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Over the past decade there have been major advances in the field of regenerative medicine with the promise to bring to reality, cures for debilitating diseases such as diabetes, heart failure, and Parkinson’s disease. Cellular products from a variety of sources are being evaluated for their ability to replace damaged tissue. Fetal tissues consist of stem cells and progenitor cells which have undergone initial commitment with varying states of differentiation. Stem cells from fetal tissues may also have a greater proliferative potential than their adult counterparts. In addition, fetal derived stem and progenitor cells are immunologically naive and some sources of fetal cells, eg cord blood, have been shown to be capable of crossing greater HLA mismatching resulting in less rejection and decreased immune mediated toxicities. Given the increasing focus on HES and advances in our basic knowledge of regenerative medicine it is an appropriate time to review the biology and use of fetal tissues. Human Fetal Tissue Transplantation is a timely publication that provides details of many aspects of the potential use of fetal tissues for therapeutic applications. As many tissues are wasted on a daily basis it appropriate to raise discussion on how to maximize access to discard tissue and at the same time engage in discussion of the ethics associated with fetal tissue procurement and clinical use.

Fetal tissue. --- Fetus -- Research. --- Human experimentation in medicine. --- Medicine. --- Fetus --- Health Services --- Investigative Techniques --- Tissue Transplantation --- Embryonic Structures --- Biological Science Disciplines --- Transplantation --- Natural Science Disciplines --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Anatomy --- Health Care Facilities, Manpower, and Services --- Disciplines and Occupations --- Surgical Procedures, Operative --- Health Care --- Physiology --- Tissue and Organ Procurement --- Fetal Tissue Transplantation --- Fetal Research --- Medicine --- Health & Biological Sciences --- Pathology --- Research --- Fetal tissues --- Transplantation. --- Hematology. --- Pathology. --- Medicine & Public Health. --- Disease (Pathology) --- Medical sciences --- Diseases --- Medicine, Preventive --- Haematology --- Internal medicine --- Blood

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The first edition of Color Atlas of Fetal and Neonatal Histology was an important step in updating the histology texts available to practicing pathologists and pathology trainees who perform fetal autopsy and/or participate in research involving fetal tissues. It was a well-received volume that filled a major gap in pathology references related to normal histology and provided a comprehensive, state-of-the art review of fetal and neonatal histology. While the basics of fetal histology have changed little in the intervening years since publication of the first edition, this successor edition provides new insights and a fresh perspective. This book contains six new chapters including: blood vessels and lymphatics, external genitalia, eye, ear, skin, and maceration changes. Many existing chapters have also been expanded to address a greater breadth of fetal and neonatal histology such as postnatal testis development and the cardiac conduction system. The “Special Considerations” sections were also expanded in many chapters to address particularly problematic issues within individual organ systems. The book reviews the histology of the major organ systems in the fetus and neonate and provides detailed images, up-to-date references, and practical guidelines for identifying tissues across all gestational ages of development. The second edition of Color Atlas of Fetal and Neonatal Histology serves as the ultimate go-to resource for pathologists and researchers dealing with, and interested in, fetal and neonatal histology. It provides a comprehensive summary of the current status of the field with excellent and extensive illustrative examples that help guide the clinical study of fetal and neonatal histology and stimulate investigative efforts with fetal tissue. .

Histology --- Pathology. --- Pediatrics. --- Paediatrics --- Pediatric medicine --- Medicine --- Children --- Disease (Pathology) --- Medical sciences --- Diseases --- Medicine, Preventive --- Health and hygiene --- Fetus. --- Newborn infants. --- Infant, Newborn --- Newborns --- Neonate --- Infants, Newborn --- Neonates --- Newborn --- Newborn Infant --- Newborn Infants --- Neonatology --- Fetal Tissue --- Fetuses --- Mummified Fetus --- Retained Fetus --- Fetal Structures --- Fetal Structure --- Fetal Tissues --- Fetus, Mummified --- Fetus, Retained --- Structure, Fetal --- Structures, Fetal --- Tissue, Fetal --- Tissues, Fetal --- Embryo, Mammalian --- Fetal Research --- Infants (Newborn) --- Newborns (Infants) --- Infants --- Foetus --- Unborn child --- Embryology --- Reproduction

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The idea that we have an unlimited moral imperative to pursue medical research is deeply rooted in American society and medicine. In this provocative work, Daniel Callahan exposes the ways in which such a seemingly high and humane ideal can be corrupted and distorted into a harmful practice. Medical research, with its power to attract money and political support, and its promise of cures for a wide range of medical burdens, has good and bad sides-which are often indistinguishable. In What Price Better Health?, Callahan teases out the distinctions and differences, revealing the difficulties that result when the research imperative is suffused with excessive zeal, adulterated by the profit motive, or used to justify cutting moral corners. Exploring the National Institutes of Health's annual budget, the inflated estimates of health care cost savings that result from research, the high prices charged by drug companies, the use and misuse of human subjects for medical testing, and the controversies surrounding human cloning and stem cell research, Callahan clarifies the fine line between doing good and doing harm in the name of medical progress. His work shows that medical research must be understood in light of other social and economic needs and how even the research imperative, dedicated to the highest human good, has its limits.

