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The sensory hair cells in the inner ear and vestibular system convert mechanical stimuli, sound and motion into neural activity that is responsible for the sensations of hearing, motion and head position. In mammals, the loss of hair cells from acoustic overstimulation, ototoxic drugs and aging is irreversible, leading to a permanent loss of function. However, it is now clear that hair cells in other vertebrates are capable of regenerating and recovering partial or complete function. Moreover, partially damaged hair cells can undergo self-repair or be protected from traumatic insults by external compounds. Hair Cell Regeneration, Repair, and Protection provides a comprehensive survey of what is currently known about the regeneration, repair and protection of sensory hair cells and subsequent recovery of function in the auditory and vestibular system. The aim is to provide graduate students, postdoctoral fellows, clinicians and scientists in related disciplines with the biological bases of hair cells and with an understanding of the factors that contribute to their regeneration and repair. Table of Contents: Overview: Regeneration and repair Richard J. Salvi Morphological Correlates of Regeneration and Repair in the Inner Ear Jason R. Meyers and Jeffrey T. Corwin The recovery of function in the avian auditory system following ototrauma James C. Saunders and Richard J. Salvi Functional recovery following hair cell regeneration in birds Robert J. Dooling, Micheal L. Dent, Amanda M. Lauer, and Brenda M. Ryals Hair cell regeneration: Mechanisms guiding cellular proliferation and differentiation Elizabeth C. Oesterle and Jennifer S. Stone Protection and repair of inner ear sensory cells Andrew Forge and Thomas R. Van De Water Gene arrays, cell lines, stem cells, and sensory regeneration in mammalian ears Marcelo N. Rivolta and Matthew C. Holley About the editors: Richard J. Salvi, Center for Hearing and Deafness, University of Buffalo, NY. Arthur N. Popper is Professor in the Department of Biology and Co-Director of the Center for Comparative and Evolutionary Biology of Hearing at the University of Maryland, College Park. Richard R. Fay is Director of the Parmly Hearing Institute and Professor of Psychology at Loyola University of Chicago.

Hair cells. --- Hair cells --- Regeneration. --- Regeneration (Biology) --- Cells of Corti --- Cochlear hair cells --- Corti's cells --- Corti's organ --- Mechanoreceptors --- Neurobiology. --- Human physiology. --- Neurosciences. --- Human Physiology. --- Neural sciences --- Neurological sciences --- Neuroscience --- Medical sciences --- Nervous system --- Human biology --- Physiology --- Human body --- Neurosciences

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The Lateral Line System provides an overview of the key concepts and issues surrounding the development, evolution, neurobiology, and function of the lateral line, a fascinating yet somewhat enigmatic flow-sensing system. The book examines the historical precedence for linking the auditory and lateral line systems, its structure and development, use of the lateral line system of zebrafish as a model system, physical principles governing the response properties of the lateral line, the behavioral relevance of this sensory system to the lives of fish, and an examination of how this information is shaped and encoded by the peripheral and central nervous systems. Contents The Gems of the Past: A Brief History of Lateral Line Research in the Context of the Hearing Sciences - Sheryl Coombs and Horst Bleckmann Morphological Diversity, Development, and Evolution of the Mechanosensory Lateral Line System - Jacqueline F. Webb The Hydrodynamic of Flow Stimuli - Matthew J. McHenry and James C. Liao The Biophysics of the Fish Lateral Line - Sietse M. van Netten and Matthew J. McHenry Sensory Ecology and Neuroethology of the Lateral Line - John Montgomery, Horst Bleckmann, and Sheryl Coombs Information Encoding and Processing by the Peripheral Lateral Line System - Boris Philippe Chagnaud and Sheryl Coombs The Central Nervous Organization of the Lateral Line System - Mario F. Wullimann and Benedikt Grothe Central Processing of Lateral Line Information - Horst Bleckmann and Joachim Mogdans Functional Overlap and Nonoverlap Between Lateral Line and Auditory Systems - Christopher B. Braun and Olav Sand The Hearing Loss, Protection, and Regeneration in the Larval Zebrafish Lateral Line - Allison B. Coffin, Heather Brignull, David W. Raible, and Edwin W Rubel About the Editors: Sheryl Coombs is Professor of Biological Science at Bowling Green State University. Horst Bleckmann is Professor in the Institute for Zoology at the University of Bonn. Arthur N. Popper is Professor in the Department of Biology and Co-Director of the Center for Comparative and Evolutionary Biology of Hearing at the University of Maryland, College Park. Richard R. Fay is Distinguished Research Professor of Psychology at Loyola University Chicago. About the series: The Springer Handbook of Auditory Research presents a series of synthetic reviews of fundamental topics dealing with auditory systems. Each volume is independent and authoritative; taken as a set, this series is the definitive resource in the field.

