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La neutronique – néologisme bâti sur le modèle d’électronique – est née en 1932 avec la mise en évidence expérimentale du neutron par le physicien britannique James Chadwick. La neutronique est l’étude du cheminement des neutrons dans la matière et, plus spécifiquement, des conditions d’une réaction en chaîne libérant de l’énergie grâce aux fissions de noyaux d’uranium ou de plutonium. À la suite de talentueux pionniers de la physique nucléaire – Becquerel, les Curie, les Joliot-Curie et bien d’autres – et encouragés par une politique volontariste de développement de cette nouvelle source d’énergie, les physiciens français ont apporté une contribution essentielle aux progrès de la neutronique. Basée à l’origine sur des modèles extrêmement habiles, la neutronique a fait de plus en plus appel à l’informatique. Aujourd’hui, les concepteurs des réacteurs font partie des gros utilisateurs du calcul scientifique. Cette saga est contée ici par un ingénieur qui a contribué à ces développements et un enseignant qui a transmis sa passion à de nombreux jeunes. L’auteur a choisi de la présenter avec deux niveaux de difficulté : le lecteur rebuté par les équations ou ne recherchant qu’un aperçu pourra se limiter au texte principal ; celui qui souhaite plus de détails pourra aussi se plonger dans les encadrés.
Neutrons. --- Nuclear physics. --- Atomic nuclei --- Atoms, Nuclei of --- Nucleus of the atom --- Atoms --- Baryons --- Matter --- Particles (Nuclear physics) --- Physics --- Constitution --- Hepatitis B --- Hepatitis, Viral, Human
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Gastroenterology --- Hepatitis, Viral --- Hepatitis, Viral, Animal --- Hepatitis, Viral, Human --- Hépatite virale --- Periodicals --- periodicals --- Périodiques --- Hepatitis, Viral, Animal. --- Hepatitis, Viral, Human. --- Hepatitis, Viral. --- Hépatite. --- Agriculture Sciences --- Health Sciences --- Life Sciences --- Soil Chemistry, Microbiology, Fertility & Fertilizers --- Clinical Medicine --- General and Others --- Virology --- Virushepatitis --- Zeitschrift --- Online-Ressource --- Virology. --- Hepatitis. --- Hépatite virale --- Périodiques --- EBSCOASP-E EJMEDEC EPUB-ALPHA-J EPUB-PER-FT MDGASTRO WILEY-E --- Viral hepatitis --- Virus hepatitis --- Netzpublikation --- Online-Publikation --- Computerdatei im Fernzugriff --- Online-Dokument --- On-line-Dokument --- On-line-Publikation --- Periodikum --- Zeitschriften --- periodicals. --- Liver --- Virus diseases --- Viral Hepatitis, Human --- Human Viral Hepatitides --- Human Viral Hepatitis --- Viral Hepatitides, Human --- Viral Hepatitis, Animal --- Animal Viral Hepatitides --- Animal Viral Hepatitis --- Viral Hepatitides, Animal --- Elektronische Publikation --- Presse --- Fortlaufendes Sammelwerk --- Hepatitis --- Virusinfektion --- Diseases --- Gastro-enterologie
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Viral Hepatitis in Children: Unique Features and Opportunities is a unique volume that has been created to address the special considerations regarding viral hepatitis in children. It includes the latest information and recommendations specifically directed at the pediatric population, and highlights the knowledge gaps which will need to be filled to improve our understanding of these infections and treatment of this special group. Experienced practitioners from around the world have contributed these reviews, incorporating the latest studies, the current recommendations, and the distinctive pediatric issues that shape clinical care. This material will determine the research agenda for this field going forward. Viral Hepatitis in Children: Unique Features and Opportunities is a valuable resource for pediatricians, pediatric gastroenterologists, hepatologists and infectious disease specialists that care for children with viral hepatitis.
