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This publication summarizes the current status of our understanding of RNA, with particular emphasis on the chemistry of this key biological molecule. The various RNAs covered are messenger RNA, ribosomal RNA, transfer RNA and RNA enzymes (ribozymes). The different chapters detail biophysical and chemical methods to investigate RNA structure and function, the synthesis of native and modified RNAs and the latest advances in our understanding of the vast array of biological processes in which RNA is involved.

RNA. --- Biochemical genetics. --- Chemical genetics --- Biochemistry --- Molecular genetics --- Ribonucleic acid --- Ribose nucleic acid --- Nucleic acids --- Ribose --- RNA --- ARN --- ELSEVIER-B EPUB-LIV-FT

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The large potential of RNA sequencing and other ""omics"" techniques has contributed to the production of a huge amount of data pursuing to answer many different questions that surround the science's great unknowns. This book presents an overview about powerful and cost-efficient methods for a comprehensive analysis of RNA-Seq data, introducing and revising advanced concepts in data analysis using the most current algorithms. A holistic view about the entire context where transcriptome is inserted is also discussed here encompassing biological areas with remarkable technological advances in the study of systems biology, from microorganisms to precision medicine.

Genetics. --- RNA. --- Access Research Network. --- Ribonucleic acid --- Ribose nucleic acid --- Nucleic acids --- Ribose --- Biology --- Embryology --- Mendel's law --- Adaptation (Biology) --- Breeding --- Chromosomes --- Heredity --- Mutation (Biology) --- Variation (Biology) --- ARN --- Life Sciences --- Microbiology --- Genetics and Molecular Biology --- Biochemistry --- Microbial Genetics

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extracellular RNA --- disease biomarkers --- RNA --- RNA. --- Ribonucleic acid --- Ribose nucleic acid --- Nucleic acids --- Ribose --- Gene Products, RNA --- Non-Polyadenylated RNA --- RNA, Non-Polyadenylated --- Ribonucleic Acid --- Acid, Ribonucleic --- Non Polyadenylated RNA --- RNA Gene Products --- RNA, Non Polyadenylated --- Biopolymers --- extracellular rna --- Biology --- Pharmacology. Therapy --- ARN

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This open access volume gathers a variety of models, delivery systems, and approaches that can be used to assess RNA technology for exploiting antisense as a therapeutic intervention. Beginning with a section on the design of antisense technology and their delivery, the book continues by covering model systems developed to evaluate efficacy, both in vivo and in vitro, as well as methods to evaluate preclinically the toxicity associated with these new potential drugs, and intellectual property considerations. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Antisense RNA Design, Delivery, and Analysis provides basic knowledge and a large collection of methods to facilitate the work of newcomers to this vibrant and expanding field. This book was conceived thanks to the network DARTER (Delivery of Antisense RNA Therapeutics). DARTER is funded by the EU Cooperation of Science and Technology (COST), which aims to enhance interaction and collaborations between researchers in Europe and other countries.

Therapeutics. --- Biomaterials. --- Nucleic acids. --- Nucleic Acid. --- Polynucleotides --- Biomolecules --- Medical treatment --- Therapy --- Treatment of diseases --- Treatments for diseases --- Clinical medicine --- RNA therapeutics --- Antisense technology --- Therapeutic design --- Oligonucleotides --- Model systems --- Oligonucleotide-mediated toxicology --- Open Access --- Àcids nuclèics --- RNA --- Teràpia genètica --- Teràpia gènica --- Terapèutica genètica --- Enginyeria genètica --- Terapèutica --- Àcid ribonucleic --- ARN --- Àcids nucleics --- Micro RNAs --- Biomolècules --- ADN --- Nucleoproteïnes --- Transformació genètica

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Divided into two major sections, this volume synthesizes recent findings in this fast-moving field while also reviewing accepted knowledge. The first part focuses on the antiviral signaling pathways in the host, including specific pattern recognition receptors (PRRs) and how these cellular alarms signal the innate immune response. The second section examines the ways in which specific major RNA virus families interact with, activate, and elude these signaling pathways and responses.

RNA viruses. --- Natural immunity. --- Cellular signal transduction. --- Virus diseases --- Cellular information transduction --- Information transduction, Cellular --- Signal transduction, Cellular --- Bioenergetics --- Cellular control mechanisms --- Information theory in biology --- Disease resistance --- Host resistance --- Innate immunity --- Innate resistance --- Native immunity --- Natural resistance --- Nonspecific immunity --- Resistance to disease --- Immunity --- Riboviruses --- Viruses, RNA --- Viruses --- Immunological aspects. --- RNA Viruses --- Immunity, Innate --- Signal Transduction --- Virus à ARN --- Immunité naturelle --- Transduction du signal cellulaire --- Maladies à virus --- immunology. --- Immunologie