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In 2015, the first pharmaceutical cocrystal was approved by the FDA. Since then, the number of cocrystals on the market and in the development pipeline has been slowly but steadily growing. It is now well established that cocrystals are a versatile new approach to oral drug formulation. This Reprint Book is a collection of articles that show the utility of pharmaceutical cocrystals and various aspects of cocrystal research: • Cocrystals as a strategy to modify the physicochemical properties of a drug such as dissolution behaviour, tabletability, and melting point; • Development of new coformers; • Screening studies for multiple cocrystal forms; • Cocrystals in nano-sized drug delivery.

nitazoxanide --- cocrystals --- multicomponent crystals --- dissolution behavior --- supersaturated formulations --- crystallization inhibitors --- drug-polymer interactions --- nano co-crystals --- crystal engineering --- polydispersity index --- zeta potential --- particle size --- zidovudine --- lamivudine --- HIV/AIDS --- sonochemistry --- imidazole N-oxides --- barbituric acid --- thiobarbituric acid --- pharmaceutical cocrystals --- mechanochemistry --- solid state NMR --- X-ray Diffraction --- design of experiments --- Quality by Design --- cocrystal --- compaction --- nanoindentation --- slip plane --- tabletability --- surface topology --- interparticulate bonding area --- interparticulate bonding strength --- nefiracetam --- solid state --- solubility --- dissolution rate --- stability --- formulation --- diclofenac sodium --- L-proline --- salt cocrystal --- multicomponent crystal --- monohydrate --- tetrahydrate --- dissolution --- itraconazole --- terephthalic acid --- crystal structure --- solid-state --- thermal analysis --- wettability --- n/a

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This Special Issue is result of a call for papers of the Section Industrial Crystallization of MDPI’s scientific journal Crystals. It addresses scientists and engineers active in research and process & product development in life-science industries (e.g. pharmaceuticals, fine chemicals and biotechnology products) and bulk chemical applications (e.g. desalination) as well. The contributions comprise several fundamental and application-oriented facets of crystallization providing an overview of industrially relevant subjects in the field. Main issues cover phase equilibria and solid-state behavior of crystalline compounds, crystal shape and size and related measurement techniques. Melt and solution crystallization are considered specifically addressing contemporary aspects of continuous crystallization and process intensification.

K-MER zeolite --- synthesis parameter --- morphology --- cyanoethylation of methanol --- catalyst --- multi-dendrite motion --- CA-LBM model --- dendritic growth --- natural convection --- numerical simulation --- melt crystallization --- freeze crystallization (FC) --- recycling --- ionic liquid (IL) --- solid–liquid equilibrium --- cellulose --- nanocrystals --- modification --- poly(butylene succinate) --- crystallization --- kinetics --- chirality --- deracemization --- preferential crystallization --- racemic conglomerate --- phase behavior --- polymorphism --- aryl glycerol ethers --- spherical BaTiO3 nanoparticle --- hydrothermal synthesis --- nanoscale TiO2 seed --- crystal growth --- dielectric property --- curcumin --- purification --- ternary mixture of curcuminoids --- reverse osmosis --- membrane fouling --- gypsum scaling --- fluorescent-tagged polyacrylate --- fluorescence --- scale inhibition mechanisms --- solvent effect --- crystal habit --- aspect ratio --- molecular dynamics (MD) --- surface structure --- amine --- biocatalysis --- enzyme --- process intensification --- enantioselective --- fluidized bed --- continuous --- chiral separation --- racemate resolution --- enantiomer --- asparagine monohydrate --- fine chemicals --- continuous crystallization --- crystal shape --- process design --- DTB crystallizer --- scale up --- L-serine --- L-alanine --- enantiomers --- isomorphic miscibility --- thermal expansion --- PXRD --- TRPXRD --- optical measurement techniques --- crystal size measurement --- inline probe --- crystal needles --- microcrystals --- microplate --- grid scanning --- in situ data collection --- n/a --- solid-liquid equilibrium