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The various cell types have traditionally been recognized and classified according to their appearance in the light microscope following the process of fixing, processing, sectioning, and staining tissues that is known as histology. Classical histology has been augmented byimmunohistochemistry (the use of specific antibodies to stain particular molecular species in situ). Immunohistochemistry has allowed the identification of many more cell types than could be visualized by classical histology, particularly in the immune system and among the scattered hormone-secreting cells of the

Molecular genetics. --- Lungs --- Breast --- Immunohistochemistry. --- In situ hybridization. --- Cancer. --- Nucleic acid hybridization --- Immunohistology --- Histochemistry --- Immunochemistry --- Lung cancer --- Genetics --- Molecular biology

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Classical histology has been augmented by immunohistochemistry (the use of specific antibodies to stain particular molecular species in situ). Immunohistochemistry has allowed the identification of many more cell types than could be visualized by classical histology, particularly in the immune system and among the scattered hormone-secreting cells of the endocrine system. This book discusses all aspects of immunohistochemistry and in situ hybridization technologies and the important role they play in reaching a cancer diagnosis. It provides step-by-step instructions on the methods

Cancer --- Immunohistochemistry. --- In situ hybridization. --- Fluorescence in situ hybridization. --- Immunodiagnosis. --- FISH (Fluorescence in situ hybridization) --- Fluorescent in situ hybridization --- Fluorescence microscopy --- In situ hybridization --- Nucleic acid hybridization --- Immunohistology --- Histochemistry --- Immunochemistry --- Diagnosis --- Immunological aspects

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Devoted to research in immunological science and medicine from basic research to clinical research.

innate immunity and inflammation --- structural immunology --- autoimmunity and immunoregulation --- neuroimmunology --- immunopathology and immunohistology --- clinical/translational immunology --- Immunology --- Immunogenetics --- Periodicals --- Clinical/translational immunology --- reproductive immunology --- Genetics --- Immunity --- Serology --- Immunological aspects --- Genetic aspects --- Immunology. --- Immunobiology --- Life sciences

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This book provides a comprehensive, state-of-the-art account of the role of immunohistochemistry in the diagnosis of skin tumors, which is crucial given that overlapping histologic features and unusual morphologic changes can lead to considerable diagnostic uncertainty. The book reviews in detail the sensitivity and specificity of commonly available antibodies and their pattern of immunostaining. Readers will learn when to order antibodies and how to interpret findings. In addition, prognostic markers are evaluated and emphasis placed on the pitfalls commonly encountered when evaluating these neoplasms. The informative text is complemented by a wealth of superb images. Helpful histograms and algorithms are included, and clear guidance is provided on the application and interpretation of less commonly used antibodies and immunostains. With the emergence of many immunomarkers, immunohistochemistry has become a vital ancillary diagnostic tool in dermatopathology and an essential adjunct for the correct identification of skin neoplasms. Indeed, immunohistochemistry has replaced simple morphologic evaluation as the definitive diagnostic method for various tumor types. The complexity of some skin neoplasms makes it imperative that the role of immunohistochemistry in subtyping these conditions is clearly understood. Against this background, Applied Immunohistochemistry in the Evaluation of Skin Neoplasms will serve as an extremely valuable resource for practicing dermatopathologists and pathologists.

Medicine. --- Laboratory medicine. --- Dermatology. --- Pathology. --- Medicine & Public Health. --- Laboratory Medicine. --- Skin --- Immunohistochemistry. --- Tumors --- Diagnosis. --- Immunohistology --- Cutis --- Integument (Skin) --- Beauty, Personal --- Body covering (Anatomy) --- Histochemistry --- Immunochemistry --- Medical laboratories. --- Diagnosis, Laboratory --- Health facilities --- Laboratories --- Medicine --- Disease (Pathology) --- Medical sciences --- Diseases --- Medicine, Preventive --- Clinical medicine --- Clinical pathology --- Diagnostic laboratory tests --- Laboratory diagnosis --- Laboratory medicine --- Medical laboratory diagnosis --- Diagnosis --- Pathology

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Aimed at both beginners and experienced researchers unfamiliar with the technique, this book provides a concise and easy-to-understand guide to using immunohistochemistry. It identifies the proper place and purpose of each component of immunohistochemistry, emphasizes the components that are of critical importance, and explains the logistics of experimental approaches. Understanding the principles of immunohistochemistry allows for the identification and localization of protein targets and is of crucial use in the following experiments: · producing transgenic animals · studying the effects of drug treatments · electrophysiological studies · animal surgery · isolating and differentiating stem cells · super-resolution microscopy Immunohistochemistry for the Non-Expert is aimed at a wide audience, including molecular biologists, pharmacologists, immunologists, chemists, cell biologists, physiologists, and researchers involved with animal anatomy studies.

Biophysics --- Biology --- Health & Biological Sciences --- Immunohistochemistry. --- Antigens. --- Immunoglobulins. --- Antibodies --- Immune globulins --- Immune serum globulin --- Immunohistology --- Immunity --- Immunoglobulins --- Histochemistry --- Immunochemistry --- Blood proteins --- Globulins --- Plasma cells --- Antibody diversity --- Antigens --- Bacterial immunoglobulin-binding proteins --- Medicine. --- Monoclonal antibodies. --- Neurochemistry. --- Molecular Medicine. --- Antibodies. --- Biochemistry --- Neurosciences --- Antibodies, Monoclonal --- Monoclonal immunoglobulins --- Molecular cloning --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Health Workforce --- Molecular biology. --- Molecular biochemistry --- Molecular biophysics --- Biomolecules --- Systems biology