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The LNCS journal Transactions on Large-Scale Data- and Knowledge-Centered Systems focuses on data management, knowledge discovery, and knowledge processing, which are core and hot topics in computer science. Since the 1990s, the Internet has become the main driving force behind application development in all domains. An increase in the demand for resource sharing across different sites connected through networks has led to an evolution of data- and knowledge-management systems from centralized systems to decentralized systems enabling large-scale distributed applications providing high scalability. Current decentralized systems still focus on data and knowledge as their main resource. Feasibility of these systems relies basically on P2P (peer-to-peer) techniques and the support of agent systems with scaling and decentralized control. Synergy between grids, P2P systems, and agent technologies is the key to data- and knowledge-centered systems in large-scale environments. This, the 37th issue of Transactions on Large-Scale Data- and Knowledge-Centered Systems, contains five revised selected regular papers. Topics covered include data security in clouds, privacy languages, probabilistic modeling in linked data integration, business intelligence based on multi-agent systems, and collaborative filtering and prediction accuracy.

Computer science. --- Computer communication systems. --- Software engineering. --- Operating systems (Computers). --- Computer security. --- Data mining. --- Artificial intelligence. --- Computer Science. --- Systems and Data Security. --- Software Engineering. --- Operating Systems. --- Data Mining and Knowledge Discovery. --- Computer Communication Networks. --- Artificial Intelligence (incl. Robotics). --- Artificial Intelligence. --- AI (Artificial intelligence) --- Artificial thinking --- Electronic brains --- Intellectronics --- Intelligence, Artificial --- Intelligent machines --- Machine intelligence --- Thinking, Artificial --- Bionics --- Cognitive science --- Digital computer simulation --- Electronic data processing --- Logic machines --- Machine theory --- Self-organizing systems --- Simulation methods --- Fifth generation computers --- Neural computers --- Algorithmic knowledge discovery --- Factual data analysis --- KDD (Information retrieval) --- Knowledge discovery in data --- Knowledge discovery in databases --- Mining, Data --- Database searching --- Computer privacy --- Computer system security --- Computer systems --- Computers --- Cyber security --- Cybersecurity --- Electronic digital computers --- Protection of computer systems --- Security of computer systems --- Data protection --- Security systems --- Hacking --- Computer operating systems --- Disk operating systems --- Systems software --- Computer software engineering --- Engineering --- Protection --- Security measures --- Operating systems --- Operating systems (Computers) --- Communication systems, Computer --- Computer communication systems --- Data networks, Computer --- ECNs (Electronic communication networks) --- Electronic communication networks --- Networks, Computer --- Teleprocessing networks --- Data transmission systems --- Digital communications --- Electronic systems --- Information networks --- Telecommunication --- Cyberinfrastructure --- Network computers --- Distributed processing

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This book introduces fundamental principles and practical application of techniques used in the scalable production of biopharmaceuticals with animal cell cultures. A broad spectrum of subjects relevant to biologics production and manufacturing are reviewed, including the generation of robust cell lines, a survey of functional genomics for a better understanding of cell lines and processes, as well as advances in regulatory compliant upstream and downstream development. The book is an essential reference for all those interested in translational animal cell-based pharmaceutical biotechnology.

Animal cell biotechnology. --- Pharmaceutical biotechnology. --- Biopharmaceutical technology --- Drugs --- Biotechnology --- Pharmaceutical technology --- Animal cells in biotechnology --- Animal biotechnology --- Biologics Manufacturing. --- Biopharmaceutical Engineering. --- Biotechnology. --- Cell Culture Engineering. --- Virus Production.

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This volume contains the papers which were selected for oral presentation at the first Bioinformatics Research and Development (BIRD) conference held in Berlin, Germany during March 12-14, 2007. BIRD covers a wide range of topics related to bioinformatics like microarray data, genomics, single nucleotide polymorphism, sequence analysis, systems biology, medical applications, proteomics, information systems. The conference was very competitive. From about 140 submissions only 36 were selected by the Program Committee for oral presentation at BIRD and for publication in these proceedings. The acceptance rate was 1/4. The decisions of the Program Committee were guided by the recommendations of several reviewers for each paper. It should be mentioned that these proceedings have companion proceedings published by the Austrian Computer Society where selected poster presentations of the BIRD conference are included. The invited talk titled "From Flies to Human Disease" by Josef Penninger, one of the leading researcher in genetic experiments for investigating disease pathogenesis, was very inspiring and gave new insights into future bioinformatics challenges.

