Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact

neuronal Ca2+ sensors --- calcium signaling --- molecular basis of disease --- calcium bindind proteins --- neurological disorders

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Apoptosis: Involvement of Oxidative Stress and Intracellular Ca2+ Homeostasis, presents a concise synthesis of the current knowledge and recent advances in the mechanisms of apoptosis in different cells and the role of oxidative stress and Ca2+ signalling. Particular attention is given to the different features of apoptosis in distinct cell types, ranging from hepatocytes to cardiovascular and blood cells, nervous cells or spermatozoa. Cutting-edge and user-friendly, this volume serves as a comprehensive resource for those interested in the fascinating biological processes associated to programmed cell death or apoptosis. The book is divided in two major chapter sections: general mechanisms of the apoptotic pathways and the role of oxidative stress and intracellular Ca2+ homeostasis and a more specific section dedicated to the specificities of apoptosis in a number of excitable and non-excitable cells. All of the contributions are from specialists in the field and the reviews presented, systemically examine the most exciting and innovative aspects of the apoptotic pathways in their particular areas of expertise.

Apoptosis. --- Cellular signal transduction. --- Homeostasis. --- Intracellular calcium. --- Oxidative stress. --- Apoptosis --- Oxidative stress --- Intracellular calcium --- Cellular signal transduction --- Homeostasis --- Cell Death --- Second Messenger Systems --- Ion Transport --- Physiological Processes --- Stress, Physiological --- Metabolism --- Metabolic Phenomena --- Cell Physiological Processes --- Biological Transport --- Physiological Phenomena --- Signal Transduction --- Phenomena and Processes --- Biochemical Processes --- Cell Physiological Phenomena --- Biochemical Phenomena --- Chemical Processes --- Chemical Phenomena --- Oxidative Stress --- Calcium Signaling --- Biology --- Health & Biological Sciences --- Cytology --- Cell metabolism. --- Cells --- Medicine. --- Cancer research. --- Oncology. --- Cell biology. --- Cell physiology. --- Biomedicine. --- Cancer Research. --- Cell Biology. --- Cell Physiology. --- Cell death --- Cellular control mechanisms --- Oncology  . --- Cytology. --- Cell function --- Physiology --- Cell biology --- Cellular biology --- Cytologists --- Tumors --- Cancer research

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

The book considers signaling events from the zygote embryo through to the blastocyst with relevant data from embryonic stem (ES) cells, including dialogue with the extracellular environment and with the maternal tract during the implantation process. Application of the knowledge described to improve the success of human and animal assisted conception is considered where appropriate, but the focus is largely on fundamental rather than applied cell/molecular biology, as this is the area that has historically been neglected. While the general features of metabolism during preimplantation development are well established, especially in terms of nutrient requirements, uptake and fate, remarkably little is known about early embryo signaling events, intracellular or intercellular, between individual embryos in vitro or with the female reproductive tract in vivo. This contrasts with the wealth of information on cell signaling in somatic cells and tissues, as a glance at any textbook of biochemistry illustrates. This lack of information is such that our understanding of the molecular cell biology of early embryos -- a prerequisite to defining the mechanisms which regulate development at this critical stage of the life cycle -- is seriously incomplete. This volume is the first to address this issue by describing the current state of knowledge on cell signaling during mammalian early embryo development and highlighting priority areas for research.

Life Sciences. --- Embryology. --- Cell Biology. --- Reproductive Medicine. --- Life sciences. --- Cytology. --- Sciences de la vie --- Cytologie --- Embryologie --- Cells. --- Embryos. --- Mammals -- Reproduction. --- Embryology --- Mammals --- Embryonic stem cells --- Cellular signal transduction --- Cell interaction --- Embryonic and Fetal Development --- Cell Physiological Processes --- Biochemical Processes --- Embryonic Structures --- Stem Cells --- Second Messenger Systems --- Cell Physiological Phenomena --- Cells --- Anatomy --- Biochemical Phenomena --- Morphogenesis --- Reproduction --- Growth and Development --- Chemical Phenomena --- Phenomena and Processes --- Physiological Processes --- Reproductive Physiological Processes --- Reproductive Physiological Phenomena --- Physiological Phenomena --- Reproductive and Urinary Physiological Phenomena --- Cell Communication --- Embryonic Stem Cells --- Embryonic Induction --- Embryo Implantation --- Embryonic Development --- Calcium Signaling --- Signal Transduction --- Embryo, Mammalian --- Biology --- Health & Biological Sciences --- Biophysics --- Embryos --- Reproduction. --- Animal embryos --- Animals --- Reproductive medicine. --- Cell biology. --- Animal embryology --- Development, Embryological --- Development, Embryonic --- Development, Zygotic --- Embryogenesis --- Embryogeny --- Embryological development --- Embryonic development --- Zoology --- Zygote development --- Zygotes --- Zygotic development --- Zygotic embryogenesis --- Developmental biology --- Morphology (Animals) --- Cell biology --- Cellular biology --- Cytologists --- Human reproduction --- Human reproductive health --- Human reproductive medicine --- Reproductive medicine --- Health --- Biosciences --- Sciences, Life --- Science --- Development --- Health aspects --- Organisms --- Cytology

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

This volume contains a unique selection of chapters covering a wealth of contemporary topics in this ubiquitous and diverse system of cell signaling. It offers much more than the accessibility and authority of a primary text book, exploring topics ranging from the fundamental aspects of calcium signaling to its varied clinical implications. It presents comprehensive discussion of cutting-edge research alongside detailed analysis of critical issues, at the same time as setting out testable hypotheses that point the way to future scientific endeavors. The contributions feature material on theoretical and methodological topics as well as related subjects including mathematical modeling and simulations. They examine calcium signaling in a host of contexts, from mammalian cells to oocytes, zebrafish and plants. With much of interest to newcomers to the field as well as seasoned experts, this new publication is both wide-ranging and authoritative.

