Listing 1 - 10 of 24 | << page >> |
Sort by
|
Choose an application
Completely revised and expanded, this second edition of The Cytokine FactsBook is the most up-to-date reference manual available for all current well-characterized interleukins, cytokines, and their receptors. An additional 52 cytokines are included, doubling the number of entries from the previous edition. The key properties of each cytokine are described and presented in a very accessible format with diagrams for each of the receptors. The Cytokine FactsBook includes free online access to the regularly updated Cytokine Webfacts. Cytokine Webfacts is a web-based comprehensive compendium of facts about cytokines and their receptors that includes a variety of data representations, such as text, signal pathway diagrams and 3D images. This exciting resource is integrated into other databases via hypertext links to provide a unique network, and contains a web-enabled version of RasMol for viewing structures.
Cytokines. --- Cytokines--Handbooks, manuals, etc. Cytokines--outlines. --- Receptors, Immunologic --- Intercellular Signaling Peptides and Proteins --- Proteins --- Receptors, Cell Surface --- Biological Factors --- Peptides --- Amino Acids, Peptides, and Proteins --- Membrane Proteins --- Chemicals and Drugs --- Cytokines --- Receptors, Cytokine --- Biology --- Health & Biological Sciences --- Microbiology & Immunology --- Cellular immunity --- Immune response --- Regulation --- Receptors, cytokine
Choose an application
Endometriosis --- Endometrium. --- Immunologic Factors --- Immunological aspects. --- Biological Response Modifiers --- Biomodulators --- Factors, Immunologic --- Immune Factors --- Immunological Factors --- Modifiers, Biological Response --- Response Modifiers, Biological --- Biological Response Modifier --- Biomodulator --- Immune Factor --- Immunological Factor --- Immunomodulator --- Immunomodulators --- Factor, Immune --- Factor, Immunological --- Factors, Immune --- Factors, Immunological --- Modifier, Biological Response --- Response Modifier, Biological --- Receptors, Immunologic --- Molecular Mechanisms of Pharmacological Action --- Endometria --- Adenomyosis --- Endometrium --- Generative organs, Female --- Pelvis --- Diseases --- Endometriosis.
Choose an application
The T Cell Receptor FactsBook contains entries on all the 176 functional variable, diversity, joining, and constant regions of the human T cell receptor, including alpha, beta, gamma, and delta loci. Introductory chapters summarize information of T cell receptor chain synthesis, chromosomal location, and an overview of the human T cell receptor loci.
T cells. --- T cells Receptors--Handbooks, manuals, etc. T-cell receptor genes--Handbooks, manuals, etc. --- T-cell receptor genes. --- Receptors, Antigen, T-Cell --- Genes, T-Cell Receptor --- Genes --- Receptors, Antigen --- Genome Components --- Receptors, Immunologic --- Receptors, Cell Surface --- Genome --- Membrane Proteins --- Genetic Structures --- Proteins --- Genetic Phenomena --- Amino Acids, Peptides, and Proteins --- Phenomena and Processes --- Chemicals and Drugs --- Microbiology & Immunology --- Biology --- Health & Biological Sciences --- T cells --- T-cell receptor genes --- Receptors --- T lymphocytes --- Thymus-dependent cells --- Thymus-dependent lymphocytes --- Thymus-derived cells --- Lymphocytes
Choose an application
therapeutics --- pharmacology --- antibodies --- Immunoglobulins --- Antibodies --- Immunologic Factors. --- Therapeutic use. --- therapeutic use. --- Biological Response Modifiers --- Biomodulators --- Factors, Immunologic --- Immune Factors --- Immunological Factors --- Modifiers, Biological Response --- Response Modifiers, Biological --- Immunomodulators --- Factors, Immune --- Factors, Immunological --- Receptors, Immunologic --- Molecular Mechanisms of Pharmacological Action --- Immune globulins --- Immune serum globulin --- Blood proteins --- Globulins --- Plasma cells --- Antibody diversity --- Antigens --- Bacterial immunoglobulin-binding proteins --- Biological Response Modifier --- Biomodulator --- Immune Factor --- Immunological Factor --- Immunomodulator --- Factor, Immune --- Factor, Immunological --- Modifier, Biological Response --- Response Modifier, Biological
Choose an application
Chemokine Receptors in Cancer summarizes the growing body of evidence that several chemokine receptors contribute to tumor behavior. Chemokine receptors were first identified on leukocytes and mediate directed migration of many host cells to sites of ligand expression. It is now well established that most malignant cells also express one or more chemokine receptor. This book describes our current understanding regarding how chemokine receptors contribute to tumor cell migration as well as cell survival and proliferation. The function of chemokine receptors expressed on host cells including antitumor immune effector cells as well as angiostatic and angiogeneic functions of chemokines acting on endothelial cells are described. The role of chemokine receptors that act as decoy receptors is also summarized. The therapeutic potential and challenges of targeting chemokine receptors or cognate ligands is also addressed.
