformation, Cell --- Cell Neoplastic Transformation --- Cell Neoplastic Transformations --- Cell Transformations, Neoplastic --- Neoplastic Cell Transformations --- Neoplastic Transformations, Cell --- Transformation, Cell Neoplastic --- Transformation, Tumorigenic --- Transformations, Cell Neoplastic --- Transformations, Neoplastic Cell --- Transformations, Tumorigenic --- Tumorigenic Transformations --- Pathogenesis --- carcinogenesis --- chemoprevention --- mutagenesis --- enetics --- cancer prevention --- epidemiology --- Mutation (Biology) --- Radiogenetics --- Teratogenesis --- Pathology --- Genetic toxicology --- Benzidines --- Cell Line, Transformed --- Health Sciences --- Life Sciences --- Diagnostics --- Genetics --- Immunology --- Oncology --- Oncology. Neoplasms --- Carcinogen --- Oncogen --- Tumor Initiator --- Tumor Promoter --- Initiator, Tumor --- Promoter, Tumor
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Mutation --- Genetics, Medical --- Oncogens --- Genomics --- Oncogenes --- Mutation (Biology) --- Cancer --- Oncogènes --- Mutation (Biologie) --- Génomique --- genetics --- Periodicals. --- Périodiques --- Genetics, Medical. --- Carcinogens. --- Genomics. --- Cancer. --- Oncogenes. --- genetics. --- Oncology. --- Genome research --- Genomes --- Cancers --- Carcinoma --- Malignancy (Cancer) --- Malignant tumors --- Tumor Initiators --- Tumor Promoters --- Initiators, Tumor --- Promoters, Tumor --- Human Genetics --- Medical Genetics --- Genetics, Human --- Onc genes --- Research --- Genetics --- Variation (Biology) --- Molecular genetics --- Tumors --- Human Genome Project --- Genome --- Benzidines --- Anthropology, Physical --- Chromosome Disorders --- Sex Chromosome Disorders --- Genetic Diseases, Inborn --- Molecular Medicine --- Cancer genes --- Proto-oncogenes --- Comparative Genomics --- Comparative Genomic --- Genomic, Comparative --- Genomics, Comparative --- Oncology --- Carcinogen --- Oncogen --- Tumor Initiator --- Tumor Promoter --- Initiator, Tumor --- Promoter, Tumor
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Oncology. Neoplasms --- Carcinogenesis --- Mutagens --- Teratogenic agents --- Teratogens. --- Mutagens. --- Carcinogens. --- Carcinogenesis. --- Teratogenic agents. --- Teratogenese. --- Health Sciences --- Life Sciences --- Oncology --- Cytology, Cell Biology --- Toxicology --- Zoology --- Teratogens --- Mutagenic agents --- Cancer --- Oncogenesis --- Pathogenesis of cancer --- Tumorigenesis --- Oncogens --- Tumor Initiators --- Tumor Promoters --- Initiators, Tumor --- Promoters, Tumor --- Clastogens --- Genotoxins --- Embryotoxins --- Fetotoxins --- Pathogenesis --- Abnormalities, Human --- Teratogenesis --- Mutagenesis --- Mutation (Biology) --- Pathology --- Genetic toxicology --- Benzidines --- Carcinogens --- Mutation --- Abnormalities, Drug-Induced --- Etiology --- Carcinogen --- Oncogen --- Tumor Initiator --- Tumor Promoter --- Initiator, Tumor --- Promoter, Tumor --- Clastogen --- Genotoxin --- Mutagen --- Teratogen --- teratogens. --- carcinogens. --- mutagens. --- clastogens --- genotoxins --- toxic substances --- DNA damage --- genotoxicity --- induced mutation --- mutagenesis --- mutation --- carcinogenic agents --- carcinogenic compounds --- carcinogenic factors --- aflatoxin M2 --- aflatoxins --- anticarcinogenic activity --- anticarcinogenic agents --- asbestos --- carcinogenesis --- carcinogenicity --- carcinosarcoma --- haloacetic acids --- nitrosamines --- nitroso compounds --- safrole --- sterigmatocystin --- embryotoxins --- fetotoxins --- anabasine --- polychlorinated dibenzodioxins --- T-2 toxin --- teratogenicity
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Wanneer onderzoekers ziekten en andere lichamelijke afwijkingen bestuderen, komen ze vaak veel aan de weet over dewetmatigheden van normale levensprocessen. Dat gaat zeker op bij pogingen om de oorzaken van kanker te achterhalen. Dat onderzoek heeft allerlei inzichten opgeleverd over de normale vermeerdering en ontwikkeling van cellen. Deze verhelderingen en de bijdragen daarvan in de strijd tegen kanker vormen de kern van dit uniek boek. Celdeling en kanker is geschreven door twee vooraanstaande en vermaarde biomedische onderzoekers: Harold Varmus en Robert Weinberg. Zij laten zien hoe bepaalde inzichten in het verschijnsel kanker ons begrip van normale biologische functies hebben verhelderd. Wat verstoort nu eigenlijk de fundamentele regelmechanismen van celgroei, en waardoor ontstaat de onbelemmerde, onvoorspelbare woekering die kenmerkend is voor het begin van kanker? In Celdeling en kanker lezen we hoe onderzoekers deze vragen hebben verkend door het ontstaan van kanker, de carcinogenese, tot in de vroegst waarneembare, submicroscopische stadia te volgen. Puttend uit klassieke en recente onderzoeksresultaten, leggen de auteurs uit hoe erfelijke aanleg kan samengaan met andere factoren (zoals zonlicht, straling, tabak of bepaalde virusinfecties) waardoorde genetische code radicaal verandert en een normaal gen in een kankerverwekkend gen verandert. Varmus en Weinberg beschrijven wat er bekend is over de werking van genen die kanker lijken te bevorderen (de oncogenen) en van tumor-suppressorgenen, die het optreden van tumoren juist voorkomen en inperken. De auteurs besluiten met een vooruitblik op mogelijke manieren om kanker te beheersen, gebaseerd op huidige vorderingen in het onderzoek. Dit boek is een verslag van de frontlinies van een van de belangrijkste en boeiendste wetenschappelijke ondernemingen van deze tijd. Door te lezen over het onderzoek naar het ontstaan, de aard en de mechanismen van kanker krijgt men meer inzicht in de natuurlijke ontwikkeling [onvolledig]