Hearing --- Acoustics --- Audition (Physiology) --- Physiological acoustics --- Physiological aspects. --- Fishes -- Physiology. --- Lateral line organs. --- Mechanoreceptors. --- Lateral line organs --- Cyprinidae --- Animal Structures --- Cypriniformes --- Lateral Line System --- Zebrafish --- Medicine. --- Neurosciences. --- Neurology. --- Biomedicine. --- Bioacoustics --- Senses and sensation --- Audiology --- Auditory pathways --- Deafness --- Ear --- Listening --- Medicine --- Nervous system --- Neuropsychiatry --- Neural sciences --- Neurological sciences --- Neuroscience --- Medical sciences --- Diseases --- Neurology .

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Presents findings in field of research of mechanosensitivity of the heart. This book focuses on molecular mechanisms of mechanotransduction in cardiac cells. It contains a description of several stretch-induced signaling cascades with multiple levels of crosstalk between different pathways.

Heart -- Contraction. --- Heart -- Electric properties. --- Heart -- Mechanical properties. --- Heart conduction system. --- Myocardium. --- Heart --- Mechanoreceptors --- Muscles --- Biophysical Processes --- Signal Transduction --- Biological Science Disciplines --- Cardiovascular System --- Muscle, Striated --- Natural Science Disciplines --- Biophysical Phenomena --- Musculoskeletal System --- Biochemical Processes --- Cell Physiological Processes --- Physical Processes --- Anatomy --- Myocardium --- Mechanotransduction, Cellular --- Physiology --- Disciplines and Occupations --- Biochemical Phenomena --- Physical Phenomena --- Chemical Processes --- Tissues --- Cell Physiological Phenomena --- Phenomena and Processes --- Chemical Phenomena --- Medicine --- Health & Biological Sciences --- Cardiovascular Diseases --- Mechanoreceptors. --- Cardiac conduction system --- Conducting system of the heart --- Conduction system of the heart --- Conductive system of the heart --- Connecting system of the heart --- Mechanicoreceptors --- Conduction system --- Medicine. --- Human physiology. --- Cardiology. --- Medical biochemistry. --- Cell biology. --- Biomedicine. --- Human Physiology. --- Biomedicine general. --- Cell Biology. --- Medical Biochemistry. --- Sensory receptors --- Cytology. --- Biochemistry. --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Chemistry --- Medical sciences --- Cell biology --- Cellular biology --- Cells --- Cytologists --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Pathology --- Physicians --- Internal medicine --- Human body --- Composition --- Diseases --- Biomedicine, general. --- Health Workforce --- Medical biochemistry --- Pathobiochemistry --- Pathological biochemistry --- Biochemistry

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Merkel Cell Carcinoma is one of the first comprehensive, single-source clinical texts on the subject. Although not as common as melanoma, Merkel cell carcinoma is not rare – and it is both more deadly than melanoma and increasing at an epidemic rate. The book is clinical in focus and emphasizes treatment of this poorly understood cancer. Contributing authors include dermatologists, surgical oncologists, radiation oncologists, and medical oncologists from the US and around the world. Features: Comprehensive single-source clinical reference Treatment focus Written for practitioners, with emphasis on clinical relevance and quick retrieval of information Contributing authors represent all disciplines involved in treatment of Merkel cell carcinoma: dermatology, surgical oncology, radiation oncology, and medical oncology International in perspective, with contributors from US and abroad Members of active Merkel Cell Carcinoma Multicenter Interest Group have authored some of the chapters.

