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With Cholesterol, Drs. Anna Bukiya and Alex Dopico have compiled a comprehensive resource on biological and clinical aspects of cholesterol, spanning biophysics and biochemistry, as well as the latest pharmacological discoveries employed to tackle disorders associated with abnormal cholesterol levels. Early chapters on basic biology offer guidance in cholesterol lab chemistry, cholesterol metabolism and synthesis, molecular evolution of cholesterol and sterols, cholesterol peptides, and cholesterol modulation. Chapters on cellular and organismal development discuss cholesterol transport in blood, lipoproteins, and cholesterol metabolism; cholesterol detection in the blood; cellular cholesterol levels; hypercholesterolemia; and the role of cholesterol in early human development. Pathophysical specialists consider familial hypobetalipoproteinemia, critical illness and cholesterol levels, coronary artery disease, CESD, cholesterol and viral pathology, cholesterol and neurodegenerative disorders, and cholesterol and substance use disorders. A final section examines pharmacology of drug delivery systems targeting cholesterol related disorders, cholesterol receptors, cholesterol reduction, statins, citrate lyase, cyclodextrins, and clinical management.

Cholesterol. --- Isopentenoids --- Sterols --- Low-cholesterol diet --- Cholesterin --- Cholesterol

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""What is this cholesterol?"" In this book entitled ""Cholesterol- Good, Bad, and the Heart"" now you got the answers given by the experts in the field. Moreover, you can explore more by reading the references/citations given in the articles of each chapter. It is still an emerging field and lot more is being discovered. You will be amazed how much knowledge is already there in this book on cholesterol. You will realize that cholesterol is an essential and extremely important building block of cell membranes and thus serves vital functions in the body. I believe this book will be incredibly powerful and useful in teaching to give new perspectives on cholesterol.

Cholesterol. --- Cholesterin --- Isopentenoids --- Sterols --- Low-cholesterol diet --- Medicine --- Cardiology and Cardiovascular Medicine --- Health Sciences

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In België en Nederland nemen 3,5 miljoen mensen dagelijks het cholesterolverlagend middel statine. De meesten nemen statine omdat hun ?cholesterol? te hoog is, niet omdat ze een hart- of vaatziekte hebben. Een groep wetenschappers, artsen en cardiologen maakt zich hierover zorgen. Waarom moeten gezonde mensen dagelijks een statinepil nemen? Is het bewezen dat cholesterol onze aders dichtslibt? Krijgen we een te hoge cholesterol van verzadigde vetten? Waarom krijgen ook mensen met een lage cholesterolwaarde een hartinfarct? Waarom stopt bijna de helft van de mensen die een statine krijgt voorgeschreven na een jaar met de medicatie? Waarom halen zo weinig mensen de aanbevolen streefwaarde voor hun ?cholesterol?? Waarom waarschuwen wetenschappers voor mogelijke neurologische en motorische bijwerkingen van statines? In dit boek gaat journalist Ben Vanheukelom op zoek naar antwoorden. Hij praat met statinegebruikers, oud-gebruikers, experts, voor- en tegenstanders van de cholesterolhypothese en probeert een klare lijn te zien in het kluwen van duizenden wetenschappelijke artikels over cholesterol. https://www.maklugarant.eu/nl/products/details/cholesterol-de-verkeerde-vijand-242494

Cholesterol --- Hart- en vaatziekte --- Preventie --- Pathology of the circulatory system --- cholesterol --- cardiologie --- Gezondheidsaspecten

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Using natural products and developing pharmaceutical drugs are emerging topics to reduce blood cholesterol levels for preventing heart disease and stroke. Covering recent progresses in cholesterol-lowering drugs and therapy, this book describes the natural and pharmaceutical products that are in clinical uses to lower cholesterol and lipids and compares these drugs in responses to different diseases such as homozygous familial hypercholesterolemia, atherosclerosis, cardiovascular disease, and cancer. The relationship between ethnicity and cholesterol-lowering drug responses is also reviewed. Each chapter is a building block for the book, but each individual chapter is also a complete subject package for the readers. Researchers from basic and clinic science interested in lipid and cholesterol metabolism, regulation, and lowering will find this book very useful. Features: - Up-to-date information of the molecular mechanisms of cholesterol lowering, the drugs from natural and pharmaceutical products, and their associated therapeutic strategies in human diseases. - Discussion of the pathogenesis of several human diseases, which are associated with high cholesterol levels and evaluation of the results of different cholesterol-lowering drug treatment in these diseases. - Discussion of the combinations of cancer chemotherapy and cholesterol lowering in potential cancer treatment and cancer prevention by cholesterol-lowering drugs. - Critical analysis of the effect of ethnicity on responses to cholesterol-lowering drug therapy leading to rational dose adjustment of cholesterol-lowering drugs for different people use.

Hypercholesteremia. --- Cholesteremia --- Cholesterolemia --- Hypercholesterolemia --- Hyperlipidemia --- Blood cholesterol --- Medicine --- Cardiology and Cardiovascular Medicine --- Cardiac Electrophysiology --- Health Sciences

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Over 25 million people in the U.S. alone have benefited from statins (such drugs as Lipitor, Zocor, Crestor, Pravachol) in preventing stroke, heart attack, and other forms of coronary heart disease. But how did these remarkable, life-saving drugs come into being? In Triumph of the Heart, Dr. Jie Jack Li, a medicinal chemist and expert on drug discovery, tells the fascinating story of statins. Drawn from interviews with many scientists involved in the discovery and development of these drugs, the book illuminates the human side of science by revealing the role played by persistence, luck, and sudden insight that characterise major discoveries.

Statins (Cardiovascular agents) --- Hydroxymethylglutaryl coenzyme A reductases --- Statin drugs --- Anticholesteremic agents --- Enzyme inhibitors --- History. --- Inhibitors --- Anticholesteremic agents. --- Anticholesterol drugs --- Antihypercholestermic agents --- Cholesterol inhibitors --- Cholesterol-lowering drugs --- Hypocholesteremic agents --- Antilipemic agents