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Begins with an historical overview of the early discoveries surrounding DNA methylation in the mammalian brain and then explores the evidence supporting a role for this epigenetic mechanism in controlling gene expression programs across the lifespan in both normal and diseased states. Chapters describe new directions and technological advances, and provide an overview of what the future holds for this exciting new field. This book is ideal for medical, graduate and advanced undergraduate students, but is also a great resource for researchers who need a broad introduction to the dynamic nature of DNA that sheds light on evolving concepts of gene-environment interaction and their effects on adaptation and neuropsychiatric disease.--
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Prokaryotic gene expression is not only of theoretical interest but also of highly practical significance. It has implications for other biological problems, such as developmental biology and cancer, brings insights into genetic engineering and expression systems, and has consequences for important aspects of applied research. For example, the molecular basis of bacterial pathogenicity has implications for new antibiotics and in crop development. Prokaryotic Gene; Expression is a major review of the subject, providing up-to-date coverage as well as numerous insights by the prestigious authors. Topics covered include operons; protein recognition of sequence specific DNA- and RNA-binding sites; promoters; sigma factors, and variant tRNA polymerases; repressors and activators;; post-transcriptional control and attenuation; ribonuclease activity, mRNA stability, and translational repression; prokaryotic DNA topology, topoisomerases, and gene expression; regulatory networks, regulatory cascades and signal transduction; phosphotransfer reactions; switch systems, transcriptional and translational modulation, methylation, and recombination mechanisms; pathogenicity, toxin regulation and virulence determinants; sporulation and genetic regulation of antibiotic production;; origins of regulatory molecules, selective pressures and evolution of prokaryotic regulatory mechanisms systems. Over 1100 references to the primary literature are cited. Prokaryotic Gene Expression is a comprehensive and authoritative review of current knowledge and research in the area. It is; essential reading for postgraduates and researchers in the field. Advanced undergraduates in biochemistry, molecular biology, and microbiology will also find this book useful.
Gene expression. --- Genes --- Genetic regulation --- Expression
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Over the past decade, the transient gene expression (TGE) technology platform has been actively pursued to produce a wide range of therapeutic proteins, monoclonal antibodies, and vaccines for mainly preclinical assessment, due to its short development times and low overall cost. This book updates the latest advances in the field, with focusing on systematic description of the technology from cell lines, cell culture conditions, vector construction, expression strategy, current protocols, optimisation of the procedure, and potential for clinical application. As a conclusion, the author foresee
Gene expression. --- Genes --- Genetic regulation --- Expression
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Gene expression --- Genes --- Genetic regulation --- Expression
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In this edition of PULP fictions two law students reflect on the issues taken up in the first edition of PULP fictions in 2005. Joel Modiri and Emile Zitzke ... after reading the dialogue between Heyns and van Marle ... were prompted to revisit some of the issues raised.
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Grondrechten. Een enkele fascist, communist of jihadist daargelaten, draagt iedereen ze hoog in het vaandel. Tot je naar de praktijk kijkt: vaandelvlucht volgt zodra rechten ongemakkelijk worden. En ongemakkelijk zijn ze. Onvermijdelijk ongemakkelijk. Ze laten veel ruimte voor choquerend of ronduit vulgair gedrag. De Grondwet is er tenslotte ook voor racisten, hooligans en homofoben. 00Veel politici en beleidsmakers daarentegen lijken slechts gelukkig als ze allerlei ongewenst gedrag bij wet kunnen verbieden. Of het nu gaat om boerkini?s, negationisme of seksisme: de relatiestatus tussen Wetstraat en rechtsstaat laat zich in het gunstigste geval omschrijven als it?s complicated. 00Recht werkt bovendien vaak averechts. Ongewenst gedrag bestrijden door het te verbieden en te sanctioneren lijkt aantrekkelijk in al zijn eenvoud. Maar het heeft ook de diepgang van een surfplank: de realiteit laat zich niet zomaar sturen door inktvlekken op papier, zelfs niet als ze in het Staatsblad staan. 00Grondrechtenspecialist en rechtsantropoloog Jogchum Vrielink neemt de actualiteit op de korrel. Hij laat steevast een tegengeluid horen wanneer de waan van dag het dreigt te halen en spaart daarbij links noch rechts. 'Pro Deo' bundelt zijn snijdende opiniestukken. Het zijn beschouwingen van een opiniemaker-in-bijberoep. Geboren uit noodzaak: omdat Twitter maar 140 tekens toelaat.
Freedom of expression. --- Expression, Freedom of --- Free expression --- Liberty of expression --- Civil rights
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One of the great political writers of our time offers a manifesto for global free speech in the digital age Never in human history was there such a chance for freedom of expression. If we have Internet access, any one of us can publish almost anything we like and potentially reach an audience of millions. Never was there a time when the evils of unlimited speech flowed so easily across frontiers: violent intimidation, gross violations of privacy, tidal waves of abuse. A pastor burns a Koran in Florida and UN officials die in Afghanistan. Drawing on a lifetime of writing about dictatorships and dissidents, Timothy Garton Ash argues that in this connected world that he calls cosmopolis, the way to combine freedom and diversity is to have more but also better free speech. Across all cultural divides we must strive to agree on how we disagree. He draws on a thirteen-language global online project-freespeechdebate.com-conducted out of Oxford University and devoted to doing just that. With vivid examples, from his personal experience of China's Orwellian censorship apparatus to the controversy around Charlie Hebdo to a very English court case involving food writer Nigella Lawson, he proposes a framework for civilized conflict in a world where we are all becoming neighbors.
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Neuropeptide Analogs, Conjugates, and Fragments
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