Cancer cells --- Chemokines --- Receptors, Cytokine --- Antigens, CD --- Receptors, G-Protein-Coupled --- Diseases --- Angiogenesis Modulating Agents --- Growth Substances --- Receptors, Immunologic --- Antigens, Differentiation --- Receptors, Cell Surface --- Membrane Proteins --- Biological Markers --- Antigens, Surface --- Physiological Effects of Drugs --- Pharmacologic Actions --- Proteins --- Antigens --- Biological Factors --- Amino Acids, Peptides, and Proteins --- Chemicals and Drugs --- Chemical Actions and Uses --- Angiogenesis Inducing Agents --- Neoplasms --- Receptors, Chemokine --- Biology --- Health & Biological Sciences --- Medicine --- Pharmacy, Therapeutics, & Pharmacology --- Oncology --- Microbiology & Immunology --- Growth --- Regulation. --- Receptors --- Effect of drugs on. --- Effect of drugs on --- Regulation --- Chemokines. --- Drug receptors. --- Drugs --- Receptors, Drug --- Chemotactic cytokines --- Inflammatory peptides --- Intercrines --- Medicine. --- Cancer research. --- Oncology. --- Biomedicine. --- Cancer Research. --- Cell receptors --- Cytokines --- Inflammation --- Peptides --- Mediators --- Oncology . --- Tumors --- Cancer research
Choose an application
Tumor necrosis factor (TNF) superfamily is a rapidly growing family of cytokines that interacts with a corresponding superfamily of receptors. Ligand-receptor interactions of this superfamily are involved in numerous biological processes ranging from hematopoiesis to pleiotropic cellular responses, including activation, proliferation, differentiation, and apoptosis. The particular response depends on the receptor the cell type, and the concurrent signals received by the cell. Worldwide interest in the TNF field surged dramatically early in 1984 with the cloning and defining of the profound cellular effects of the first member of this family, TNFa. Subsequently, the major influence of TNFa on the development and functioning of the immune system was established. Today, over 20 human TNF ligands and their more than 30 corresponding receptors have been identified. Few receptors still remain orphans. What has emerged over the years is that most TNF ligands bind to one distinct receptor and some of the TNF ligands are able to bind to multiple TNF receptors, explaining to some extent the apparent disparity in the number of TNF receptors and ligands. Yet, in spite of some redundancy in TNF ligand/receptor interactions, it is clear that in vivo spatial, temporal, and indeed cell- and tissue-specific expression of both ligands and their receptors are important factors in determining the precise nature of cellular physiological and pathological processes they control. Therapeutic Targets of the TNF Superfamily presents the state-of-the art account on the role of TNF superfamily members in the pathogenesis and their use in current intervention of cancers and autoimmune disease. This text will be highly valuable for investigators to understand the disease processes regulated by TNF superfamily members and to develop effective therapeutics. A view into the future, inspired by the comprehensive work presented in this volume, predicts that researchers studying TNF superfamily members will continue to make rapid progress in identifying relevant components to the disease process and new therapeutic strategies to target many human diseases including cancers, autoimmune disease and others.
