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The pituitary, albeit a small gland, is known as the ""master gland"" of the endocrine system and contributes to a wide spectrum of disorders, diseases, and syndromes. Since the publication of the second edition of The Pituitary, in 2002, there have been major advances in the molecular biology research of pituitary hormone production and action and there is now a better understanding of the pathogenesis of pituitary tumors and clinical syndromes resulting in perturbation of pituitary function. There have also been major advances in the clinical management of pituitary disorders. Medical res
Pituitary gland --- Diseases. --- Pathophysiology. --- Physiology. --- Pituitary Diseases --- Pituitary Gland --- Pituitary Hormones, Anterior
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The Pituitary, Fourth Edition, continues the tradition of a cogent blend of basic science and clinical medicine which has been the successful hallmark of prior editions. This comprehensive text is devoted to the pathogenesis, diagnosis, and treatment of pituitary disorders. The new edition has been extensively revised to reflect new knowledge derived from advances in molecular and cell biology, biochemistry, diagnostics, and therapeutics as they apply to the pituitary gland. The wide spectrum of clinical disorders emanating from dysfunction of the master gland is described in detail by experts in the field. Fundamental mechanisms underlying disease pathogenesis are presented to provide the reader with an in-depth understanding of mechanisms subserving both normal and disordered pituitary hormone secretion and action. This extensive body of knowledge is useful for students, trainees, physicians, and scientists who need to understand critical pituitary functions and how to care for patients with pituitary disorders. Chapters provide medical students, clinical and basic endocrinology trainees, endocrinologists, internists, pediatricians, gynecologists, and neurosurgeons with a comprehensive, yet integrated, text devoted to the science and art of pituitary medicine. Brings together pituitary experts from all areas of research and practice who take readers all the way from bench research, to genomic and proteomic analysis, clinical analysis, and new therapeutic approaches to pituitary disordersSaves researchers and clinicians time in quickly accessing the very latest details on a broad range of issues related to normal and diseased pituitary functionProvides a common language for endocrinologists, neurosurgeons, OB/GYNs, and endocrine researchers to discuss how the pituitary gland and hormones affect each major organ system.
Pituitary gland --- Pituitary Diseases --- Pituitary Gland --- Pituitary Hormones, Anterior --- Diseases. --- Pathophysiology. --- Physiology. --- physiopathology. --- diagnosis. --- physiology. --- Hypophysis cerebri --- Pituitary body --- Brain --- Endocrine glands --- Hypothalamo-hypophyseal system
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It is clear that the melanocortins are of immense academic interest. Further, these molecules have remarkable potential as pharmaceutical agents for treatment of multiple human and veterinary disorders and diseases. The evidence to support academic interest and clinical applications lies in significant part within the chapters of this book, chapters written by noted experts in the field who have worked diligently to understand the molecules and to move them toward clinical applications. I personally believe that the - MSH molecule and its derivatives will be used as routine therapeutics in the very near future. My belief is so strong that I left academia to form a company based on -MSH analogs and have caused millions of dollars to be spent on melanocortin research. Now why would a sane professor pick up such a challenge and enter business, an essential step toward any clinical application? It is the - MSH story that drove me. Consider that - MSH occurs in exactly the same amino acid sequence in humans and in the sea lamprey, an organism unchanged since its appearance during the Pennsylvanian period of the Paleozoic era (about 300 million years ago—way before dinosaurs were to be considered). There is unpublished evidence that the stability of the molecule can be traced back a half billion years. Frankly, I believe that the molecule existed even when single cells began to live together.
MSH (Hormone). --- MSH (Hormone) --- Pro-Opiomelanocortin --- Receptors, Corticotropin --- Biological Science Disciplines --- Metabolic Phenomena --- Receptors, G-Protein-Coupled --- Receptors, Neuropeptide --- Hypothalamic Hormones --- Receptors, Pituitary Hormone --- Natural Science Disciplines --- Pituitary Hormones, Anterior --- Receptors, Cell Surface --- Phenomena and Processes --- Neuropeptides --- Receptors, Neurotransmitter --- Receptors, Peptide --- Disciplines and Occupations --- Pituitary Hormones --- Membrane Proteins --- Peptide Hormones --- Nerve Tissue Proteins --- Proteins --- Hormones --- Peptides --- Amino Acids, Peptides, and Proteins --- Hormones, Hormone Substitutes, and Hormone Antagonists --- Receptors, Melanocortin --- Melanocortins --- Metabolism --- Physiology --- Chemicals and Drugs --- Human Anatomy & Physiology --- Health & Biological Sciences --- Animal Biochemistry --- Intermedin --- Melanocortin --- Melanocyte stimulating hormone --- Melanotropin --- Medicine. --- Biomedicine. --- Biomedicine general. --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Peptide hormones --- Proopiomelanocortin --- Health Workforce --- Biomedicine, general.