Bioinformatics --- Biological systems --- Computational biology --- Proteomics --- Bio-informatique --- Protéomique --- Congresses. --- Research --- Data processing --- Congrès --- Congresses --- Publication Formats --- Genetics --- Biology --- Investigative Techniques --- Sequence Analysis --- Biochemistry --- Methods --- Computational Biology --- Genomics --- Sequence Analysis, DNA --- Biological Science Disciplines --- Genetic Techniques --- Publication Characteristics --- Chemistry --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Natural Science Disciplines --- Disciplines and Occupations --- Biology - General --- Health & Biological Sciences --- Biosystems --- Systems, Biological --- Bio-informatics --- Biological informatics --- Life sciences. --- Mathematical statistics. --- Data mining. --- Information storage and retrieval. --- Artificial intelligence. --- Bioinformatics. --- Life Sciences. --- Life Sciences, general. --- Computational Biology/Bioinformatics. --- Data Mining and Knowledge Discovery. --- Artificial Intelligence (incl. Robotics). --- Information Storage and Retrieval. --- Probability and Statistics in Computer Science. --- Information science --- Systems biology --- AI (Artificial intelligence) --- Artificial thinking --- Electronic brains --- Intellectronics --- Intelligence, Artificial --- Intelligent machines --- Machine intelligence --- Thinking, Artificial --- Bionics --- Cognitive science --- Digital computer simulation --- Electronic data processing --- Logic machines --- Machine theory --- Self-organizing systems --- Simulation methods --- Fifth generation computers --- Neural computers --- Algorithmic knowledge discovery --- Factual data analysis --- KDD (Information retrieval) --- Knowledge discovery in data --- Knowledge discovery in databases --- Mining, Data --- Database searching --- Mathematics --- Statistical inference --- Statistics, Mathematical --- Statistics --- Probabilities --- Sampling (Statistics) --- Biosciences --- Sciences, Life --- Science --- Statistical methods --- Molecular biology --- Proteins --- System theory --- Philosophy --- Information storage and retrieva. --- Computer science. --- Artificial Intelligence. --- Informatics --- Information storage and retrieval systems. --- Automatic data storage --- Automatic information retrieval --- Automation in documentation --- Computer-based information systems --- Data processing systems --- Data storage and retrieval systems --- Discovery systems, Information --- Information discovery systems --- Information processing systems --- Information retrieval systems --- Machine data storage and retrieval --- Mechanized information storage and retrieval systems --- Computer systems --- Electronic information resources --- Data libraries --- Digital libraries --- Information organization --- Information retrieval --- Computer science—Mathematics. --- Computational and Systems Biology. --- Data centers

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The LNCS journal Transactions on Large-Scale Data- and Knowledge-Centered Systems focuses on data management, knowledge discovery, and knowledge processing, which are core and hot topics in computer science. Since the 1990s, the Internet has become the main driving force behind applicational development in all domains. An increase in the demand for resource sharing across different sites connected through networks has led to an evolvement of data- and knowledge-management systems from centralized systems to decentralized systems enabling large-scale distributed applications providing high scalability. Current decentralized systems still focus on data and knowledge as their main resource. Feasibility of these systems relies basically on P2P (peer-to-peer) techniques and the support of agent systems with scaling and decentralized control. Synergy between Grids, P2P systems, and agent technologies is the key to data- and knowledge-centered systems in large-scale environments. This, the inaugural issue of Transactions on Large-Scale Data- and Knowledge-Centered Systems, consists of journal versions of talks invited to the DEXA 2009 conference and further invited contributions by well-known scientists in the field. Therefore, the content of this issue covers a wide range of different topics in the area of the title of this new journal.