Molecular biology --- Oncology. Neoplasms --- Carcinogens. --- Oncogenes. --- Cell Transformation, Neoplastic. --- Cancer cells --- 001 wetenschappen --- 616-006 --- 616-008 --- celdeling --- genetica --- kanker --- oncologie --- 600.2 --- 605.91 --- DNA --- biologie --- celdelingen --- erfelijkheidsleer --- exacte wetenschappen --- geneeskunde --- gezondheidszorg --- kwaadaardige gezwellen --- proto-oncogenen --- therapie --- tumor-suppressorgenen --- 616 --- Celdeling --- Kanker --- kwaadaardige gezwellen (kanker, sarcoom) --- oncologie (gezwelziekten) --- Celbiologie en kanker --- Cells --- Pathology, Cellular --- Neoplastic Cell Transformation --- Transformation, Neoplastic Cell --- Tumorigenic Transformation --- Neoplastic Transformation, Cell --- Cell Neoplastic Transformation --- Cell Neoplastic Transformations --- Cell Transformations, Neoplastic --- Neoplastic Cell Transformations --- Neoplastic Transformations, Cell --- Transformation, Cell Neoplastic --- Transformation, Tumorigenic --- Transformations, Cell Neoplastic --- Transformations, Neoplastic Cell --- Transformations, Tumorigenic --- Tumorigenic Transformations --- Cell Line, Transformed --- Oncogene --- Transforming Gene --- Transforming Genes --- Gene, Transforming --- Genes, Transforming --- Oncogens --- Tumor Initiators --- Tumor Promoters --- Initiators, Tumor --- Promoters, Tumor --- Benzidines --- Neoplasms --- Erfelijkheidsleer --- Oncologie --- (zie ook: endocrinologie, gynecologie, hematologie) --- Carcinogenesis --- Oncogenes --- CELL TRANSFORMATION, NEOPLASTIC --- Kanker. --- Carcinogenesis. --- CELL TRANSFORMATION, NEOPLASTIC. --- Cell transformation, neoplastic. --- Carcinogens --- Cell Transformation, Neoplastic --- Carcinogen --- Oncogen --- Tumor Initiator --- Tumor Promoter --- Initiator, Tumor --- Promoter, Tumor
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Antimicrobial resistance is a global One Health topic that affects us all, whether we are working in human or veterinary medicine. Although antibiotic use in farm animals is decreasing in many countries, other nations are still using these essential medical resources as growth promoters to boost economic gains. As veterinarians responsible for animal welfare, it is vital that we are permitted to treat sick animals effectively, but we must learn to be more prudent in our use of these drugs. It is essential that we, as responsible clinicians, policy makers, and researchers, develop methods of quantifying, monitoring, benchmarking, and reporting antibiotic use in both farm and companion animals, so that antimicrobial stewardship schemes can be implemented and their successes or failures analyzed. This Special Issue includes research on antibiotic use and resistance in a variety of animal species, covering cattle, sheep, pigs, poultry, and pets. The relationship between antimicrobial use and resistance in animals is investigated on a global scale, with authors from Austria, Australia, Brazil, Germany, Italy, India, the Netherlands, Peru, Portugal, Slovenia, and the United Kingdom.
Escherichia coli --- antimicrobial resistance --- swine --- weaned piglet --- antibiotic growth promoters --- antibiotic --- antibiotic resistance --- livestock --- antibiotic use --- AMR --- MDR --- environment --- antimicrobial usage --- bovine --- India --- KAP survey --- veterinarians --- antimicrobial use --- antimicrobial resistance (AMR) --- Timor-Leste --- antimicrobial --- veterinary --- prudent use --- critically important antimicrobials --- growth promotion --- poultry --- sheep --- beef cattle --- normalised resistance interpretation --- antimicrobial susceptibility testing --- tetracyclines --- farms --- turkeys --- farm --- antimicrobial resistance genes --- biosecurity --- risk factor --- metagenomics --- qPCR --- isolates --- neonatal calf diarrhea --- survey --- antibiotics --- HPCIA --- urinary tract infection --- Flexicult Vet --- pathogen identification --- dogs --- cats --- veterinary microbiology --- bovine respiratory disease --- multidrug-resistance --- Pasteurella multocida --- Mannheimia haemolytica --- Truperella pyogenes --- dairy farm --- E. coli --- calves --- enteritis --- serotypes --- virulence --- multidrug-resistant --- extensively drug-resistant --- dairy --- ESBL --- MRSA --- dog --- canine parvovirus --- Carnivore protoparvovirus 1 --- multidrug resistance --- One Health --- Enterobacteriaceae --- public awareness --- farmworkers --- chicken --- growth promoters --- Staphylococcus hyicus --- PFGE --- exudative epidermitis --- pigs --- monitoring --- carbapenems --- CPE --- meat-producing animal --- companion animal --- travelers --- feed --- risk assessment --- introduction risk --- stochastic risk model --- coagulase-negative Staphylococcus --- CoNS --- quails --- broilers
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