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Long acting injections and implants improve therapy, enhance patient compliance, improve dosing convenience, and are the most appropriate formulation choice for drugs that undergo extensive first pass metabolism or that exhibit poor oral bioavailability.  An intriguing variety of technologies have been developed to provide long acting injections and implants.  Many considerations need to go into the design of these systems in order to translate a concept from the lab bench to actual therapy for a patient.  This book surveys and summarizes the field.  Topics covered in Long Acting Injections and Implants include the historical development of the field, drugs, diseases and clinical applications for long acting injections and implants, anatomy and physiology for these systems, specific injectable technologies (including lipophilic solutions, aqueous suspensions, microspheres, liposomes, in situ forming depots and self-assembling lipid formulations), specific implantable technologies (including osmotic implants, drug eluting stents and microfabricated systems), peptide, protein and vaccine delivery, sterilization, drug release testing and regulatory aspects of long acting injections and implants. This volume provides essential information for experienced development professionals but was also written to be useful for scientists just beginning work in the field and for others who need an understanding of long acting injections and implants.  This book will also be ideal as a graduate textbook. Dr. Jeremy Wright is a Principal Engineer at the DURECT Corporation in Cupertino, California.  He has over 30 years of experience in the development of drug delivery systems.  He has been a key contributor to the development of implantable osmotic systems for veterinary and human use (DUROS®) and is currently involved in research and development of injectable depot systems.  Dr. Wright is the inventor on over 50 patents.   Dr. Diane J. Burgess is Distinguished Professor of Pharmaceutics, at the University of Connecticut.  Her research efforts focus on gene and drug delivery and she has over 140 refereed publications. Dr. Burgess was the 2010 President of the Controlled Release Society (CRS), the 2002 President of the American Association of Pharmaceutical Scientists (AAPS) and is a CRS, AAPS and an American Institute for Medical and Biological Engineering (AIMBE) fellow.  She  is editor of the International Journal of Pharmaceutics.

Injections. --- Implants, Artificial. --- Therapeutics. --- Medical treatment --- Therapy --- Treatment of diseases --- Treatments for diseases --- Clinical medicine --- Artificial implants --- Implants, Surgical --- Surgical implants --- Biomedical materials --- Prosthesis --- Surgery --- Jabs (Injections) --- Shots (Injections) --- Drugs --- Administration --- Drug Implants. --- Delayed-Action Preparations --- therapeutic use. --- Medicine. --- Pharmaceutical technology. --- Biomedicine general. --- Pharmaceutical Sciences/Technology. --- Pharmaceutical laboratory techniques --- Pharmaceutical laboratory technology --- Technology, Pharmaceutical --- Technology --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Health Workforce --- Biomedicine, general.

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Atlas of Implantable Therapies for Pain Management This atlas is an essential guide for all implanters, from beginners to the most advanced practitioners. The process of implanting and managing spinal cord stimulators, peripheral nerve stimulators, and intrathecal pumps, from the beginning through long-term management, is thoroughly discussed, as are the prevention and management of complications. Extensive photographs and detailed instructions make each segment a great learning event. The Atlas of Implantable Therapies for Pain Management is a “must-have” resource for any physician wishing to improve his or her skills in interventional pain treatment. ABOUT THE AUTHOR TIMOTHY DEER, MD, is President and Chief Executive Officer of the Center for Pain Relief in Charleston, West Virginia and Clinical Professor of Anesthesiology, West Virginia University School of Medicine, Morgantown. Dr. Deer is the immediate past Chair of the Committee on Pain Medicine for the American Society of Anesthesiologists; a member of the Boards of Directors of the American Academy of Pain Medicine and the American Society of Interventional Pain Physicians; and a member of the Board of Directors and The Executive Board of the International Neuromodulation Society. He is also Chairman of the Scientific Review Committee of the American Academy of Pain Medicine, Chairman of the Scientific Oversight Committee for Pain Medicine of the American Society of Anesthesiologists, and the current President of The West Virginia Society of Interventional Pain Physicians. He lectures widely on the topic of implantable therapies in pain management and is one of the most respected proponents of these therapies worldwide.

Pain -- Popular works. --- Pain. --- Electrotherapeutics --- Electrodes, Implanted --- Infusion Pumps --- Sensation --- Neurologic Manifestations --- Delayed-Action Preparations --- Therapeutics --- Investigative Techniques --- Publication Formats --- Physical Therapy Modalities --- Signs and Symptoms --- Dosage Forms --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Publication Characteristics --- Artificial Organs --- Pathological Conditions, Signs and Symptoms --- Psychophysiology --- Prostheses and Implants --- Nervous System Diseases --- Electrodes --- Nervous System Physiological Processes --- Equipment and Supplies --- Surgical Equipment --- Pharmaceutical Preparations --- Diseases --- Psychological Phenomena and Processes --- Nervous System Physiological Phenomena --- Electrical Equipment and Supplies --- Specialty Uses of Chemicals --- Atlases --- Pain --- Infusion Pumps, Implantable --- Implantable Neurostimulators --- Drug Implants --- Electric Stimulation Therapy --- Methods --- Chemical Actions and Uses --- Musculoskeletal and Neural Physiological Phenomena --- Chemicals and Drugs --- Psychiatry and Psychology --- Phenomena and Processes --- Medicine --- Health & Biological Sciences --- Surgery & Anesthesiology --- Anesthesiology --- Occupational Therapy & Rehabilitation --- Pathology --- Neural stimulation. --- Electric stimulation. --- Treatment. --- Pain management --- Stimulation, Electric --- Nerve stimulation --- Stimulation, Neural --- Medicine. --- Anesthesiology. --- Neurology. --- Neurosurgery. --- Pain medicine. --- Medicine & Public Health. --- Pain Medicine. --- Electricity in medicine --- Electrophysiology --- Electric stimulation --- Electrodiagnosis --- Pain medicine --- Nervous system --- Neuropsychiatry --- Nerves --- Neurosurgery --- Anaesthesiology --- Surgery --- Algiatry --- Neurology .