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Pathophysiological states, neurological and psychiatric diseases are almost universally considered from the neurocentric point of view, with neurons being the principal cellular element of pathological process. The brain homeostasis, which lies at the fulcrum of healthy brain function, the compromise of which invariably results in dysfunction/disease, however, is entirely controlled by neuroglia. It is becoming clear that neuroglial cells are involved in various aspects of initiation, progression and resolution of neuropathology.  In this book we aim to integrate the body of information that has accumulated in recent years revealing the active role of glia in such pathophysiological processes.  Understanding roles of glial cells in pathology will provide new targets for medical intervention and aide the development of much needed therapeutics. This book will be particularly useful for researchers, students, physicians and psychotherapists working in the field of neurobiology, neurology and psychiatry.

Neuroglia. --- Nervous system --- Diseases. --- Medical neurology --- Nerves --- Neurologic disorders --- Neurological disorders --- Neuropathology --- Neurology --- Glial cells --- Nerve tissue --- Diseases --- Neurosciences. --- Neurochemistry. --- Neurology. --- Psychiatry. --- Neural sciences --- Neurological sciences --- Neuroscience --- Medical sciences --- Medicine and psychology --- Mental health --- Psychology, Pathological --- Medicine --- Neuropsychiatry --- Biochemistry --- Neurosciences --- Neurology .

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Due to their lack of electrical excitability, astrocytes, a subtype of glial cell, have long been neglected as active participants in intercellular communication within the central nervous system. Astrocytes, however, possess a diverse assortment of ion channels, neurotransmitter receptors, and transport mechanisms that enable them to respond to many of the same signals that act on neurons. Astrocytes in (Patho)Physiology of the Nervous System provides readers with a comprehensive description of the physiological roles astrocytes play in regulating neuronal activity and their critical involvement in pathophysiological states of the nervous system, including gliomas, Alexander's disease, and epilepsy. This book will be particularly useful for researchers, students, and workers in the field of neurobiology and cell biology. About the authors: Vladimir Parpura, M.D., Ph.D holds both a medical degree, awarded from the University of Zagreb in Croatia in 1989, and a doctorate, received in Neuroscience and Zoology from Iowa State University in 1993. He has held faculty appointments at the Department of Zoology and Genetics, Iowa State University and the Department of Cell Biology and Neuroscience, University of California Riverside. He is presently an Associate Professor in the Department of Neurobiology, University of Alabama Birmingham. His current research focuses on understanding the modulation of calcium-dependent glutamate release from astrocytes. Philip G. Haydon, Ph.D received his doctorate from the University of Leeds, England in 1982. He has held faculty appointments at the Department of Zoology and Genetics, Iowa State University, the Department of Neuroscience at the University of Pennsylvania, and has recently moved to Tufts University School of Medicine as Professor and Chair of the Department of Neuroscience. His research focuses on the role of astrocytes in the regulation of synapses, neuronal networks and behavior as well as how these glial cells contribute to neurological disorders.

Cytology. --- Neurobiology. --- Neurosciences. --- Astrocytes --- Nervous system --- Biological Science Disciplines --- Neuroglia --- Nervous System --- Natural Science Disciplines --- Anatomy --- Cells --- Disciplines and Occupations --- Physiology --- Central Nervous System --- Medicine --- Human Anatomy & Physiology --- Health & Biological Sciences --- Neuroscience --- Neurology --- Pathophysiology --- Cytopathology --- Astrocytes. --- Cytopathology. --- Pathophysiology. --- Glia (Neurology) --- Medicine. --- Cell biology. --- Biomedicine. --- Cell Biology. --- Organs (Anatomy) --- Neurosciences --- Cell biology --- Cellular biology --- Biology --- Cytologists --- Neural sciences --- Neurological sciences --- Medical sciences

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This book provides a comprehensive overview of the role of neuroglia in neurodegenerative diseases. Neuroglia are the most abundant cells in the nervous system and consist of several distinct cell types, such as astrocytes, oligodendrocytes,and microglia. Accumulating evidence suggests that neuroglia participate in the neurodegenerative process, and as such are essential players in a variety of diseases, including Alzheimer’s, Parkinson’s, and Huntington’s. Intended for researchers and students, the book presents recent advances concerning the biology of neuroglia as well as their interaction with neurons during disease progression. In addition, to highlight the function of neuroglia in different types of neurodegenerative disease, it also discusses their mechanisms and effects on protecting or damaging neurons.

Nervous system --- Degeneration, Nerve --- Nerve degeneration --- Nervous system degeneration --- Neurodegenerative disease --- Neurodegenerative diseases --- Neurodegenerative disorders --- Neuron degeneration --- Nissl degeneration --- Retrograde degeneration --- Wallerian degeneration --- Degeneration (Pathology) --- Degeneration. --- Degeneration and regeneration --- Neurosciences. --- Neurology . --- Molecular biology. --- Neurology. --- Molecular Medicine. --- Molecular biochemistry --- Molecular biophysics --- Biochemistry --- Biophysics --- Biomolecules --- Systems biology --- Medicine --- Neuropsychiatry --- Neural sciences --- Neurological sciences --- Neuroscience --- Medical sciences --- Diseases