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This Special Issue of Entropy, titled “Recent Advances in Single-Particle Tracking: Experiment and Analysis”, contains a collection of 13 papers concerning different aspects of single-particle tracking, a popular experimental technique that has deeply penetrated molecular biology and statistical and chemical physics. Presenting original research, yet written in an accessible style, this collection will be useful for both newcomers to the field and more experienced researchers looking for some reference. Several papers are written by authorities in the field, and the topics cover aspects of experimental setups, analytical methods of tracking data analysis, a machine learning approach to data and, finally, some more general issues related to diffusion.

diauxic growth --- replicator equation --- mesoscopic model --- integro-differential equations --- anomalous diffusion --- statistical analysis --- single-particle tracking --- trajectory classification --- fractional Brownian motion --- estimation --- autocovariance function --- neural network --- Monte Carlo simulations --- multifractional Brownian motion --- power of the statistical test --- machine learning classification --- feature engineering --- confinement --- information theory --- Brownian particle --- stochastic thermodynamics --- CTRW --- diffusing-diffusivity --- occupation time statistics --- wound healing dynamics --- single pseudo-particle tracking --- phase contrast image segmentation --- 3D single-particle tracking --- Fisher information --- non-uniform illumination --- SPT --- deep learning --- residual neural networks --- random walk --- heterogeneous --- endosomes --- single particle trajectory --- stochastic processes --- trapping

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The classical Melnikov method provides information on the behavior of deterministic planar systems that may exhibit transitions, i.e. escapes from and captures into preferred regions of phase space. This book develops a unified treatment of deterministic and stochastic systems that extends the applicability of the Melnikov method to physically realizable stochastic planar systems with additive, state-dependent, white, colored, or dichotomous noise. The extended Melnikov method yields the novel result that motions with transitions are chaotic regardless of whether the excitation is deterministic or stochastic. It explains the role in the occurrence of transitions of the characteristics of the system and its deterministic or stochastic excitation, and is a powerful modeling and identification tool. The book is designed primarily for readers interested in applications. The level of preparation required corresponds to the equivalent of a first-year graduate course in applied mathematics. No previous exposure to dynamical systems theory or the theory of stochastic processes is required. The theoretical prerequisites and developments are presented in the first part of the book. The second part of the book is devoted to applications, ranging from physics to mechanical engineering, naval architecture, oceanography, nonlinear control, stochastic resonance, and neurophysiology.

Differentiable dynamical systems. --- Chaotic behavior in systems. --- Stochastic systems. --- Systems, Stochastic --- Stochastic processes --- System analysis --- Chaos in systems --- Chaos theory --- Chaotic motion in systems --- Differentiable dynamical systems --- Dynamics --- Nonlinear theories --- System theory --- Differential dynamical systems --- Dynamical systems, Differentiable --- Dynamics, Differentiable --- Differential equations --- Global analysis (Mathematics) --- Topological dynamics --- Affine transformation. --- Amplitude. --- Arbitrarily large. --- Attractor. --- Autocovariance. --- Big O notation. --- Central limit theorem. --- Change of variables. --- Chaos theory. --- Coefficient of variation. --- Compound Probability. --- Computational problem. --- Control theory. --- Convolution. --- Coriolis force. --- Correlation coefficient. --- Covariance function. --- Cross-covariance. --- Cumulative distribution function. --- Cutoff frequency. --- Deformation (mechanics). --- Derivative. --- Deterministic system. --- Diagram (category theory). --- Diffeomorphism. --- Differential equation. --- Dirac delta function. --- Discriminant. --- Dissipation. --- Dissipative system. --- Dynamical system. --- Eigenvalues and eigenvectors. --- Equations of motion. --- Even and odd functions. --- Excitation (magnetic). --- Exponential decay. --- Extreme value theory. --- Flow velocity. --- Fluid dynamics. --- Forcing (recursion theory). --- Fourier series. --- Fourier transform. --- Fractal dimension. --- Frequency domain. --- Gaussian noise. --- Gaussian process. --- Harmonic analysis. --- Harmonic function. --- Heteroclinic orbit. --- Homeomorphism. --- Homoclinic orbit. --- Hyperbolic point. --- Inference. --- Initial condition. --- Instability. --- Integrable system. --- Invariant manifold. --- Iteration. --- Joint probability distribution. --- LTI system theory. --- Limit cycle. --- Linear differential equation. --- Logistic map. --- Marginal distribution. --- Moduli (physics). --- Multiplicative noise. --- Noise (electronics). --- Nonlinear control. --- Nonlinear system. --- Ornstein–Uhlenbeck process. --- Oscillation. --- Parameter space. --- Parameter. --- Partial differential equation. --- Perturbation function. --- Phase plane. --- Phase space. --- Poisson distribution. --- Probability density function. --- Probability distribution. --- Probability theory. --- Probability. --- Production–possibility frontier. --- Relative velocity. --- Scale factor. --- Shear stress. --- Spectral density. --- Spectral gap. --- Standard deviation. --- Stochastic process. --- Stochastic resonance. --- Stochastic. --- Stream function. --- Surface stress. --- Symbolic dynamics. --- The Signal and the Noise. --- Topological conjugacy. --- Transfer function. --- Variance. --- Vorticity.