Hepatitis, Viral. --- Liver -- Diseases. --- Pediatric gastroenterology. --- Hepatitis, Viral, in children --- Pediatric gastroenterology --- Virus Diseases --- Age Groups --- Hepatitis --- Persons --- Diseases --- Liver Diseases --- Hepatitis, Viral, Human --- Adolescent --- Child --- Infant --- Named Groups --- Digestive System Diseases --- Medicine --- Health & Biological Sciences --- Pediatrics --- Gastroenterology --- Hepatitis, Viral, in children. --- Pediatrics. --- Paediatrics --- Pediatric medicine --- Medicine. --- Gastroenterology. --- Hepatology. --- Medicine & Public Health. --- Children --- Health and hygiene --- Hepatitis in children --- Virus diseases in children --- Clinical medicine. --- Medicine, Clinical --- Internal medicine --- Digestive organs --- Gastroenterology .
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Human medicine --- Hepatitis, Viral, Human --- Liver Neoplasms --- Flaviviridae Infections --- Drug Resistance, Microbial --- Virus Physiological Phenomena --- Hepadnaviridae Infections --- Adenocarcinoma --- Carcinoma, Hepatocellular --- Hepatitis C --- Drug Resistance, Viral --- Hepatitis B --- Hepatitis --- Microbiological Phenomena --- Digestive System Neoplasms --- Drug Resistance --- Virus Diseases --- Carcinoma --- DNA Virus Infections --- RNA Virus Infections --- Liver Diseases --- Digestive System Diseases --- Neoplasms by Site --- Diseases --- Phenomena and Processes --- Neoplasms, Glandular and Epithelial --- Pharmacological Phenomena --- Neoplasms --- Neoplasms by Histologic Type --- Physiological Phenomena
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Liver disease has been identified as a leading cause of death in HIV-infected patients since the introduction of highly active antiretroviral therapy (HAART) in 1996. The HIV treatment community has been caught largely unaware of this emerging dilemma. Many HIV care providers are ill-equipped to understand and interpret liver injury patterns, or to provide comprehensive care and management for viral coinfections which they are not familiar with. HIV and Liver Disease provides a comprehensive update of the field covering the epidemiology, pathogenesis, management and treatment of liver disease in patients with HIV infection. The volume will help HIV care providers understand and interpret liver injury patterns, and/or provide comprehensive care and management for viral coinfections. Gastroenterologists and hepatologists will gain an understanding of complex drug regimens that are used to treat HIV and which may impact HCV and HBV treatment. Written by expert clinicians and researchers across multiple disciplines, HIV and Liver Disease will be of great value to gastroenterologists, hepatologists, infectious disease practitioners, as well as other health care providers who provide care or participate in research in the field of HIV.
HIV infections -- Complications. --- HIV infections. --- Liver -- Diseases. --- Liver --- HIV infections --- Virus Diseases --- Sexually Transmitted Diseases, Viral --- Drug Therapy, Combination --- Digestive System Diseases --- Hepatitis --- Immunologic Deficiency Syndromes --- Lentivirus Infections --- Drug Therapy --- Diseases --- Retroviridae Infections --- Immune System Diseases --- Sexually Transmitted Diseases --- Therapeutics --- RNA Virus Infections --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Hepatitis, Viral, Human --- HIV Infections --- Liver Diseases --- Antiretroviral Therapy, Highly Active --- Medicine --- Health & Biological Sciences --- Gastroenterology --- Complications --- Diseases. --- HIV (Viruses) infections --- HTLV-III infections --- HTLV-III-LAV infections --- Human T-lymphotropic virus III infections --- Medicine. --- Internal medicine. --- Gastroenterology. --- Hepatology. --- Medicine & Public Health. --- Internal Medicine. --- Lentivirus infections --- Sexually transmitted diseases --- Clinical medicine. --- Medicine, Internal --- Medicine, Clinical --- Internal medicine --- Digestive organs --- Gastroenterology .
