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Conus is the largest genus of animals in the sea, occurring throughout the world's tropical and subtropical oceans and contributing significantly to marine biodiversity. The shells of these marine mollusks are prized for their amazing variety and extraordinary beauty. The neurotoxic venoms they produce-injected by a hollow, harpoon-like tooth into prey animals that are then paralyzed and swallowed whole-have a range of pharmaceutical applications, from painkillers to antidepressants. This beautifully illustrated book identifies 53 valid species of the southeastern United States and the Caribbean, a region that supports a diverse but taxonomically challenging group of Conus. Introductory chapters cover the evolution and phylogeny of the genus, and notes on methodology are provided. Detailed species accounts describe key identification features, taxonomy, distribution, ecology, toxicology, life history, and evolutionary relationships. The book includes more than 2,100 photos of shells on 109 splendid color plates; more than 100 additional photos, many depicting live animals in color; and 35 color distribution maps. Identifies 53 valid species-the first reassessment of western Atlantic Conus in more than seventy years Features more than 2,100 photos of shells on 109 color plates Blends the traditional shell-character approach to identification with cutting-edge shell and radular tooth morphometrics and molecular genetic analyses Includes color images of live animals as well as color distribution maps
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Neurosciences --- Brain --- Cerebrum --- Mind --- Central nervous system --- Head --- Neural sciences --- Neurological sciences --- Neuroscience --- Medical sciences --- Nervous system --- History --- Physiology --- History. --- Spinal Cord --- Coccygeal Cord --- Conus Medullaris --- Conus Terminalis --- Lumbar Cord --- Medulla Spinalis --- Myelon --- Sacral Cord --- Thoracic Cord --- Coccygeal Cords --- Conus Medullari --- Conus Terminali --- Cord, Coccygeal --- Cord, Lumbar --- Cord, Sacral --- Cord, Spinal --- Cord, Thoracic --- Cords, Coccygeal --- Cords, Lumbar --- Cords, Sacral --- Cords, Spinal --- Cords, Thoracic --- Lumbar Cords --- Medulla Spinali --- Medullari, Conus --- Medullaris, Conus --- Myelons --- Sacral Cords --- Spinal Cords --- Spinali, Medulla --- Spinalis, Medulla --- Terminali, Conus --- Terminalis, Conus --- Thoracic Cords --- Cauda Equina --- Encephalon
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Neurotrauma and Critical Care of the Spine, 2nd edition, by a distinguished critical care neurosurgeon, Jack Jallo, and a renowned spine surgeon, Alexander Vaccaro, incorporates salient components of the highly praised first edition. The updated text reflects cutting-edge discussion on spine injury management in a neurocritical care setting. Contributions from top experts in neurosurgery, orthopaedic surgery, neurology, critical care, cardiac and pulmonary care, and trauma surgery infuse this book with a well-rounded perspective. From the pre-hospital to intensive care setting, this unique reference provides a comprehensive, yet concise approach to the treatment of acute spinal cord injury and management of patients with chronic SCI. Chapters new to this edition include neurological assessment of spinal injury, clearing the cervical spine, management of concurrent TBI and spinal injury, blood pressure and oxygen management, temperature management, fluids and osmotherapy, pharmacology, autonomic dysreflexia, infection after SCI, and emerging therapies.
Spinal cord --- Spinal cord. --- Spine. --- Wounds and injuries. --- Injuries and Wounds --- Injuries, Wounds --- Research-Related Injuries --- Wounds --- Wounds and Injury --- Wounds, Injury --- Injuries --- Trauma --- Injuries, Research-Related --- Injury --- Injury and Wounds --- Injury, Research-Related --- Research Related Injuries --- Research-Related Injury --- Traumas --- Wound --- First Aid --- Traumatology --- Vertebra --- Spinal Column --- Vertebrae --- Vertebral Column --- Column, Spinal --- Column, Vertebral --- Columns, Spinal --- Columns, Vertebral --- Spinal Columns --- Vertebral Columns --- Coccygeal Cord --- Conus Medullaris --- Conus Terminalis --- Lumbar Cord --- Medulla Spinalis --- Myelon --- Sacral Cord --- Thoracic Cord --- Coccygeal Cords --- Conus Medullari --- Conus Terminali --- Cord, Coccygeal --- Cord, Lumbar --- Cord, Sacral --- Cord, Spinal --- Cord, Thoracic --- Cords, Coccygeal --- Cords, Lumbar --- Cords, Sacral --- Cords, Spinal --- Cords, Thoracic --- Lumbar Cords --- Medulla Spinali --- Medullari, Conus --- Medullaris, Conus --- Myelons --- Sacral Cords --- Spinal Cords --- Spinali, Medulla --- Spinalis, Medulla --- Terminali, Conus --- Terminalis, Conus --- Thoracic Cords --- Cauda Equina
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Marine Drugs is glad to announce its first Special Issue book on “ion channels” related research: Under the great stewardship of the Guest Editor, Dr. Jean-Marc Sabatier, four advanced research articles and three comprehensive review papers were collected in the Special Issue “Ion Channels as Marine Drug Targets”. Join us to explore the advanced research outcomes in this field: α-Conotoxin RgIA and a potent analog, RgIA4, in treatment of pain; botulinum toxin-chitosan nanoparticles in treatment of atrial fibrillation; 27-amino acid (aa)-long δ-conotoxin TxVIA that modulates mammalian CaV3.x; first venomics study of Conus tulipa venom; review on marine toxins targeting Kv1 channels; review on synthetic approaches to zetekitoxin AB; and review on marine natural products and drug resistance in latent tuberculosis. The second edition of this Special Issue is open for submissions, we look forward to your contribution.
