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A classic nephrology reference for over 20 years, Seldin & Giebisch's The Kidney, is the acknowledged authority on renal physiology and pathophysiology. The fourth edition follows the changed focus of nephrology research to the study of how individual molecules work together to affect cellular and organ function, emphasizing the mechanisms of disease. With over 40 new chapters and over 1000 illustrations, this edition offers the most in-depth discussion anywhere of the physiologic and pathophysiologic processes of renal disease. Comprehensive, authoritative coverage progresses fr

Nieren. --- Fysiologie. --- Pathologische fysiologie. --- Kidney --- Kidney Diseases --- Water-Electrolyte Balance. --- Water-Electrolyte Imbalance. --- Kidneys --- Water-electrolyte imbalances --- Water-electrolyte balance (Physiology) --- Reins --- Troubles hydroélectrolytiques --- Equilibre hydroélectrolytique (Physiologie) --- physiology. --- physiopathology. --- Physiology. --- Diseases. --- Physiologie --- Maladies --- Electrolyte Balance --- Fluid Balance --- Balance, Electrolyte --- Balance, Fluid --- Balance, Water-Electrolyte --- Water Electrolyte Balance --- Electrolytes --- Osmotic Pressure --- Water-Electrolyte Imbalance --- Imbalance, Water-Electrolyte --- Imbalances, Water-Electrolyte --- Water Electrolyte Imbalance --- Water-Electrolyte Imbalances --- Water Intoxication --- Water-Electrolyte Balance --- Pathophysiology. --- Kidney diseases --- Nephritis --- Nephropathy --- Renal diseases --- physiology --- physiopathology

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Renin-angiotensin system. --- RA system --- RAA system --- RAAS (Physiology) --- RAS (Physiology) --- Renin-angiotensin-aldosterone axis --- Renin-angiotensin-aldosterone system --- Aldosterone --- Angiotensins --- Renin --- Water-electrolyte balance (Physiology) --- Blood pressure --- Regulation

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This revised and expanded second edition presents the most recent evidence-based facts on perioperative fluid management and discusses fluid management from basic sciences to clinical applications and the patients’ outcomes. Recent advances in understanding the Revised Starling principle with new concepts in tissue perfusion and the most recent techniques of perioperative goal directed fluid management are described. The endothelial glycocalyx functions and the influence of fluid management on its integrity are covered in detail; moreover, the techniques for its protection are also discussed. The dilemma of perioperative use of hydroxyethyl starch solutions and the resurgence of interest in using human albumin as an alternative colloid is explored. The problems of using unbuffered solutions during the perioperative period and comparison between restrictive versus liberal fluid management are discussed in full. Lastly, case scenarios for every possible clinical situation describe in full the most up-to-date fluid management for the corresponding clinical problem. Perioperative Fluid Management, Second Edition is of interest to anesthesiologists and also intensivists.

Anesthesiology. --- Critical care medicine. --- Intensive / Critical Care Medicine. --- Intensive care --- Intensive medicine --- Medicine --- Emergency medicine --- Intensive care units --- Anaesthesiology --- Surgery --- Fluid therapy. --- Fluid replacement therapy --- Fluids --- Therapeutics --- Water-electrolyte balance (Physiology) --- Therapeutic use

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How exciting it is to see a field so well established as the ren- angiotensin system continue to grow and mature. Originally, following the original identification of renin by Tigerstedt and Bergman over 100 years ago, workers in this area spent years attempting to establish its role in experimental and renal hypertension. The early work by Goldblatt, in 1934, demonstrated that the placement of a clip around a renal artery was clearly related to the subsequent development of hypertension. However, it wasn't until the simultaneous finding by two different geographically separated teams, Page, et al, in the United States and Braun-Menendez, et al, in Argentina that the peptide angiotensin was identified. Thus, the rate-limiting enzyme renin was released from the kidney and catalyzed a biochemical cascade which was eventually shown to produce the elevated arterial pressure. Subsequently, many workers contributed to the elucidation of the concept and sequence of angiotensin I1 generation. Thus, the enzyme renin acted upon its protein substrate, produced in the liver, to liberate the decapeptide angiotensin I which, upon circulating through the pulmonary circulation, finally produced the potent octapeptide angiotensin. Several important subsequent findings demonstrated that angiotensin I1 promoted the release of the adrenal corticosteroid from that gland, thereby resulting in a larger system, the renin-angiotensin-aldosterone system. Further, this system demonstrated a classical biofeedback and the circulating octapeptide was shown to have additional biological activities in organs other than heart, vessels, kidney, adrenals, and even brain.

Renin-angiotensin system. --- Heart --- Renal hypertension. --- Renin. --- Physiology. --- Aspartic proteinases --- Juxtaglomerular apparatus --- Renal parenchymatous hypertension --- Hypertension --- Kidneys --- RA system --- RAA system --- RAAS (Physiology) --- RAS (Physiology) --- Renin-angiotensin-aldosterone axis --- Renin-angiotensin-aldosterone system --- Aldosterone --- Angiotensins --- Renin --- Water-electrolyte balance (Physiology) --- Blood pressure --- Diseases --- Regulation --- Cardiology. --- Internal medicine

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Renin-angiotensin system --- Renin-Angiotensin System --- Periodicals. --- Système rénine-angiotensine --- Renin-angiotensin system. --- Chemistry --- Health Sciences --- Life Sciences --- Social Sciences --- Biochemistry --- General and Others --- Physiology --- Behavioral Science (Psychology) and Counselling --- renin-angiotensin-aldosterone system --- biomedicine --- Système rénine-angiotensine --- RA system --- RAA system --- RAAS (Physiology) --- RAS (Physiology) --- Renin-angiotensin-aldosterone axis --- Renin-angiotensin-aldosterone system --- Aldosterone --- Angiotensins --- Renin --- Water-electrolyte balance (Physiology) --- Blood pressure --- Regulation --- Human medicine