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Hepatitis C virus (HCV), a major causative agent of chronic liver disease, is spread throughout the world and around 170 million people are persistently infected. In this volume, world-leading experts in the field of HCV research have compiled the most recent scientific advances to provide a comprehensive and very timely overview of the various facets of HCV. The book starts with a discussion of the possible origin of HCV and its spread among the human population. The focus of the subsequent chapters is on available cell culture and in vivo models before shifting to the molecular and cellular principles underlying the viral replication cycle. These chapters are complemented by insightful descriptions of the innate and adaptive immune responses to HCV as well as the virus-associated pathogenesis. Finally, the development of antiviral therapies, which is closely linked with progress in basic research, and the implementation of those therapies into present and future daily clinical practice are highlighted.
Hepacivirus. --- Hepatitis C virus. --- Hepatitis C virus --- Viral Vaccines --- Hepatitis, Viral, Human --- Flaviviridae --- Hepatitis Viruses --- Flaviviridae Infections --- Viruses --- Vaccines --- RNA Viruses --- Virus Diseases --- RNA Virus Infections --- Hepatitis --- Vertebrate Viruses --- Diseases --- Organisms --- Biological Products --- Liver Diseases --- Complex Mixtures --- Digestive System Diseases --- Chemicals and Drugs --- Viral Hepatitis Vaccines --- Hepacivirus --- Hepatitis C --- Biology --- Health & Biological Sciences --- Microbiology & Immunology --- Immunology. --- Medical virology. --- Immunobiology --- HCV (Hepatitis C virus) --- Medicine. --- Drug resistance. --- Virology. --- Hepatology. --- Biomedicine. --- Drug Resistance. --- Life sciences --- Serology --- Gastroenterology --- Microbiology --- Resistance to drugs --- Pharmacology --- Clinical sciences --- Medical profession --- Human biology --- Medical sciences --- Pathology --- Physicians --- Medical microbiology --- Virology --- Virus diseases --- Flaviviruses --- Hepatitis viruses --- Drug interactions. --- Clinical medicine. --- Interactions, Drug --- Drugs --- Medicine, Clinical --- Medicine --- Side effects
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Chronic viral hepatitis affect hundreds of millions of people worldwide, and each year millions more people become infected. In Chronic Viral Hepatitis, Second Edition, a panel of distinguished clinicians and clinical investigators build upon the first edition by comprehensively reviewing all the relevant new information regarding resistance, side effects, and therapies for chronic viral hepatitis. The text covers recent advances in the understanding of pathogenesis of viral hepatitis while discussing promising agents in development for its treatment. The authors devote special attention to reactivation of hepatitis B with chemotherapy and immunosuppression, herbal and non-traditional therapies, chronic viral hepatitis in the pediatric population, and immunology and immunotherapy of HCV and provide relative costs for all diagnostic and therapeutic options. Authoritative and up-to-date, Chronic Viral Hepatitis, Second Edition offers today's gastroenterologists, internists, hepatologists, and infectious disease specialists a practical guide to the recognition, diagnosis and treatment of chronic viral hepatitis from a multidisciplinary approach.
Hepatitis B virus -- Physiological effect. --- Hepatitis C virus -- Physiological effect. --- Hepatitis, Viral -- Treatment. --- Hepatitis, Viral. --- Hepatitis, Viral --- Hepatitis B virus --- Hepatitis C virus --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Hepatitis --- Virus Diseases --- Disease Attributes --- Pathologic Processes --- Liver Diseases --- Diseases --- Pathological Conditions, Signs and Symptoms --- Digestive System Diseases --- Hepatitis, Viral, Human --- Diagnosis --- Chronic Disease --- Medicine --- Health & Biological Sciences --- Gastroenterology --- Treatment --- Physiological effect --- Liver --- Viral hepatitis --- Virus hepatitis --- Diseases. --- Medicine. --- Gastroenterology. --- Medicine & Public Health. --- Internal medicine --- Digestive organs --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Virus diseases --- Gastroenterology .