Tumor necrosis factor --Agonists --Therapeutic use. --- Tumor necrosis factor. --- Tumor necrosis factor --- Autoimmune Diseases --- Tumor Necrosis Factors --- Receptors, Tumor Necrosis Factor --- Neoplasms --- Inflammation --- Drug Therapy --- Immune System Diseases --- Diseases --- Intercellular Signaling Peptides and Proteins --- Pathologic Processes --- Cytokines --- Receptors, Cytokine --- Therapeutics --- Pathological Conditions, Signs and Symptoms --- Peptides --- Biological Factors --- Proteins --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Receptors, Immunologic --- Amino Acids, Peptides, and Proteins --- Chemicals and Drugs --- Receptors, Cell Surface --- Membrane Proteins --- Microbiology & Immunology --- Biology --- Health & Biological Sciences --- Agonists --- Therapeutic use --- Therapeutic use. --- Cachectin --- Lymphotoxin --- TNF (Immunology) --- Medicine. --- Immunology. --- Biomedicine. --- Biomedicine general. --- Immunobiology --- Life sciences --- Serology --- Clinical sciences --- Medical profession --- Human biology --- Medical sciences --- Pathology --- Physicians --- Glycoproteins --- Growth factors --- Macrophages --- Biomedicine, general. --- Health Workforce
Choose an application
Allergy and Immunology --- Immunotherapy, Active --- HLA-D Antigens --- Immunologic Techniques --- Immunologic Tests --- Receptors, Immunologic --- Immunodiagnosis --- Diagnostics immunologiques --- Periodicals. --- Périodiques --- Immunodiagnosis. --- Allergy and Immunology. --- Immunotherapy, Active. --- HLA-D Antigens. --- Immunologic Techniques. --- Immunologic Tests. --- Receptors, Immunologic. --- Science --- Immunologic Receptor --- Immunological Receptors --- Immunologic Receptors --- Receptor, Immunologic --- Receptors, Immunological --- Diagnosis, Immunologic --- Immunologic Diagnosis --- Immunologic Test --- Immunological Tests --- Tests, Immunologic --- Diagnosis, Immunological --- Diagnoses, Immunologic --- Diagnoses, Immunological --- Immunodiagnoses --- Immunologic Diagnoses --- Immunological Diagnoses --- Immunological Diagnosis --- Immunological Test --- Test, Immunologic --- Test, Immunological --- Tests, Immunological --- Antibody Dissociation --- Immunologic Technic --- Immunologic Technics --- Immunologic Technique --- Immunological Technics --- Immunological Techniques --- Technic, Immunologic --- Technics, Immunologic --- Technique, Immunologic --- Techniques, Immunologic --- Antibody Dissociations --- Dissociation, Antibody --- Dissociations, Antibody --- Immunological Technic --- Immunological Technique --- Technic, Immunological --- Technics, Immunological --- Technique, Immunological --- Techniques, Immunological --- HLA-D --- HLA-Dw --- Immune Response Associated Antigens, Human --- Antigens, HLA-D --- Class II Human Antigens --- HLA-Dw Antigens --- Human Class II Antigens --- Ia-Like Antigens, Human --- Immune Response-Associated Antigens, Human --- Immune-Associated Antigens, Human --- Immune-Response Antigens, Human --- Antigens, HLA D --- Antigens, HLA-Dw --- Antigens, Human Ia-Like --- Antigens, Human Immune-Associated --- Antigens, Human Immune-Response --- HLA D Antigens --- HLA Dw Antigens --- Human Ia-Like Antigens --- Human Immune-Associated Antigens --- Human Immune-Response Antigens --- Ia Like Antigens, Human --- Immune Associated Antigens, Human --- Immune Response Antigens, Human --- Active Immunotherapy --- Therapy, Vaccine --- Immune RNA Manipulation --- Vaccine Therapy --- Active Immunotherapies --- Immune RNA Manipulations --- Immunotherapies, Active --- Manipulation, Immune RNA --- Manipulations, Immune RNA --- RNA Manipulation, Immune --- RNA Manipulations, Immune --- Therapies, Vaccine --- Vaccine Therapies --- Allergy Specialty --- Allergy, Immunology --- Immunology and Allergy --- Immunology, Allergy --- Immunology --- Specialty, Allergy --- Immunological diagnosis --- methods --- Immunity --- Immunochemistry --- Clinical immunology --- Diagnosis, Laboratory --- Immunoassay
Choose an application