Morals --- Ethics, Research --- Research --- Medicine --- Health Workforce --- Laboratory Research --- Research Activities --- Research and Development --- Research Priorities --- Activities, Research --- Activity, Research --- Development and Research --- Priorities, Research --- Priority, Research --- Research Activity --- Research Priority --- Research, Laboratory --- Research Ethics --- Human Experimentation --- Animal Experimentation --- Embryo Research --- Fetal Research --- Morality --- Retrospective Moral Judgment --- Social aspects --- ethics --- american medicine. --- american society. --- annual budgets. --- bioethics. --- boundaries of science. --- capitalist society. --- controversial. --- drug companies. --- economic needs. --- health care costs. --- health care system. --- health researchers. --- human cloning. --- human subjects. --- limits of research. --- medical burdens. --- medical progress. --- medical research. --- medical testing. --- moral issues. --- morality. --- political history. --- profit motives. --- research imperative. --- social needs. --- sociology. --- stem cell research.

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Obstetrics --- Perinatology --- Newborn infants --- Neonatology --- Pregnancy Complications. --- Perinatal Care. --- Fetal Diseases. --- Fetus. --- Infant, Newborn, Diseases. --- Obstétrique --- Périnatalogie --- Nouveau-nés --- Néonatologie --- Neonatology. --- Obstetrics. --- Perinatology. --- Diseases --- Maladies --- Diseases. --- Medicine, Perinatal --- Perinatal medicine --- Maternal-fetal medicine --- Neonatal pediatrics --- Neonatal Diseases --- Disease, Neonatal --- Diseases, Neonatal --- Neonatal Disease --- Fetal Tissue --- Fetuses --- Mummified Fetus --- Retained Fetus --- Fetal Structures --- Fetal Structure --- Fetal Tissues --- Fetus, Mummified --- Fetus, Retained --- Structure, Fetal --- Structures, Fetal --- Tissue, Fetal --- Tissues, Fetal --- Embryopathies --- Disease, Fetal --- Diseases, Fetal --- Embryopathy --- Fetal Disease --- Care, Perinatal --- Complications, Pregnancy --- Complication, Pregnancy --- Pregnancy Complication --- Pregnancy --- Infants (Newborn) --- Neonates --- Newborns (Infants) --- complications --- Pregnancy Complications --- Perinatal Care --- Fetal Diseases --- Fetus --- Infant, Newborn, Diseases --- periodicals. --- Pediatrics --- Medicine --- Infants --- Pregnancy, High-Risk --- Embryo, Mammalian --- Fetal Research --- Fetal Diseases.. --- Grossesse --- Périnatalité. --- Fœtus --- Fœtus. --- Complications. --- Maladies. --- Foetus --- Unborn child --- Embryology --- Reproduction --- Complications of pregnancy --- High-risk pregnancy --- Pregnancy, Complications of --- Pregnant women --- Obstetrical emergencies --- Complications --- Neonatologia --- Pediatria --- Infants nadons --- Perinatologia --- Infants prematurs --- Obstetrícia

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In Lost, medical historian Shannon Withycombe weaves together women's personal writings and doctors' publications from the 1820s through the 1910s to investigate the transformative changes in how Americans conceptualized pregnancy, understood miscarriage, and interpreted fetal tissue over the course of the nineteenth century. Withycombe's pathbreaking research reveals how Americans construed, and continue to understand, miscarriage within a context of reproductive desires, expectations, and abilities. This is the first book to utilize women's own writings about miscarriage to explore the individual understandings of pregnancy loss and the multiple social and medical forces that helped to shape those perceptions. What emerges from Withycombe's work is unlike most medicalization narratives.

MEDICAL / General. --- Miscarriage --- Obstetricians --- Abortion, Spontaneous --- Pregnancy --- Fetal Research --- History, 19th Century --- 19th Cent. History (Medicine) --- 19th Cent. History of Medicine --- 19th Cent. Medicine --- Historical Events, 19th Century --- History of Medicine, 19th Cent. --- History, Nineteenth Century --- Medical History, 19th Cent. --- Medicine, 19th Cent. --- 19th Century History --- 19th Cent. Histories (Medicine) --- 19th Century Histories --- Cent. Histories, 19th (Medicine) --- Cent. History, 19th (Medicine) --- Century Histories, 19th --- Century Histories, Nineteenth --- Century History, 19th --- Century History, Nineteenth --- Histories, 19th Cent. (Medicine) --- Histories, 19th Century --- Histories, Nineteenth Century --- History, 19th Cent. (Medicine) --- Nineteenth Century Histories --- Nineteenth Century History --- Birth attendants --- Physicians --- Spontaneous abortion --- Fetal death --- History --- Psychological aspects --- history --- psychology --- United States. --- United States --- miscarriage, women, women's health, public health, pregnancy, reproduction, family.