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Hepatitis E (HEV) is a viral infectious disease that infects humans and domestic, wild, and synanthropic animals alike. In developing countries, the disease often presents as an epidemic, transmitted primarily through the fecal-oral route. In recent years, sporadic cases have also been documented in industrial countries, including Europe. The identification and characterization of animal strains of HEV from pigs, wild boar, and deer, and the demonstrated ability of cross-species infection by these animal strains raise potential public health concerns for foodborne and zoonotic transmission of the virus. This Brief will provide a thorough overview of HEV. It will discuss the epidemiology and pathogenesis of the virus in both humans and animals, review detection methods, and provide methods for its control and prevention.
Hepatitis, Viral. --- Hepatitis E --- Emerging infectious diseases --- Hepatitis, Viral, Human --- Communicable Diseases --- Hepatitis Viruses --- Infection --- Viruses --- Virus Diseases --- Bacterial Infections and Mycoses --- Organisms --- Diseases --- Communicable Diseases, Emerging --- Hepatitis E virus --- Biology --- Health & Biological Sciences --- Microbiology & Immunology --- Hepatitis E. --- Hepatitis. --- Liver --- Enterically-transmitted non-A, non-B hepatitis --- Epidemic non-A, non-B hepatitis --- Hepatitis, Non-A, non-B --- Non-A, non-B hepatitis, Enterically-transmitted --- Waterborne hepatitis --- Inflammation --- Medicine. --- Virology. --- Food --- Infectious diseases. --- Biomedicine. --- Food Science. --- Infectious Diseases. --- Medicine/Public Health, general. --- Biotechnology. --- Hepatitis, Viral --- Medical virology. --- Food science. --- Emerging infectious diseases. --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Emerging infections --- New infectious diseases --- Re-emerging infectious diseases --- Reemerging infectious diseases --- Communicable diseases --- Science --- Medical microbiology --- Virology --- Virus diseases --- Health Workforce --- Food—Biotechnology. --- Microbiology
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Chronic Hepatitis C Virus: Advances in Treatment, Promise for the Future documents the monumental advances that have been made in our understanding of chronic HCV during the past decade. The first section reviews the natural history of chronic HCV, how this virus can affect other organs in addition to the liver, and whether treating chronic HCV alters the natural history of this disease. Section 2 reviews the advances that have been made in the treatment of chronic HCV during the past decade with interferon based therapy. Separate chapters on response guided therapy and how to manage the adverse events associated with these medications provide the physician with the concepts required to more effectively treat chronic HCV now and in the future. As the genetics of virologic response have recently been elucidated, a chapter is devoted to helping the clinician understand how genes that modulate disease processes and their treatment are identified and utilized in clinical care. Section 3 deals with the future of HCV treatment and specific inhibitors of HCV. Specific chapters explain how targets for drugs are identified and how drugs are then developed and tested; how mutations of HCV develop and how anti-viral agents will affect this process; the most up to date data regarding the treatment of chronic HCV with peginterferon, ribavirin and anti-viral agents; and the potential to treat chronic HCV with just oral anti-viral agents and without peginterferon and ribavirin in the future. The final section of this book covers issues related to liver transplantation in patients with chronic HCV. Separate chapters review the natural history of chronic HCV in liver transplant recipients and the impact of utilizing HCV positive donors. The volume concludes with chapters that cover the treatment of chronic HCV both prior to and after liver transplantation with potent anti-viral agents. Chronic Hepatitis C Virus: Advances in Treatment, Promise for the Future is a valuable resource for all physicians caring for patients with chronic HCV.