Immunodiagnosis --- Allergy and Immunology. --- HLA-D Antigens. --- Immunologic Techniques. --- Immunologic Tests. --- Receptors, Immunologic. --- Diagnostics immunologiques --- Immunodiagnosis. --- Immunological diagnosis --- Immunologic Receptor --- Immunological Receptors --- Immunologic Receptors --- Receptor, Immunologic --- Receptors, Immunological --- Diagnosis, Immunologic --- Immunologic Diagnosis --- Immunologic Test --- Immunological Tests --- Tests, Immunologic --- Diagnosis, Immunological --- Diagnoses, Immunologic --- Diagnoses, Immunological --- Immunodiagnoses --- Immunologic Diagnoses --- Immunological Diagnoses --- Immunological Diagnosis --- Immunological Test --- Test, Immunologic --- Test, Immunological --- Tests, Immunological --- Antibody Dissociation --- Immunologic Technic --- Immunologic Technics --- Immunologic Technique --- Immunological Technics --- Immunological Techniques --- Technic, Immunologic --- Technics, Immunologic --- Technique, Immunologic --- Techniques, Immunologic --- Antibody Dissociations --- Dissociation, Antibody --- Dissociations, Antibody --- Immunological Technic --- Immunological Technique --- Technic, Immunological --- Technics, Immunological --- Technique, Immunological --- Techniques, Immunological --- Allergy and Immunology --- HLA-D --- HLA-Dw --- Immune Response Associated Antigens, Human --- Antigens, HLA-D --- Class II Human Antigens --- HLA-Dw Antigens --- Human Class II Antigens --- Ia-Like Antigens, Human --- Immune Response-Associated Antigens, Human --- Immune-Associated Antigens, Human --- Immune-Response Antigens, Human --- Antigens, HLA D --- Antigens, HLA-Dw --- Antigens, Human Ia-Like --- Antigens, Human Immune-Associated --- Antigens, Human Immune-Response --- HLA D Antigens --- HLA Dw Antigens --- Human Ia-Like Antigens --- Human Immune-Associated Antigens --- Human Immune-Response Antigens --- Ia Like Antigens, Human --- Immune Associated Antigens, Human --- Immune Response Antigens, Human --- Allergy Specialty --- Allergy, Immunology --- Immunology and Allergy --- Immunology, Allergy --- Immunology --- Specialty, Allergy --- methods --- HLA-D Antigens --- Immunologic Techniques --- Immunologic Tests --- Receptors, Immunologic --- Immunity --- Immunochemistry --- Clinical immunology --- Diagnosis, Laboratory --- Immunoassay --- Journal --- Periodicals --- HLA-D Antigens.. --- HLA histocompatibility antigens. --- Antigènes HLA-D. --- Diagnostics immunologiques. --- HL-A histocompatibility antigens --- HLA antigens --- HLA transplantation antigens --- Human leukocyte antigens --- Transplantation antigens, Human --- Histocompatibility antigens --- Major histocompatibility complex
Choose an application
Cell death, or apoptosis, plays an important role in biological processes and disease and offers special opportunities to develop new therapies for cancer, autoimmune disease, stroke, heart attack, and Alzheimer's disease. In Death Receptors in Cancer Therapy, leading physician-scientists and basic researchers review in depth our latest understanding of the molecular events that regulate cell death, illuminating those molecules that provide targets for agonists or antagonists designed to modulate death signaling for therapeutic purposes. The authors focus on the extrinsic system of death receptors, their regulation and function, and their abnormalities in cancer. Topics of particlar interest include resistance to apoptosis, TRAIL signaling, death receptors in embryonic development, mechanisms of caspase activation, and death receptor mutations in cancer. Additional chapters address death signaling in melanoma, synthetic retinoids and death receptors, the role of p53 in death receptor regulation, immune suppression of cancer, and combination therapy with death ligands. Authoritative and up-to-date, Death Receptors in Cancer Therapy offers a timely compendium of cell death signaling pathways for those seeking either a basic understanding of apoptosis or the knowledge needed to develop new therapeutics that will activate or block death signaling in disease.
