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Neural Crest Cells: Evolution, Development and Disease summarizes discoveries of historical significance and provides in-depth, current analyses of the evolution of neural crest cells, their contribution to embryo development, and their roles in disease. In addition, prospects for tissue engineering, repair and regeneration are covered, offering a timely synthesis of the current knowledge in neural crest cell research. A comprehensive resource on neural crest cells for researchers studying cell biology, developmental biology, stem cells and neurobiology, Neural Crest Cells: Evolut

Neural crest. --- Crest, Neural --- Ganglionic crest --- Ganglionic ridge --- Embryology --- Nervous system --- Neurons.

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The evolution of the neural crest sheds light on many of the oldest unanswered questions in developmental biology, including the role of germ layers in early embryogenesis, the development of the nervous system, how the vertebrate head arose developmentally and evolutionarily, and how growth factors and Hox genes direct cell differentiation and embryonic patterning. In this new edition of his essential work, The Neural Crest in Development and Evolution, Brian Hall has provided an up-to-date technically and intellectually rigorous synthesis of knowledge of all aspects of the neural crest and of neural crest cells (NCCs). These ten chapters are organized into three parts: (I) The discovery, and developmental and evolutionary origins of the neural crest; (II) cellular and tissue derivatives of the neural crest; (III) and tumors and birth defects arising from abnormal NCCs. The genetic and cellular bases for the identification of NCCs as early as during gastrulation, for induction of the neural crest, NCC delamination, migration and differentiation — understanding of all of which has increased enormously over the past decade — are discussed in depth in Part I. The evolutionary origin(s) of the neural crest is examined through an analysis of fossils, and of cell types, genes and gene networks in extant cephalochordates (amphioxus) and in ascidians. Four chapters grouped as Part II examine all aspects of neural crest-derived pigment cells, neurons, skeletal, cardiac and tooth-forming cells, with emphasis on how and when subpopulations of NCCs are specified and how their differentiation is controlled. The two chapters in Part III revisit NCC development in the context of tumors (neurocristopathies) and birth defects, with emphasis on genetic pathways, regulation of cell populations, and whether NCCs can be considered to be stem cells. About the Author: About the Author: Dr. Brian K. Hall has devoted much of his career to the study of the evolution and development of neural crest-derived skeletal tissues. He is a University Research Professor Emeritus at Dalhousie University in Halifax, Canada, a Visiting Distinguished Professor at Arizona State University in Tempe, a Fellow of the Royal Society of Canada, and a foreign fellow of the American Academy of Arts and Sciences. .

Neural Crest --embryology. --- Vertebrates --anatomy & histology. --- Vertebrates --Development. --- Vertebrates --Evolution. --- Neural crest --- Developmental neurobiology --- Neural Crest --- Crest, Neural --- Ganglionic crest --- Ganglionic ridge --- Life sciences. --- Human genetics. --- Cell biology. --- Developmental biology. --- Evolutionary biology. --- Neurobiology. --- Anthropology. --- Life Sciences. --- Developmental Biology. --- Evolutionary Biology. --- Cell Biology. --- Human Genetics. --- Neural crest. --- Development (Biology) --- Biology --- Growth --- Ontogeny --- Embryology --- Nervous system --- Evolution (Biology). --- Cytology. --- Animal evolution --- Animals --- Biological evolution --- Darwinism --- Evolutionary biology --- Evolutionary science --- Origin of species --- Evolution --- Biological fitness --- Homoplasy --- Natural selection --- Phylogeny --- Human beings --- Genetics --- Heredity, Human --- Human biology --- Physical anthropology --- Cell biology --- Cellular biology --- Cells --- Cytologists --- Neurosciences --- Primitive societies --- Social sciences

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(will follow).

Neural crest. --- Crest, Neural --- Ganglionic crest --- Ganglionic ridge --- Medicine. --- Neurosciences. --- Biomedicine. --- Biomedicine general. --- Embryology --- Nervous system --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Neural sciences --- Neurological sciences --- Neuroscience --- Health Workforce --- Biomedicine, general. --- Medicine --- Biology --- Neuroscience. --- Biomedical Research. --- Research. --- Biological research --- Biomedical research

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The arterial pole is one of the most complex parts of the heart both in development and disease. It involves the collaboration and orchestration of contributions from the first and second heart fields as well as the neural crest. The precursor cells differentiate into endocardial cushions and putative cardiac valves, the myocardium, and epicardium of the heart, but also into the different layers of the main arterial vessels. These include not only the aorta and the pulmonary trunk but also the pulmonary and coronary arteries, and during development, the arterial duct. Many transcriptional and signaling networks act in timely concert to acquire the proper asymmetric development and function and pressure and flow dynamics. This is not only a human or even mammalian ‘enterprise,’ but is also taking place in so-called ancestral forms from fish to reptiles, including birds. In humans, it is small wonder that many clinical syndromes may arise when something in this complexity is amiss. This Special Issue of JCDD contains contributions focussed on the heart fields, congenital cardiac malformations and associated syndromes, with special emphasis on the cardiac outflow tract. The Issue is devoted to Prof. Dr. Adriana Gittenberger-de Groot, who dedicated her extensive career to research on cardiovascular development.

