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Radiotherapy --- Neoplasms --- Radiation Oncology. --- radiotherapy.

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Cancer --- Radiotherapy --- Radiation Oncology. --- Neoplasms --- Radiotherapy. --- radiotherapy.

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This book brings together the expertise of nationally renowned radiologists and pathologists in resolving difficult breast lesions detected on imaging. While there are several separate resources available for radiology residents to study imaging modalities, there are few if any books that illustrate simultaneous radiology pathology correlates. This text will be a useful reference for residents, fellows, and practicing attendings in both disciplines. As the two disciplines of radiology and pathology are interrelated, the scope of the book is to provide and inform readers of not only typical examples of breast lesions that correlate with imaging findings that may or may not require surgical excision but also to resolve problematic lesions that are discordant with imaging findings. This book contains 14 chapters containing hundreds of images supplemented with key references. These chapters include outlines with systematic approaches to each disease entity punctuated by various imaging techniques, key diagnostic points seen on imaging, and pathology followed by differential diagnostic considerations. Finally, a summary of concordant and discordant findings is provided at the end of each section. Written by experts in the fields of radiology and pathology, as well as surgical colleagues that manage patients with breast diseases, Radiology Pathology Correlations of Breast Lesions serves as an easy-to-use reference for radiology and pathology residents and fellows, as well as practicing pathologists and radiologists. This book integrates the radiologic and pathologic appearance of relatively common breast lesions side-by-side with easy-to-understand descriptions and illustrations.

Pathology. --- Medical radiology. --- Oncology. --- Radiation Oncology.

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The mode of action by radiation is postulated to be the production of double strand breaks of DNA. The repair of double strand breaks occurs through non homologous end joining through acetylation of histone proteins by histone acetyltransferases (HATs). The fixation of double strand breaks through HAT inhibitors is a promising application for radiation sensitization in the clinic. P53 is a tumour suppressor gene and its mutation has been implicated in 60% of human cancers. As one of the pivotal anticancer genes, P53 controls the transcription and translation of a series of genes. The kinetics of DNA double strand break generation and their co relation to P53 status, ATM and ARF activation are computed and modelled for understanding the potential of such research.

Radiation Oncology. --- Oncology, Radiation --- Radiology, Therapeutic --- Therapeutic Radiology --- Radiotherapy

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This book offers a detailed guide to MR-Linac, a unique and fast growing radiation treatment modality. MR-linac is new technology that is a fusion of an MRI and a linear accelerator on the same gantry. It can change both target volume delineation and tumor visualization in real time using MR-cine images and treatment. Tumor location changes moment to moment as radiation is delivered, but this cannot be visualized in current radiation therapy practices. This new and rapidly growing technology can provide adaptive therapy that was not possible before. This book presents current knowledge on MR-linac technology, clinical practices, and ultimately patient outcome where dose escalation is not possible due to limiting normal tissue structures in the vicinity of tumor. There are two commercial MR-linac machines under consideration and both will be covered in detail. The book is divided into four sections. The first gives a general introduction to MR-Linac, covering the role of MRI in radiation oncology, the clinical necessity of this technology, and patient selection. The next section details the physics and technology of MR-Linac, covering image sequence, motion management, and treatment planning. Section three offers the clinical applications of MR-Linac and is divided by body area, including lung, prostate, and breast. Finally, the fourth section looks to the future and what this technology can mean for radiation oncology. This is an ideal guide for radiation oncologists, medical physicists, and relevant trainees. .

Medical radiology. --- Oncology. --- Radiology. --- Radiation Oncology. --- Cancer --- Radiation --- Radiotherapy.