conotoxin --- Conus tulipa --- intraspecific variation --- venomics --- transcriptomics --- proteomics --- conantokins --- net hunting strategy --- nirvana cabal --- ion channel modulators --- marine anti-TB compounds --- PZA --- MTB --- latent TB --- sponges --- nicotinic --- chemotherapy --- paclitaxel --- taxane --- neuropathic pain --- α9α10 --- saxitoxin --- zetekitoxin AB --- voltage-gated sodium channel --- guanidine alkaloid --- bioactives --- conotoxins 2 --- Kv1 --- marine toxins --- modulators --- potassium channels --- sea anemone toxins --- TxVIA --- mammalian NaV channel --- selective inhibitor --- T-type CaV3.2 --- botulinum toxin A1 --- chitosan nanoparticles --- antiarrhythmics --- pharmacological models of arrhythmia --- electrically induced arrhythmia
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This Special Issue Book, “Marine Bioactive Peptides: Structure, Function, andTherapeutic Potential"" includes up-to-date information regarding bioactivepeptides isolated from marine organisms. Marine peptides have been found invarious phyla, and their numbers have grown in recent years. These peptidesare diverse in structure and possess broad-spectrum activities that have greatpotential for medical applications. Various marine peptides are evolutionaryancient molecular factors of innate immunity that play a key role in host defense.A plethora of biological activities, including antibacterial, antifungal, antiviral,anticancer, anticoagulant, endotoxin-binding, immune-modulating, etc., makemarine peptides an attractive molecular basis for drug design. This Special IssueBook presents new results in the isolation, structural elucidation, functionalcharacterization, and therapeutic potential evaluation of peptides found inmarine organisms. Chemical synthesis and biotechnological production of marinepeptides and their mimetics is also a focus of this Special Issue Book.
cone snail --- tilapia --- n/a --- animal models --- BRICHOS domain --- recombinant peptide --- calcium absorption --- plastein reaction --- antioxidant activity --- endothelial dysfunction --- C3a --- lung cancer --- invertebrate immunity --- identification --- zinc bioavailability --- NA-inhibitory peptide --- nuclear magnetic resonance (NMR) --- review --- ACE-inhibitory activity --- intestinal absorption --- hairtail (Trichiurus japonicas) --- DU-145 cells --- peptide --- crustacean --- venom duct --- Kalloconus --- drug design --- molecular symmetry --- arenicin --- ?-helix --- APETx2 --- conotoxins --- functional diversity --- docking --- conotoxin --- neuraminidase --- angiotensin II --- polychaeta --- influenza virus --- phylogeny --- gene expression --- host defense peptide --- Perinereis aibuhitensis --- anti-diabetic activity --- conopeptides --- SHRs --- Chlorella pyrenoidosa protein hydrolysate (CPPH) --- metastasis --- Caco-2 cell monolayer --- Nrf2 --- caco-2 cells --- HUVEC --- PYP15 --- sea cucumber --- decapeptide --- cytotoxic --- arenicin-1 --- marine peptides --- cell proliferation --- Conus --- Conus ateralbus --- self-production of hydrogen peroxide --- antimicrobial activity --- molecular dynamics --- machine learning --- tachyplesins --- ion channels --- gut microbiota --- Anthopleura anjunae oligopeptide --- signaling pathways --- half-fin anchovy hydrolysates --- NF-?B --- Chlorella pyrenoidosa protein hydrolysate-calcium chelate (CPPH-Ca) --- antihypertensive effect --- QAGLSPVR --- antimicrobial peptides --- vasculogenic mimicry --- antibacterial --- ?-hairpin --- innate immunity --- transcriptome sequencing --- HIF-1? --- Gracilariopsis lemaneiformis --- function --- ACE-inhibitory peptide --- complement --- peptide-zinc complex --- structure-activity relationship --- multi-functional peptides --- cod skin --- adsorption --- Maillard reaction products --- molecular docking --- antibacterial peptide --- PI3K/AKT/mTOR signaling pathway --- Arenicola marina --- structure–activity relationship --- antimicrobial peptide --- Rana-box --- acid-sensing ion channel --- Neptunea arthritica cumingii --- apoptosis --- membrane damage --- proteolytic system --- toxin --- polyphemusins --- computational studies --- muscle --- oyster zinc-binding peptide --- abalone --- pain relief --- transport routes --- cytotoxicity --- dexamethasone --- cell death --- host?microbe relationship --- anti-LPS factor --- MMPs --- protein synthesis --- structure --- Pyropia yezoensis peptide --- cone snails --- chemical synthesis --- prostate cancer --- Ugr 9-1 --- myotube atrophy