Carcinoma, Merkel cell. --- Medicine. --- Merkel cell carcinoma. --- Merkel cell carcinoma --- Medicine --- Neoplasms by Site --- Carcinoma, Neuroendocrine --- Mechanoreceptors --- Neoplasms --- Health Occupations --- Sensory Receptor Cells --- Neuroendocrine Tumors --- Neuroectodermal Tumors --- Neurons, Afferent --- Disciplines and Occupations --- Diseases --- Neurons --- Neoplasms, Germ Cell and Embryonal --- Neoplasms by Histologic Type --- Nervous System --- Anatomy --- Carcinoma, Merkel Cell --- Merkel Cells --- Pathology --- Skin Neoplasms --- Health & Biological Sciences --- Dermatology --- Merkel cells. --- Cancer. --- Cancers --- Carcinoma --- Malignancy (Cancer) --- Malignant tumors --- Dermatology. --- Oncology. --- Surgical oncology. --- Medicine & Public Health. --- Surgical Oncology. --- Tumors --- Epithelial cells --- Oncology  . --- Cancer --- Oncologic surgery --- Oncological surgery --- Surgical oncology --- Skin --- Excision --- Treatment

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Signal Transduction, 2e, is a thorough, well-illustrated study in cellular signaling processes. Beginning with the basics, this book shows how cells respond to external cues, hormones, growth factors, cytokines, cell surfaces, etc., and further instructs how these inputs are integrated. Instruction continues with up-to-date, inclusive coverage of intracellular calcium, nuclear receptors, tyrosine protein kinases and adaptive immunity, and targeting transduction pathways for research and medical intervention. Signal Transduction, 2e, serves as an invaluable resource

Pharmaceutical chemistry --- Drugs --- Chimie pharmaceutique --- Médicaments --- Design --- Conception --- Pharmaceutical chemistry. --- Chimie pharmaceutique (Trad. du MeSH) --- Modèles chimiques (Trad. du MeSH) --- Chimie pharmaceutique. --- Pharmaceutical Preparations --- Design. --- Conception. --- chemistry. (MeSH - aucune traduction) --- Chemical models. --- Drugs. --- Pharmaceutical Preparations. --- Chemistry, Pharmaceutical --- Models, Chemical --- Chemistry --- Models, Theoretical --- Pharmacology --- Chemicals and Drugs --- Investigative Techniques --- Biological Science Disciplines --- Natural Science Disciplines --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Disciplines and Occupations --- Pharmacy, Therapeutics, & Pharmacology --- Health & Biological Sciences --- Médicaments --- Drug design --- Pharmaceutical design --- Drug development --- Chemistry, Medical and pharmaceutical --- Drug chemistry --- Medical chemistry --- Medicinal chemistry --- Pharmacochemistry --- Cellular signal transduction. --- Mechanotransduction, Cellular --- Cellular Mechanotransduction --- Mechanosensory Transduction --- Signal Transduction, Mechanical --- Mechanical Signal Transduction --- Transduction, Mechanosensory --- Podosomes --- Mechanoreceptors --- Cellular information transduction --- Information transduction, Cellular --- Signal transduction, Cellular --- Bioenergetics --- Cellular control mechanisms --- Information theory in biology --- Signal Transduction. --- Transduction du signal cellulaire --- Cellular signal transduction --- ELSEVIER-B EPUB-LIV-FT --- Cellular control mechanisms. --- Cell regulation --- Biological control systems --- Cell metabolism --- chemistry