Transaction systems (Computer systems) --- Database management --- Expert systems (Computer science) --- Peer-to-peer architecture (Computer networks) --- Computer Science --- Engineering & Applied Sciences --- Database management. --- P2P (Computer network architecture) --- Knowledge-based systems (Computer science) --- Systems, Expert (Computer science) --- Data base management --- Data services (Database management) --- Database management services --- DBMS (Computer science) --- Generalized data management systems --- Services, Database management --- Systems, Database management --- Systems, Generalized database management --- TP systems (Computer systems) --- Transaction-oriented systems (Computer systems) --- Transaction processing systems (Computer systems) --- Computer science. --- Computer communication systems. --- Computers. --- Data mining. --- Information storage and retrieval. --- Computer Science. --- Computer Communication Networks. --- Database Management. --- Data Mining and Knowledge Discovery. --- Information Storage and Retrieval. --- Information Systems Applications (incl. Internet). --- Information Systems and Communication Service. --- Electronic data processing --- Algorithmic knowledge discovery --- Factual data analysis --- KDD (Information retrieval) --- Knowledge discovery in data --- Knowledge discovery in databases --- Mining, Data --- Database searching --- Automatic computers --- Automatic data processors --- Computer hardware --- Computing machines (Computers) --- Electronic brains --- Electronic calculating-machines --- Electronic computers --- Hardware, Computer --- Computer systems --- Cybernetics --- Machine theory --- Calculators --- Cyberspace --- Communication systems, Computer --- Computer communication systems --- Data networks, Computer --- ECNs (Electronic communication networks) --- Electronic communication networks --- Networks, Computer --- Teleprocessing networks --- Data transmission systems --- Digital communications --- Electronic systems --- Information networks --- Telecommunication --- Cyberinfrastructure --- Network computers --- Informatics --- Science --- Distributed processing --- Computer network architectures --- Real-time data processing --- Artificial intelligence --- Soft computing --- Information storage and retrieva. --- Information systems. --- Information storage and retrieval systems. --- Automatic data storage --- Automatic information retrieval --- Automation in documentation --- Computer-based information systems --- Data processing systems --- Data storage and retrieval systems --- Discovery systems, Information --- Information discovery systems --- Information processing systems --- Information retrieval systems --- Machine data storage and retrieval --- Mechanized information storage and retrieval systems --- Electronic information resources --- Data libraries --- Digital libraries --- Information organization --- Information retrieval --- Application software. --- Application computer programs --- Application computer software --- Applications software --- Apps (Computer software) --- Computer software

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The LNCS journal Transactions on Large-Scale Data- and Knowledge-Centered Systems focuses on data management, knowledge discovery, and knowledge processing, which are core and hot topics in computer science. Since the 1990s, the Internet has become the main driving force behind application development in all domains. An increase in the demand for resource sharing across different sites connected through networks has led to an evolution of data- and knowledge-management systems from centralized systems to decentralized systems enabling large-scale distributed applications providing high scalability. Current decentralized systems still focus on data and knowledge as their main resource. Feasibility of these systems relies basically on P2P (peer-to-peer) techniques and the support of agent systems with scaling and decentralized control. Synergy between grids, P2P systems, and agent technologies is the key to data- and knowledge-centered systems in large-scale environments. This, the 22nd issue of Transactions on Large-Scale Data- and Knowledge-Centered Systems, contains six revised selected regular papers. Topics covered include algorithms for large-scale private analysis, modelling of entities from social and digital worlds and their relations, querying virtual security views of XML data, recommendation approaches using diversity-based clustering scores, hypothesis discovery, and data aggregation techniques in sensor netwo rk environments.

Computer Science --- Engineering & Applied Sciences --- Computer science. --- Mathematical logic. --- Database management. --- Data mining. --- Information storage and retrieval. --- Artificial intelligence. --- Computer Science. --- Information Storage and Retrieval. --- Database Management. --- Artificial Intelligence (incl. Robotics). --- Information Systems Applications (incl. Internet). --- Data Mining and Knowledge Discovery. --- Mathematical Logic and Formal Languages. --- AI (Artificial intelligence) --- Artificial thinking --- Electronic brains --- Intellectronics --- Intelligence, Artificial --- Intelligent machines --- Machine intelligence --- Thinking, Artificial --- Bionics --- Cognitive science --- Digital computer simulation --- Electronic data processing --- Logic machines --- Machine theory --- Self-organizing systems --- Simulation methods --- Fifth generation computers --- Neural computers --- Algorithmic knowledge discovery --- Factual data analysis --- KDD (Information retrieval) --- Knowledge discovery in data --- Knowledge discovery in databases --- Mining, Data --- Database searching --- Data base management --- Data services (Database management) --- Database management services --- DBMS (Computer science) --- Generalized data management systems --- Services, Database management --- Systems, Database management --- Systems, Generalized database management --- Algebra of logic --- Logic, Universal --- Mathematical logic --- Symbolic and mathematical logic --- Symbolic logic --- Mathematics --- Algebra, Abstract --- Metamathematics --- Set theory --- Syllogism --- Informatics --- Science --- Information storage and retrieva. --- Artificial Intelligence. --- Information storage and retrieval systems. --- Automatic data storage --- Automatic information retrieval --- Automation in documentation --- Computer-based information systems --- Data processing systems --- Data storage and retrieval systems --- Discovery systems, Information --- Information discovery systems --- Information processing systems --- Information retrieval systems --- Machine data storage and retrieval --- Mechanized information storage and retrieval systems --- Computer systems --- Electronic information resources --- Data libraries --- Digital libraries --- Information organization --- Information retrieval --- Application software. --- Application computer programs --- Application computer software --- Applications software --- Apps (Computer software) --- Computer software