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This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact

chemokine --- CVB3 --- Hantavirus --- hcmv --- HIV --- Inflammation --- influenza --- interferon

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This innovative study charts the beginnings, history and fate of Interferon - one of modern medicine's most famous and infamous drugs. Interferon is part of the medical profession's armoury against viral infection, cancer and MS. The story of its development and use is one of survival in the face of remarkable cycles of promise and disappointment as a miracle drug. By telling this story, Toine Pieters' book provides insight into the research, manufacture, and marketing of new bio-molecules that mark modern medical science. Pieters' closely argued book adopts a multi-disciplinary approach i

Interferon --- Interferon industry --- Pharmaceutical industry --- Interferons --- Antineoplastic agents --- Antiviral agents --- Glycoproteins --- Lymphokines --- History. --- Drug Industry --- Technology, Pharmaceutical --- Interférons --- therapeutic use. --- economics. --- trends. --- history. --- methods. --- History --- Histoire

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The Finnish doctor Kari Cantell is one of the scientists to whom the development of the drugs called interferons can be attributed. Interferons have achieved an important place in the treatment of cancer, viral infections and multiple sclerosis. In the 1960s Cantell and his coworkers developed a method for the preparation of interferon in white blood cells. During those years, most of the global production of interferon took place in Finland and the vast majority of the clinical studies in the world employed Finnish interferon.The memoirs of Cantell record interferon's long road from the labor

Immunologists --- Interferon --- Interferons --- Antineoplastic agents --- Antiviral agents --- Glycoproteins --- Lymphokines --- Immunology --- Medical scientists --- Biography. --- Research --- History. --- Cantell, K. --- Cantell, Kari

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Over the last half of century interferon (IFN), originally discovered as an antiviral protein, has developed from an inhibitor of viral replication to a major force in the antiviral response. Initially studied only by few virologists, IFN was generally considered as a poorly defined protein of limited importance. The development of molecular techniques lead to the identification of a family of IFN genes and has shown an unexpected complexity of type I IFN genes and their expression. Presently, some aspects of the of the pathogen mediated induction of IFN gene expression are understood at molecular level, while others are still at the stage of description. Both Toll like receptors and cytoplasmic RNA helicases were shown to recognize viral nucleic acids and the basis of a distinct recognition of viral nucleic acids from the cellular ones are emerging. Important insights on the virus recognition entity, leading to the expression of interferon and interferon induced genes, have been made in the recent year, which are challenging the accepted concept of the critical role of dsRNA in IFN induction. The availability of genetically modified mice that are lacking either essential components of the interferon inducing pathway, or interferon signaling pathway fully confirmed the original idea, made soon after its discovery, that interferon is the first cellular defense against viral infection.

Interferon. --- Interferons --- Antineoplastic agents --- Antiviral agents --- Glycoproteins --- Lymphokines --- Immunology. --- Medical virology. --- Virology. --- Medical microbiology --- Virology --- Virus diseases --- Immunobiology --- Life sciences --- Serology --- Microbiology

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This comprehensive volume, written by experts in the field, emphasizes the most recent advances on the Hepatitis C virus infection (HCV) moving from basic research to clinical application. In spite of the numerous studies on HCV infection, its pathogenesis and medical treatment have not been fully explained. The first chapters of this volume analyize the full spectrum of immune responses to HCV taking into account either innate or adoptive immunity involvement. The volume also includes a series of contributions which explain the state of art of IFN-alpha treatment in HCV patients and the effectiveness of therapy also in relation to HCV genotypes. The use and applications of pegylated IFNs will also be discussed as well as the complicated HCV disease and its treatment. Hepatitis C Virus Disease: Immunobiology and Clinical Applications is an ideal volume for researchers, scientists, professionals, clinicians, physicians and graduate students in the fields of infectious disease, immunology, virology, microbiology, pharmacology and medicine.

Hepatitis C --- Interferon --- Treatment. --- Therapeutic use. --- Medicine. --- Immunology. --- Virology. --- Biomedicine. --- Microbiology --- Immunobiology --- Life sciences --- Serology --- Clinical sciences --- Medical profession --- Human biology --- Medical sciences --- Pathology --- Physicians --- Hepatitis, Non-A, non-B --- Non-A, non-B hepatitis, Parenterally-transmitted --- Parenterally-transmitted non-A, non-B hepatitis --- Flaviviral diseases --- Hepatitis, Viral --- Medical virology. --- Medical microbiology --- Virology --- Virus diseases