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She examines the decision-making processes at Monsanto that led to their making the drug available and discusses corporate, academic, and regulatory decision-making in the context of a restructured global political economy for agriculture. Mills shows that there was consensus about the scientific evidence but interpretation of that evidence differed depending on the context from which it was viewed. Scientists who analysed it for regulatory bodies interpreted it differently than scientists in corporate or academic institutions, and scientists in Canada and Europe interpreted it differently than those in the United States. In the United States it was assumed that any problems arising from its use could be taken care of within the existing dairy system; in Canada and Europe these problems were regarded as legitimate animal welfare issues. While all regulatory bodies agreed that human health problems were unlikely, in Canada the Health Protection Branch questioned this, but ultimately rejected the drug on animal health grounds.
SCIENCE --- Philosophy & Social Aspects --- Recombinant bovine somatotropin --- Health Policy --- Food Contamination --- Milk --- Growth Hormone --- Cattle --- Dairying --- Recombinant Proteins --- Proteins --- Agriculture --- Pituitary Hormones, Anterior --- Public Policy --- Ruminants --- Beverages --- Dairy Products --- Environmental Pollution --- Food Safety --- Bodily Secretions --- Amino Acids, Peptides, and Proteins --- Social Control Policies --- Food and Beverages --- Public Health --- Technology, Industry, and Agriculture --- Artiodactyla --- Fluids and Secretions --- Food --- Pituitary Hormones --- Peptide Hormones --- Chemicals and Drugs --- Mammals --- Environment and Public Health --- Policy --- Social Control, Formal --- Technology, Industry, Agriculture --- Anatomy --- Health Care --- Sociology --- Social Sciences --- Peptides --- Vertebrates --- Health Care Economics and Organizations --- Hormones --- Anthropology, Education, Sociology and Social Phenomena --- Hormones, Hormone Substitutes, and Hormone Antagonists --- Chordata --- Animals --- Eukaryota --- Organisms --- Veterinary Medicine --- Animal Sciences --- Health & Biological Sciences --- Earth & Environmental Sciences --- Eucarya --- Eukarya --- Eukaryotes --- Eukaryotas --- Eukaryote --- Animalia --- Animal --- Metazoa --- Chordates --- Chordate --- Hormones, Substitutes, Antagonists --- Endocrine Disruptors --- Hormone --- Hormone Receptor Agonists --- Agonists, Hormone Receptor --- Receptor Agonists, Hormone --- Endocrine Glands --- Healthcare Economics and Organizations --- Health Care Economics --- Health Economics --- Healthcare Economics --- Care Economic, Health --- Economic, Health --- Economic, Health Care --- Economic, Healthcare --- Economics, Health Care --- Health Care Economic --- Health Economic --- Healthcare Economic --- Vertebrate --- Peptide --- Polypeptide --- Polypeptides --- Science, Social --- Sciences, Social --- Social Science --- General Social Development and Population --- Community-Based Distribution --- Contraceptive Distribution --- Delivery of Healthcare --- Dental Care Delivery --- Distribution, Non-Clinical --- Distribution, Nonclinical --- Distributional Activities --- Healthcare --- Healthcare Delivery --- Healthcare Systems --- Non-Clinical Distribution --- Nonclinical Distribution --- Delivery of Dental Care --- Health Care Delivery --- Health Care Systems --- Activities, Distributional --- Activity, Distributional --- Care, Health --- Community Based Distribution --- Community-Based Distributions --- Contraceptive Distributions --- Deliveries, Healthcare --- Delivery, Dental Care --- Delivery, Health Care --- Delivery, Healthcare --- Distribution, Community-Based --- Distribution, Contraceptive --- Distribution, Non Clinical --- Distributional Activity --- Distributions, Community-Based --- Distributions, Contraceptive --- Distributions, Non-Clinical --- Distributions, Nonclinical --- Health Care System --- Healthcare Deliveries --- Healthcare System --- Non Clinical Distribution --- Non-Clinical Distributions --- Nonclinical Distributions --- System, Health Care --- System, Healthcare --- Systems, Health Care --- Systems, Healthcare --- Anatomies --- Regulation --- Social Control --- Control, Social --- Controls, Social --- Formal Social Control --- Formal Social Controls --- Regulations --- Social Controls --- Policies --- Mammalia --- Mammal --- Hormones, Peptide --- Peptide Hormone --- Polypeptide Hormone --- Polypeptide Hormones --- Hormone, Peptide --- Hormone, Polypeptide --- Hormones, Polypeptide --- Intercellular Signaling Peptides and Proteins --- Hormones, Pituitary --- Foods --- Nutritional Physiological Phenomena --- Nutritional Requirements --- Secretions and Fluids --- Hippopotamus --- Peccary --- Peccaries --- Community Health --- Environment, Preventive Medicine & Public Health --- Environment, Preventive Medicine and Public Health --- Health, Community --- Health, Public --- Preventive Medicine --- Education, Public Health Professional --- Food And Beverage --- And Beverage, Food --- And Beverages, Food --- Beverage, Food And --- Beverages and Food --- Beverages, Food And --- Cow Milk --- Cow's Milk --- Milk, Cow --- Milk, Cow's --- Infant Nutritional Physiological Phenomena --- Lactation --- Control Policies, Social --- Control Policy, Social --- Policies, Social Control --- Policy, Social Control --- Social Control Policy --- Secretions --- Bodily Secretion --- Secretion --- Secretion, Bodily --- Secretions, Bodily --- Safety, Food --- Dietary Exposure --- Hazard Analysis and Critical Control Points --- Pollution, Environmental --- Soil Pollution --- Pollution, Soil --- Environmental Pollutants --- Dairy Product --- Product, Dairy --- Products, Dairy --- Beverage --- Oreamnos americanus --- Goats, Mountain --- Ruminantia --- Goat, Mountain --- Mountain Goat --- Mountain Goats --- Ruminant --- Affirmative Action --- Migration Policy --- Population Policy --- Social Protection --- Social Policy --- Action, Affirmative --- Migration Policies --- Policies, Migration --- Policies, Population --- Policies, Public --- Policies, Social --- Policy, Migration --- Policy, Population --- Policy, Public --- Policy, Social --- Population Policies --- Protection, Social --- Public Policies --- Social Policies --- Policy Making --- Adenohypophyseal Hormones --- Anterior Pituitary Hormones --- Hormones, Adenohypophyseal --- Hormones, Anterior Pituitary --- Agricultural Development --- Farming --- Development, Agricultural --- Agricultural Inoculants --- Gene Products, Protein --- Gene Proteins --- Protein --- Protein Gene Products --- Proteins, Gene --- Molecular Mechanisms of Pharmacological Action --- Proteins, Biosynthetic --- Proteins, Recombinant DNA --- Biosynthetic Protein --- Biosynthetic Proteins --- DNA Recombinant Proteins --- Recombinant Protein --- DNA Proteins, Recombinant --- Protein, Biosynthetic --- Protein, Recombinant --- Proteins, DNA Recombinant --- Proteins, Recombinant --- Recombinant DNA Proteins --- Recombinant Proteins, DNA --- Biotechnology --- Bioreactors --- Dairy Industry --- Dairy Industries --- Industries, Dairy --- Industry, Dairy --- Beef Cow --- Bos grunniens --- Bos indicus --- Bos taurus --- Cow --- Cow, Domestic --- Dairy Cow --- Holstein Cow --- Yak --- Zebu --- Beef Cows --- Cow, Beef --- Cow, Dairy --- Cow, Holstein --- Cows --- Dairy Cows --- Domestic Cow --- Domestic Cows --- Yaks --- Zebus --- Growth Hormone, Pituitary --- Growth Hormones Pituitary, Recombinant --- Pituitary Growth Hormones, Recombinant --- Recombinant Growth Hormones --- Recombinant Pituitary Growth Hormones --- Recombinant Somatotropins --- Somatotropins, Recombinant --- Growth Hormone, Recombinant --- Pituitary Growth Hormone --- Recombinant Growth Hormone --- Somatotropin --- Somatotropin, Recombinant --- Growth Hormones, Recombinant --- Recombinant Somatotropin --- Bovine somatotropin --- Genetically engineered bovine somatotropin --- rBGH (Hormone) --- Recombinant bovine growth hormone --- Recombinant proteins --- Food Adulteration --- Adulteration, Food --- Adulterations, Food --- Contamination, Food --- Contaminations, Food --- Food Adulterations --- Food Contaminations --- Healthcare Policy --- National Health Policy --- Health Policies --- Health Policy, National --- Healthcare Policies --- National Health Policies --- Policy, Health --- Policy, Healthcare --- Policy, National Health --- Government policy --- Economic aspects --- Genetic engineering --- Agronomy --- Agronomies --- Health Care Policies --- Care Policies, Health --- Health Care Policy --- Policies, Health --- Policies, Health Care --- Policies, Healthcare --- Policy, Health Care --- Monsanto Company.
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