Calcium -- Physiological effect. --- Calcium in the body. --- Cellular signal transduction. --- Blood Coagulation Factors --- Metals, Alkaline Earth --- Second Messenger Systems --- Biochemical Processes --- Ion Transport --- Cell Physiological Processes --- Biological Factors --- Biological Transport --- Chemical Processes --- Biochemical Phenomena --- Elements --- Metals --- Cell Physiological Phenomena --- Chemical Phenomena --- Phenomena and Processes --- Metabolism --- Inorganic Chemicals --- Chemicals and Drugs --- Metabolic Phenomena --- Calcium --- Calcium Signaling --- Signal Transduction --- Human Anatomy & Physiology --- Medicine --- Health & Biological Sciences --- Animal Biochemistry --- Medical Research --- Cell interaction. --- Calcium. --- Cell-cell interaction --- Cell communication --- Cellular communication (Biology) --- Cellular interaction --- Intercellular communication --- Medicine. --- Neurosciences. --- Proteins. --- Cell biology. --- Cell physiology. --- Biomedicine. --- Biomedicine general. --- Receptors. --- Cell Biology. --- Cell Physiology. --- Cell function --- Cytology --- Physiology --- Cell biology --- Cellular biology --- Biology --- Cells --- Cytologists --- Proteids --- Biomolecules --- Polypeptides --- Proteomics --- Neural sciences --- Neurological sciences --- Neuroscience --- Medical sciences --- Nervous system --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Pathology --- Physicians --- Cellular control mechanisms --- Alkaline earth metals --- High-calcium diet --- Cell receptors. --- Cytology. --- Cell membrane receptors --- Cell surface receptors --- Receptors, Cell --- Binding sites (Biochemistry) --- Cell membranes --- Proteins --- Health Workforce --- Proteins . --- Biomedicine, general.

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Almost 25 years ago, the first mammalian transient receptor potential (TRP) channel was cloned and published. TRP channels now represent an extended family of 28 members fulfilling multiple roles in the living organism. Identified functions include control of body temperature, transmitter release, mineral homeostasis, chemical sensing, and survival mechanisms in a challenging environment. The TRP channel superfamily covers six families: TRPC with C for “canonical”, TRPA with A for “ankyrin”, TRPM with M for “melastatin”, TRPML with ML for “mucolipidin”, TRPP with P for “polycystin”, and TRPV with V for “vanilloid”. Over the last few years, new findings on TRP channels have confirmed their exceptional function as cellular sensors and effectors. This Special Book features a collection of 8 reviews and 7 original articles published in “Cells” summarizing the current state-of-the-art on TRP channel research, with a main focus on TRP channel activation, their physiological and pathophysiological function, and their roles as pharmacological targets for future therapeutic options.

n/a --- transient receptor potential channels --- photochromic ligands --- elementary immunology --- Purkinje cell --- EPSC --- substance P --- chemicals --- organ toxicity --- lymphocytes --- HSP70 --- physiology --- bioavailable --- inflammatory bowel disease --- platelets --- pollutants --- yeast --- regulatory T cells --- kinase --- Saccharomyces cerevisiae --- manganese --- cerebellum --- TRP channel --- NHERF --- inflammation --- nanoHPLC-ESI MS/MS --- TRPM7 --- chemical probes --- TRPM8 --- dorsal column nuclei --- TRPV2 --- TRPV3 --- calcitonin gene-related peptide --- TRPV1 --- ion channels --- transient receptor potential --- 2D gel electrophoresis --- MALDI-TOF MS(/MS) --- TRPV4 --- overproduction --- sulfur mustard --- oxidative stress --- graft versus host disease --- menthol --- topical --- chemosensor --- AP18 --- calcium signalling --- mucosal epithelium --- cuneate nucleus --- production platform --- TRPC channels --- ulcerative colitis --- channel structure --- xerostomia --- neutrophils --- cardiovascular system --- TRPC5 --- TRPC6 --- TRPC3 --- TRPC4 --- calcium signaling --- protein purification --- adipose tissue --- transient receptor potential (TRP) channels --- sodium --- TH17 --- diacylglycerol --- hypersensitivity --- TRPY1 --- GABAB --- HEK293 --- thrombosis --- ion channel --- TRPC --- pathophysiology --- SMAD --- toxicology --- endothelium --- calcium --- proteomics --- TRPA1 --- salivary glands --- TRP channels --- lipid mediators --- sensors --- radiation --- TRPM4 channel --- human medulla oblongata --- mGluR1 --- small molecules --- TRPC3 pharmacology