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Biochemistry of Drug Metabolizing Enzymes: Trends and Challenges is a complete and well-integrated reference on their mechanisms of action, their role in diseases, agents responsible for their deactivation, and their malfunction. Chapters explain the biochemistry of DMEs, including biochemical activation, functions, computational approaches, different contaminants on the action and function of DMEs, and describe the importance of DMEs in the drug development process. Conditions covered include metabolic diseases, cardiovascular diseases, neurological diseases, physiological diseases, xenobiotics and inflammatory responses, and their contribution in the malfunctioning of drug metabolizing enzymes.

Enzymes --- Biotransformation (Metabolism) --- Biotechnology. --- Activation, Metabolic --- Bioactivation (Metabolism) --- Biodegradation (Metabolism) --- Metabolic activation --- Metabolism --- Pharmacology --- Enzymology. --- Drugs --- Biotransformation --- Pharmaceutical Preparations --- Metabolism. --- metabolism

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This work which is abundantly illustrated expounds the major role of bacteria in the protection of the environment and in the biochemical mechanisms of the biodegradations of polluting substances. Each reader will find this book useful as a tool. One can use it according to one's objectives by finding relevant information in the remarkable glossary and the long bibliography that is suggested.

Biotransformation (Metabolism) --- Biodegradation. --- Biocorrosion --- Biodecay --- Biodecomposition --- Biodeterioration --- Biological corrosion --- Biological decay --- Biological decomposition --- Biological degradation --- Decay, Biological --- Decomposition (Biology) --- Degradation, Biological --- Activation, Metabolic --- Bioactivation (Metabolism) --- Biodegradation (Metabolism) --- Metabolic activation --- Biochemistry --- Decomposition (Chemistry) --- Microbiology --- Metabolism --- Pharmacology

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I have always been interested in chemistry and biology. My undergraduate, graduate, and postdoctoral trainings in pharmacy, medicinal chemistry and pharmacology, respectively, have strengthened this interest and led me to realize that significant advances in medicine have frequently been realized because of research at the chem- try–biology interface. I am hoping that this comprehensive volume on recent advances in bioactivation research will stimulate pharmacologists, medicinal chemists, phar- ceutical scientists, and graduate students in these fields and related areas to consider and use bioactivation research when they explore and chart new frontiers in drug design and drug development and when they consider ways to reduce the side effects of existing drugs by making prodrugs. As for the toxicologists and environmental health scientists, I hope this volume will help them generate the knowledge needed to understand better mechanisms of toxicity to improve human risk assessments and intervention methods after occupational or environmental exposure to various hazardous chemicals. Adnan A. Elfarra, Ph. D. vii Part I General Concepts and Basic Mechanisms 1 Metabolic Concerns in Drug Design Jeffrey P. Jones Department of Chemistry, Washington State University, Pullman, WA 99164, USA e-mail: jpj@wsu. edu Keywords: Cytochrome P450 Aldehyde Oxidase Drug–Drug Interactions Mechanism-based Virtual Screening ADMET Regioselectivity 1. 1. Introduction Due to recent technological innovations, such as genomics, combinatorial chemistry, and high-throughput screening, the identification of disease targets and of compounds that are active against these targets (‘‘leads’’) can now be carried out efficiently.

Biomedicine. --- Pharmacology/Toxicology. --- Immunology. --- Medicine. --- Toxicology. --- Médecine --- Immunologie --- Toxicologie --- Biotransformation (Metabolism). --- Biotransformation. --- Drug activation. --- Biotransformation (Metabolism) --- Drug activation --- Pharmacological Processes --- Metabolism --- Metabolic Phenomena --- Pharmacological Phenomena --- Physiological Processes --- Physiological Phenomena --- Phenomena and Processes --- Biotransformation --- Human Anatomy & Physiology --- Health & Biological Sciences --- Animal Biochemistry --- Activation, Metabolic --- Bioactivation (Metabolism) --- Biodegradation (Metabolism) --- Metabolic activation --- Activation of drugs --- Drugs --- Activation --- Pharmacology. --- Pharmacology --- Immunobiology --- Life sciences --- Serology --- Chemicals --- Medicine --- Poisoning --- Poisons --- Toxicology --- Drug effects --- Medical pharmacology --- Medical sciences --- Chemotherapy --- Pharmacy --- Physiological effect

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Biotransformation of Pesticides is an updated, ""one-stop"" resource for academic, industry and regulatory scientists involved in research and regulatory activities related to pesticide biotransformation and human health. This book provides an in depth look at how pesticides are biotransformed, which is essential to understanding exposure, dose, toxicity and health risks. This essential reference contains the biotransformation of pesticides from uptake to excretion, including toxicokinetics and emphasizes metabolism in non-target species, including experimental animals and huma

Biotransformation (Metabolism). --- Pesticides - Environmental aspects. --- Pesticides -- Environmental aspects. --- Pesticides - Metabolism. --- Pesticides - Toxicology. --- Pesticides. --- Pesticides --- Human Anatomy & Physiology --- Health & Biological Sciences --- Physiology --- Toxicology --- Environmental aspects --- Metabolism --- Toxicology. --- Environmental aspects. --- Metabolism. --- Economic poisons --- Agricultural chemicals --- Pests --- Poisons --- Pesticide pollution --- Pesticide residues --- Pesticides and the environment --- Control --- Equipment and supplies

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This book is principally concerned with the relatively complex small molecules produced by plants, which are important as drugs, fine chemicals, fragrances, flavours and biologically-active dietary constituents. In a wide-ranging series of thematic essays, it covers key aspects of their role in plant ecology, their metabolism in the plant, their discovery, characterisation and use and their significance in the diet. Biotechnology, including prospects for the genetic engineering of metabolic pathways, for biotransformations and also for the production of biologically-active proteins, is the foc

Plant products. --- Plant metabolites. --- Botanical chemistry. --- Metabolism, Secondary. --- Plant products --- Biotransformation (Metabolism) --- Activation, Metabolic --- Bioactivation (Metabolism) --- Biodegradation (Metabolism) --- Metabolic activation --- Metabolism --- Pharmacology --- Products, Plant --- Biological products --- Crops --- Farm produce --- Secondary metabolism --- Phytochemistry --- Plant biochemistry --- Plant chemistry --- Biochemistry --- Botany --- Phytochemicals --- Plant biochemical genetics --- Metabolites --- Analysis.