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Responding to a renewed interest in the growing problem of iodine deficiency worldwide, Drs. Charles Oxnard and Peter Obendorf, along with experienced translator and anatomist John Dennison, take a fresh look at the classic text, Der endemische Kretinismus, published in 1936 by Springer. Translated here for the first time into English, this landmark text will be a welcome resource for researchers confronting the problem of iodine deficiency. Oxnard and Obendorf point out that there is very little detailed knowledge or numerical data on cretinism available in the English-speaking world.  In addition, highly-renowned Professor Basil S. Hetzel, recently-retired World Health Organization Chairman of the International Council for Control of Iodine Deficiency Disorders, published in 2009 with Dr Chen Zu-pei on the resurgence of iodine deficiency in China.  Indeed, throughout the entire developing world there may be as many as two billion people at risk to iodine deficiency; perhaps three quarters of a billion have goiter, and ten million may be cretins.  Even in developed countries, iodine deficiency is re-emerging (as in New South Wales in 19% of children) with the result of significantly reduced numbers of gifted children (though this is not cretinism per se). Certain to be of significant interest to a wide range of researchers, health providers and professionals, including government health administrators, this English translation of Endemic Cretinism is a major contribution to the literature.

Congenital Hypothyroidism. --- Cretinism. --- Endemic Diseases. --- Endemic goiter. --- Cretinism --- Endemic goiter --- Dwarfism --- Bone Diseases, Endocrine --- Hypothyroidism --- Thyroid Diseases --- Genetic Diseases, Inborn --- Endocrine System Diseases --- Bone Diseases --- Bone Diseases, Developmental --- Congenital, Hereditary, and Neonatal Diseases and Abnormalities --- Musculoskeletal Diseases --- Diseases --- Congenital Hypothyroidism --- Medicine --- Health & Biological Sciences --- Clinical Endocrinology --- Epidemiology. --- Congenial hypothyrodism --- Medicine. --- Internal medicine. --- Endocrinology. --- Neurology. --- Medicine & Public Health. --- Internal Medicine. --- Public health --- Congenital myxedema --- Endemic cretinism --- Fetal iodine deficiency disorder --- Iodine deficiency diseases --- Newborn infants --- Nervous system --- Neuropsychiatry --- Medicine, Internal --- Internal medicine --- Hormones --- Endocrinology . --- Neurology .

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Iodine, a key component of thyroid hormones, is considered an essential micronutrient for proper health at all life stages. Indeed, an inadequate dietary intake of iodine is responsible for several functional and developmental abnormalities. The most serious consequences of iodine deficiency include hypothyroidism, early abortion, low birth weight, preterm delivery, neurocognitive impairment, and mental retardation. On the other hand, the consequences of mild-to-moderate iodine deficiency, such as goiter, are less well understood but represent an important priority for research and public health practice. Over the last several decades, many countries across the globe have introduced mandatory salt iodization programs, which have dramatically reduced the number of iodine-deficient countries. However, despite substantial progress worldwide, mild-to-moderate deficiency is still prevalent even in many developed countries. Thus, the ongoing monitoring of the population iodine status remains crucially important, and attention may need to be paid to vulnerable life stage groups.

iodine deficiency --- schoolchildren --- pregnancy --- iodine prophylaxis --- iodine deficiency disorders --- goiter --- hypothyroidism --- nutraceuticals --- thyroid function --- dietary supplements --- urinary iodine concentration --- iodine --- thyroid hormones --- thyroglobulin --- thyroid stimulating hormone --- preterm birth --- small for gestational age --- iodine nutrition status --- thyroid disease --- thyrotropin --- urine iodine --- epidemiologic studies --- Korean --- Republic of Moldova --- salt --- sodium --- potassium --- population --- Iodine Status --- Food Frequency Questionnaire --- iodized salt --- iodine intake --- dairy intake --- adults --- iodine status --- human milk --- lactation --- infant growth --- iodine schoolchildren --- goitre --- iodised salt --- water iodine --- iodine pregnant women --- cadmium --- myo-inositol --- seleno-L-methionine --- thyroid --- MCP-1 --- CXCL10 --- carnitine --- flavonoids --- melatonin --- omega-3 --- resveratrol --- selenium --- vitamins --- zinc --- n/a --- perchlorate --- Natrium/Iodide symporter --- endocrine disruptors --- review --- drinking and Food --- Hypothyroidism