Chronic diseases -- Treatment. --- Hepatitis C -- Treatment. --- Hepatitis, Chronic --- Flaviviridae --- Tissue Transplantation --- Hepatitis Viruses --- Hepatitis C --- Digestive System Surgical Procedures --- Anti-Infective Agents --- Organ Transplantation --- Transplantation --- Hepatitis --- Viruses --- Hepatitis, Viral, Human --- Therapeutic Uses --- Surgical Procedures, Operative --- Flaviviridae Infections --- RNA Viruses --- Vertebrate Viruses --- Liver Diseases --- Organisms --- Virus Diseases --- Pharmacologic Actions --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- RNA Virus Infections --- Digestive System Diseases --- Chemical Actions and Uses --- Diseases --- Chemicals and Drugs --- Hepatitis C, Chronic --- Liver Transplantation --- Antiviral Agents --- Hepacivirus --- Medicine --- Health & Biological Sciences --- Gastroenterology --- Hepatitis C. --- Liver --- Chronic diseases. --- Diseases. --- Diseases, Chronic --- NCDs (Noncommunicable diseases) --- Non-communicable diseases --- Non-infectious diseases --- Noncommunicable diseases --- Hepatitis, Non-A, non-B --- Non-A, non-B hepatitis, Parenterally-transmitted --- Parenterally-transmitted non-A, non-B hepatitis --- Medicine. --- Gastroenterology. --- Hepatology. --- Medicine & Public Health. --- Flaviviral diseases --- Hepatitis, Viral --- Clinical medicine. --- Internal medicine --- Digestive organs --- Medicine, Clinical --- Gastroenterology .
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In 1947, Lerner and Watson showed that the cold-precipitable proteins in serum were gammaglobulins. These “cryoglobulins” were responsible for the corresponding clinical condition “cryoglobulinemia.” Meltzer and Franklin, in 1966, provided an accurate description of the typical clinical symptoms associated with cryoglobulinemia. Subsequent progress in this field was rather slow until the end of the 1980s, when cryoglobulinemia was definitively shown to be an extrahepatic manifestation of hepatitis C virus infection. The book is unique in its detailed presentation and fundamental approach. Highly qualified authors have contributed critical articles reviewing significant developments in our understanding of and therapeutic approach to HCV infection and cryoglobulinemia. The text is accompanied by striking color images and illustrations and highly informative tables. This comprehensive review of a systemic disease with a complex etiology is a valuable source of up-to-date, expert information not only for basic scientists and specialists in several disciplines but also for general practitioners as well as graduate and post-graduate students in clinical and medical research.
Cryoglobulinemia. --- Hepatitis C. --- Cryoglobulinemia --- Paraproteinemias --- Hemostatic Disorders --- Hepatitis C --- Flaviviridae --- Hepatitis, Chronic --- Vascular Diseases --- Medicine --- Hepatitis Viruses --- Blood Protein Disorders --- RNA Viruses --- Hepatitis --- Immunoproliferative Disorders --- Hepatitis, Viral, Human --- Health Occupations --- Cardiovascular Diseases --- Flaviviridae Infections --- Viruses --- Hemorrhagic Disorders --- Hematologic Diseases --- Virus Diseases --- Liver Diseases --- Diseases --- Vertebrate Viruses --- RNA Virus Infections --- Disciplines and Occupations --- Immune System Diseases --- Organisms --- Hemic and Lymphatic Diseases --- Digestive System Diseases --- Hepacivirus --- Hepatitis C, Chronic --- Pathology --- Vasculitis --- Health & Biological Sciences --- Urology & Nephrology --- Gastroenterology --- Cryogammaglobulinemia --- Hepatitis, Non-A, non-B --- Non-A, non-B hepatitis, Parenterally-transmitted --- Parenterally-transmitted non-A, non-B hepatitis --- Medicine. --- Internal medicine. --- Hepatology. --- Infectious diseases. --- Oncology. --- Rheumatology. --- Medicine & Public Health. --- Internal Medicine. --- Infectious Diseases. --- Flaviviral diseases --- Hepatitis, Viral --- Paraproteinemia --- Clinical medicine. --- Emerging infectious diseases. --- Oncology . --- Tumors --- Internal medicine --- Connective tissues --- Joints --- Emerging infections --- New infectious diseases --- Re-emerging infectious diseases --- Reemerging infectious diseases --- Communicable diseases --- Medicine, Internal --- Medicine, Clinical
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