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The rapid aging of populations in developed countries since the 2000s has placed increasing attention on the issue of musculoskeletal disorders in elderly patients. Notably, spinal disorders not only restrict the social activities of elderly patients, but they also lead to economic loss for society. “Current Advances in Spinal Diseases of Elderly Patients” is a topical collection of articles about current perspectives on diagnosis and treatment of spinal disorders including current surgical strategies. This Special Issue covers a broad range of issues, ranging from managing refractory states such as severe osteoporosis, spinal deformity, ossification of the spinal ligaments, and multiple arthropathy to managing lifestyle-related spinal diseases during the COVID-19 pandemic in elderly populations. We hope that the readers of this Special Issue find the contents interesting.
spinal metastasis --- non-small cell lung cancer --- decompression --- survival --- prognosis --- epidermal growth factor receptor --- Uno’s C-index --- New England Spinal Metastasis Score --- trunk muscle --- bioelectrical impedance analysis --- MRI --- back muscle strength --- epidemiological study --- osteoporosis --- osteopenia --- locomotive syndrome --- two-step test --- frailty --- cervical myelopathy --- hand grip strength --- falls --- postoperative --- human nonmercaptalbumin --- reduced albumin --- oxidative stress --- spinal sagittal alignment --- low back pain --- health-related quality of life --- conus medullaris --- height --- pelvic incidence --- magnetic resonance imaging --- healthy volunteers --- n/a --- gender differences --- spine arthrodesis --- spinal fusion --- spine --- deformity --- direct lateral corpectomy --- expandable cage --- global alignment --- local kyphosis --- osteoporosis vertebral fracture --- cervical spine --- clinical findings --- computed tomography --- diffuse idiopathic skeletal hyperostosis --- ossification of the posterior longitudinal ligament --- pain --- patient-reported outcomes --- whole spine --- prevalence --- influence factor --- spinal alignment --- aging --- total knee arthroplasty --- lumbar lordosis --- sagittal spinopelvic parameters --- clinical outcome --- cervical ossification of the posterior longitudinal ligament --- whole-spine computed tomography --- grading system --- multicenter study --- adult spinal deformity (ASD) --- posterior lumbar interbody fusion --- lateral lumbar interbody fusion --- sagittal correction --- perioperative complications --- surgical invasiveness --- degenerative adult deformity --- anterior cervical corpectomy and fusion --- hybrid fusion --- implant failure --- graft subsidence --- complications --- perioperative outcomes --- fusion rate --- segmental paralysis --- mechanical stability --- resident cohort --- resident registry --- spinal balance --- gender --- adult spine --- osteoporotic vertebral fracture --- residual pain --- visual analog scale --- quality of life --- adult spine deformity --- adult spine fusion --- deformity correction --- perioperative parameters --- ODI --- VAS --- disability --- T1 slope --- C2-7 SVA --- C2-7 angle --- back pain --- brace --- spine orthoses --- lumbar support --- spine support --- COVID-19 --- pandemic --- spinal disorder --- elderly --- exercise habit --- female --- activities of daily living --- nutrition --- health checkup data --- full-endoscopic lumbar discectomy --- recurrent herniation --- early recurrence --- Uno's C-index
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