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Book
Year: 2017 Publisher: Frontiers Media SA
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Plant gene transfer achieved in the early ‘80s paved the way for the exploitation of the potential of gene engineering to add novel agronomic traits and/or to design plants as factories for high added value molecules. For this latter area of research, the term "Molecular Farming" was coined in reference to agricultural applications in that major crops like maize and tobacco were originally used basically for pharma applications. The concept of the “green biofactory” implies different advantages over the typical cell factories based on animal cell or microbial cultures already when considering the investment and managing costs of fermenters. Although yield, stability, and quality of the molecules may vary among different heterologous systems and plants are competitive on a case-to-case basis, still the “plant factory” attracts scientists and technologists for the challenging features of low production cost, product safety and easy scale up. Once engineered, a plant is among the cheapest and easiest eukaryotic system to be bred with simple know-how, using nutrients, water and light. Molecules that are currently being produced in plants vary from industrial and pharmaceutical proteins, including medical diagnostics proteins and vaccine antigens, to nutritional supplements such as vitamins, carbohydrates and biopolymers. Convergence among disciplines as distant as plant physiology and pharmacology and, more recently, as omic sciences, bioinformatics and nanotechnology, increases the options of research on the plant cell factory. “Farming for Pharming” biologics and small-molecule medicines is a challenging area of plant biotechnology that may break the limits of current standard production technologies. The recent success on Ebola fighting with plant-made antibodies put a spotlight on the enormous potential of next generation herbal medicines made especially in the name of the guiding principle of reduction of costs, hence reduction of disparities of health rights and as a tool to guarantee adequate health protection in developing countries.Plant gene transfer achieved in the early ‘80s paved the way for the exploitation of the potential of gene engineering to add novel agronomic traits and/or to design plants as factories for high added value molecules. For this latter area of research, the term "Molecular Farming" was coined in reference to agricultural applications in that major crops like maize and tobacco were originally used basically for pharma applications. The concept of the “green biofactory” implies different advantages over the typical cell factories based on animal cell or microbial cultures already when considering the investment and managing costs of fermenters. Although yield, stability, and quality of the molecules may vary among different heterologous systems and plants are competitive on a case-to-case basis, still the “plant factory” attracts scientists and technologists for the challenging features of low production cost, product safety and easy scale up. Once engineered, a plant is among the cheapest and easiest eukaryotic system to be bred with simple know-how, using nutrients, water and light. Molecules that are currently being produced in plants vary from industrial and pharmaceutical proteins, including medical diagnostics proteins and vaccine antigens, to nutritional supplements such as vitamins, carbohydrates and biopolymers. Convergence among disciplines as distant as plant physiology and pharmacology and, more recently, as omic sciences, bioinformatics and nanotechnology, increases the options of research on the plant cell factory. “Farming for Pharming” biologics and small-molecule medicines is a challenging area of plant biotechnology that may break the limits of current standard production technologies. The recent success on Ebola fighting with plant-made antibodies put a spotlight on the enormous potential of next generation herbal medicines made especially in the name of the guiding principle of reduction of costs, hence reduction of disparities of health rights and as a tool to guarantee adequate health protection in developing countries.
plant molecular farming --- Metabolic Engineering --- transient expression --- Genetic Engineering --- recombinant protein --- biopharmaceuticals --- Plant factory --- Biobetter
Book
Year: 2020 Publisher: Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute
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In recent years, the industrial environment has been changing radically due to the introduction of concepts and technologies based on the fourth industrial revolution, also known as Industry 4.0. After the introduction of Industry 4.0 in large enterprises, SMEs have moved into the focus, as they are the backbone of many economies. Small organizations are increasingly proactive in improving their operational processes, which is a good starting point for introducing the new concepts of Industry 4.0. The readiness of SME-adapted Industry 4.0 concepts and the organizational capability of SMEs to meet this challenge exist only in some areas. This reveals the need for further research and action plans for preparing SMEs in a technical and organizational direction. Therefore, special research and investigations are needed for the implementation of Industry 4.0 technologies and concepts in SMEs. SMEs will only achieve Industry 4.0 by following SME-customized implementation strategies and approaches and realizing SME-adapted concepts and technological solutions. Thus, this Special Issue represents a collection of theoretical models as well as practical case studies related to the introduction of Industry 4.0 concepts in small- and medium-sized enterprises.
latent semantic analysis --- virtual quality management --- concept investigation --- concept disambiguation --- knowledge discovery --- sustainable methodologies --- small and medium sized enterprises --- material handling systems --- simulation --- ARENA®, time study --- overall equipment effectiveness --- manufacturing performance --- Industry 4.0 --- manufacturing sustainability --- manufacturing process model --- business process management --- hierarchical clustering --- similarity --- BPMN --- human factors --- cyber-physical systems --- cyber-physical production systems --- anthropocentric design --- Operator 4.0 --- human–machine interaction --- energy efficient operation --- manufacturing system --- stochastic event --- digital twin --- Max-plus Algebra --- MATLAB-Simulink --- advanced manufacturing --- industry 4.0 --- SME --- technology adoption model --- assembly supply chain --- sustainability --- complexity indicators --- testing criteria --- SMEs --- e-business modelling --- LSP Lifecycle Model --- Quality Function Deployment --- Best-Worst Method --- Internet of Things --- India --- awareness --- small and medium-sized enterprises --- assessment model --- collaborative robotics --- physical ergonomics --- human-robot collaboration --- human-centered design --- assembly --- small and medium sized enterprise --- positive complexity --- negative complexity --- infeasible configurations --- product platform --- customer’s perception --- assessment --- field study --- smart manufacturing --- cloud platform --- artificial intelligence --- machine learning --- deep learning --- smart logistics --- logistics 4.0 --- smart technologies --- sustainable agriculture --- plant factory
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