transforming growth factor beta-3 --- cardiac development --- loeys dietz syndrome-5 --- arrhythmogenic right ventricular dysplasia --- rienhoff syndrome --- cleft palate --- congenital heart disease --- outflow tract septation --- signaling networks --- transcription factor AP-2α --- cardiovascular development --- outflow tract --- pharyngeal arch artery --- neural crest cell --- pharyngeal ectoderm --- Tetralogy of Fallot --- monozygotic twins --- discordant phenotype --- genetics --- variations --- epigenetics --- DNA methylation --- candidate genes --- acute aortic syndrome --- cardiovascular disease --- aorta --- aortic valve replacement --- surgical --- aortic surgery --- bicuspid aortic valve --- Bentall --- Kommerell’s diverticulum --- right sided aortic arch --- anomalous left subclavian artery --- arteria lusoria --- tracheal compression --- esophageal compression --- transposition great arteries coronary anatomy --- Rac1 --- proliferation --- cell polarity --- congenital heart defects --- compact myocardium --- trabeculation --- aortic stenosis --- asymptomatic --- early surgery --- watchful waiting --- cardiac progenitor cells --- second heart field --- neural crest --- endocardium --- cushion --- valve --- ductus arteriosus --- neointima --- tunica media --- transcriptome --- lineage tracing --- developmental biology --- cell identity --- atrioventricular valve --- epicardium --- lateral cushion --- major cushion --- myxomatous degeneration --- homograft --- semilunar valves --- aortic regurgitation --- superimposed tissue --- original leaflet --- myofibroblasts --- free edge folding --- remodeling --- dissection of ductus arteriosus --- sudden unexpected intrauterine death --- single coronary artery --- Leiden Convention coronary coding system --- Lipton classification --- coronary artery anatomy --- transposition of the great arteries --- arterial switch operation --- coronary artery --- coronary complications --- imaging --- fetal aortic stenosis --- prenatal ultrasound --- postmortem histology --- speckle tracking analysis --- endocardial fibro-elastosis --- endocardial cushions --- cartilage --- foramen of Panizza --- left aorta --- right aorta --- pulmonary trunk --- pharyngeal arch arteries --- coronary arteries --- cardiac fields --- cardiomyocyte --- progenitor specification --- heart tube --- aortic wall --- cardiovascular pathogenesis --- arterial duct

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This book outlines some new advances in genetics, clinical evaluation, localization, therapy (newly including immunotherapy) of pheochromocytoma and paraganglioma including their metastatic counterparts. Well-known and experienced clinicians and scientists contributed to this book to include some novel approaches to these tumors. This book will serve to various health care professionals from different subspecialties, but mainly oncologists, endocrinologists, endocrine surgeons, pediatricians, and radiologists. This book shows that the field of pheochromocytoma/paraganglioma is evolving and a significant progress has been made in last 5 years requiring that health care professionals and scientists will learns new information and implement it in their clinical practice or scientific work, respectively. This book should not be missed by anybody who is focusing on neuroendocrine tumors, their newest evaluation and treatment.

polycythemia --- peptide receptor radiotherapy --- n/a --- vasculogenesis --- catecholamines --- neuroendocrine --- GTV --- adaptive immunity --- therapy resistance --- histology --- transgenic mice --- cryoablation --- spheroids --- energy metabolism --- somatostatinoma --- angiogenesis --- pheochromocytoma --- SDHD --- percutaneous ethanol injection --- metanephrines --- SDHB --- global longitudinal strain --- mutation --- normetanephrines --- catecholamine --- PASS --- PGL --- 177Lu-DOTATATE --- chromosomal alteration --- speckle-tracking echocardiography --- lL-6 --- dog --- percutaneous ablation --- stem-like tumor cells --- EPAS1 --- neural crest --- fluorescence imaging --- neutrophil --- xenograft --- inflammation --- head and neck --- weighted standard deviation --- FGF21 --- calorimetry --- HIF --- average real variability --- next-generation sequencing --- adrenocortical carcinoma --- carotid body --- hypoxia-inducible factor --- paraganglioma --- succinate dehydrogenase --- blood pressure variability --- arrhythmia --- mortality --- NF1 --- toll-like receptor --- GAPP --- NET --- subclinical systolic dysfunction --- pheochromocytoma and paraganglioma --- PET-CT --- pan-cancer analysis --- mouse pheochromocytoma cells --- innate immunity --- neurogenesis --- neuroendocrine tumor --- obesity --- hypotension --- hypoxia --- CNV detection --- 18F-FDOPA --- comparative genomics --- adrenomedullary function --- PCC --- pathogen-associated molecular patterns --- adrenal tumor --- radiotherapy --- 11C-hydroxy-ephedrine --- radiofrequency ablation --- PPGL --- minimally invasive procedure --- sporadic --- diabetes mellitus --- adrenal incidentaloma --- germline mutation --- immunotherapy --- VHL --- immunohistochemistry --- metastatic OR malignant pheochromocytoma --- erythropoietin --- postoperative --- targeted therapy --- PRRT --- metastatic --- mitochondria --- T cell --- TCA cycle --- meta-analysis --- pseudohypoxia --- ectopic secretion --- radiosensitization --- chromogranin A --- hereditary --- hypertension --- PET --- phosphorylation tyrosine hydroxylase