Neoplasms --- Cell Death --- Gene Therapy --- Receptors, Tumor Necrosis Factor --- Apoptosis --- Cell receptors --- Cancer --- Cellular signal transduction --- Apoptose --- Récepteurs cellulaires --- Transduction du signal cellulaire --- immunology --- therapy --- methods --- Molecular aspects --- Aspect moléculaire --- Kanker --- Kanker ; moleculaire aspecten --- Apoptosis. --- Cancer -- Molecular aspects. --- Cell receptors. --- Cellular signal transduction. --- Biological Therapy --- Genetic Engineering --- Diseases --- Investigative Techniques --- Cell Physiological Processes --- Receptors, Cytokine --- Cell Physiological Phenomena --- Receptors, Immunologic --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Genetic Techniques --- Therapeutics --- Receptors, Cell Surface --- Phenomena and Processes --- Membrane Proteins --- Proteins --- Amino Acids, Peptides, and Proteins --- Chemicals and Drugs --- Methods --- Medicine --- Biology --- Health & Biological Sciences --- Cytology --- Oncology --- Molecular aspects. --- Cellular information transduction --- Information transduction, Cellular --- Signal transduction, Cellular --- Cell membrane receptors --- Cell surface receptors --- Receptors, Cell --- Medicine. --- Oncology. --- Medicine & Public Health. --- Tumors --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Bioenergetics --- Cellular control mechanisms --- Information theory in biology --- Binding sites (Biochemistry) --- Cell membranes --- Cell death
Choose an application
Immunity --- Immunity. --- Immunologic Factors. --- Immune System Diseases. --- Diseases of Immune System --- Immune Diseases --- Immunological Diseases --- Immune Disorders --- Immunologic Diseases --- Disease, Immune --- Disease, Immune System --- Disease, Immunologic --- Disease, Immunological --- Diseases, Immune --- Diseases, Immune System --- Diseases, Immunologic --- Diseases, Immunological --- Disorder, Immune --- Disorders, Immune --- Immune Disease --- Immune Disorder --- Immune System Disease --- Immunologic Disease --- Immunological Disease --- Biological Response Modifiers --- Biomodulators --- Factors, Immunologic --- Immune Factors --- Immunological Factors --- Modifiers, Biological Response --- Response Modifiers, Biological --- Immunomodulators --- Factors, Immune --- Factors, Immunological --- Immunologic Factors --- Immune System Diseases --- Immunotherapy --- Immunotherapies --- Disease --- immunology --- Immunology --- Immunity, Active --- Immunologic Techniques --- Receptors, Immunologic --- Molecular Mechanisms of Pharmacological Action --- Immunoglobulins --- Immunotherapy. --- Immune System Disorders --- Disorder, Immune System --- Immune System Disorder --- Biological Response Modifier --- Biomodulator --- Immune Factor --- Immunological Factor --- Immunomodulator --- Factor, Immune --- Factor, Immunological --- Modifier, Biological Response --- Response Modifier, Biological --- Immune Process --- Immune Response --- Immune Processes --- Immune Responses --- Process, Immune --- Response, Immune --- Combined Antibody Therapeutics
Listing 1 - 10 of 24 | << page >> |
Sort by
|