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Papers related to any fields of medicine that present an interdisciplinary dimension.

internal medicine --- clinical and preclinical research --- progress in medicine --- Medicine --- Medicine. --- Europe. --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Council of Europe countries --- Eastern Hemisphere --- Eurasia --- Human medicine --- Health Workforce --- Medicine - General

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This Open Access book is a guide to good, responsible research at each step of the process of research discovery, so that a researcher at the beginning of a scientific career has a clear pathway to doing good research and producing reliable results. The textbook will give context to the practices described in the European Code of Conduct for Research Integrity, guided by the fundamental principles or research integrity – reliability, honesty, respect, and accountability. The chapters in the book follow the good practices outlined in the Code, give practical advice and address basic principles. In this way, the book is applicable to different research fields. It directs readers to various sources for further and updated information, particularly drawing from the resources available at The Embassy of Good Science, the European platform for research integrity and ethics.

Medicine—Research. --- Biology—Research. --- Clinical medicine—Research. --- Medical sciences. --- Drug development. --- Bioethics. --- Medical Ethics. --- Biomedical Research. --- Clinical Research. --- Preclinical Research. --- Biomedical ethics --- Clinical ethics --- Ethics, Medical --- Health care ethics --- Medical care --- Medicine --- Bioethics --- Professional ethics --- Nursing ethics --- Social medicine --- Biology --- Life sciences --- Life sciences ethics --- Science --- Development of drugs --- Drugs --- New drug development --- Pharmacology --- Pharmacy --- Basic medical sciences --- Basic sciences, Medical --- Biomedical sciences --- Health sciences --- Preclinical sciences --- Sciences, Medical --- Moral and ethical aspects --- Development --- Research --- Moral and ethical aspects.

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This up-to-date and unique monograph covers the different aspects of pharmaceutical validation, calibration, qualification and documentation. It discusses the various methods and processes under all these heads. It includes eight major sections and exhaustively covers each topic.The book includes interesting and timely topics like the ‘Validation of herbals’ considering the increasing reliance on herbal medicines. It includes a section of validation of dosage forms, which is an essential topic for any pharmaceutical scientist. The chapters provide lucid illustrations, figures, flowcharts and other diagrams to facilitate understanding. A final section on 'expert opinion' provides a rundown about the global scenario to the readers. The book serves as a complete reference material for students, researchers and industry experts in the field of pharmaceutical sciences, medicinal chemistry and pharmacology.

Pharmacy. --- Pharmacology. --- Medical sciences. --- Drug development. --- Pharmaceutical chemistry. --- Toxicology. --- Pharmacovigilance. --- Preclinical Research. --- Pharmaceutics. --- Drug Safety and Pharmacovigilance. --- Pharmacoepidemiology --- Chemicals --- Medicine --- Pharmacology --- Poisoning --- Poisons --- Chemistry, Medical and pharmaceutical --- Chemistry, Pharmaceutical --- Drug chemistry --- Drugs --- Medical chemistry --- Medicinal chemistry --- Pharmacochemistry --- Chemistry --- Development of drugs --- New drug development --- Pharmacy --- Basic medical sciences --- Basic sciences, Medical --- Biomedical sciences --- Health sciences --- Preclinical sciences --- Sciences, Medical --- Life sciences --- Drug effects --- Medical pharmacology --- Medical sciences --- Chemotherapy --- Materia medica --- Toxicology --- Development --- Physiological effect --- Calibration. --- Pharmaceutical technology Quality control. --- Pharmaceutical technology Standards. --- Physical measurements --- Standardization

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This book provides an overview of Data Monitoring Committees - what was done in the past, what is currently being done, and thoughts on improvements for the future. Previous works focused primarily on large cardiovascular studies (where DMCs originated more than 30 years ago) but updated references are needed that discuss smaller, more flexible studies in areas such as oncology. The authors have attended ~800 DMC meetings from ~200 distinct studies across all areas of clinical studies (oncology, rheumatology, rare diseases, cardiology, immunology, etc.) This wide range of expertise will be used, as well as the expertise that comes from working with virtually every large biotech/pharma and CRO for DMC work. The reader of the book will know when DMCs are needed or helpful, how to form the DMC, how to work with external CROs and with sponsor teams and the DMC to create needed DMC outputs, how the DMC meetings are conducted, and - especially for DMC members - what are considerations within the Closed Session to review safety/efficacy outputs to assess risk/benefit to make appropriate recommendations that protect the patient safety and trial integrity. This is a practical hands-on book on how to decide if a DMC is necessary, how to form the DMC, how to smoothly create the necessary materials for the DMC and have smooth running DMC meetings. There is no specialized training in school about how DMCs work - frequently people may have been in industry for many years without ever needing to work with a DMC. This book is the helpful reference for those new to these DMCs. The DMC work is critical to be correctly implemented as the implications of it are so great. This book provides the following: Thorough instructions on the steps needed to form and implement a Data Monitoring Committee for clinical trial evaluation; Includes practical and hands-on information on DMC implementation; Discusses a wide range of clinical trial – by phase and therapeutic area.

Pharmacology. --- Medical sciences. --- Drug development. --- Medicine—Research. --- Biology—Research. --- Pharmaceutical chemistry. --- Biometry. --- Toxicology. --- Preclinical Research. --- Biomedical Research. --- Pharmaceutics. --- Biostatistics. --- Medical Toxicology. --- Biological statistics --- Biology --- Biometrics (Biology) --- Biostatistics --- Biomathematics --- Statistics --- Chemistry, Medical and pharmaceutical --- Chemistry, Pharmaceutical --- Drug chemistry --- Drugs --- Medical chemistry --- Medicinal chemistry --- Pharmacochemistry --- Chemistry --- Development of drugs --- New drug development --- Pharmacology --- Pharmacy --- Basic medical sciences --- Basic sciences, Medical --- Biomedical sciences --- Health sciences --- Preclinical sciences --- Sciences, Medical --- Life sciences --- Medicine --- Drug effects --- Medical pharmacology --- Medical sciences --- Chemicals --- Chemotherapy --- Poisoning --- Poisons --- Statistical methods --- Development --- Physiological effect --- Toxicology

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This Open Access volume provides readers with an open access protocol collection and wide-ranging recommendations for preclinical renal MRI used in translational research. The chapters in this book are interdisciplinary in nature and bridge the gaps between physics, physiology, and medicine. They are designed to enhance training in renal MRI sciences and improve the reproducibility of renal imaging research. Chapters provide guidance for exploring, using and developing small animal renal MRI in your laboratory as a unique tool for advanced in vivo phenotyping, diagnostic imaging, and research into potential new therapies. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and thorough, Preclinical MRI of the Kidney: Methods and Protocols is a valuable resource and will be of importance to anyone interested in the preclinical aspect of renal and cardiorenal diseases in the fields of physiology, nephrology, radiology, and cardiology. This publication is based upon work from COST Action PARENCHIMA, supported by European Cooperation in Science and Technology (COST). COST (www.cost.eu) is a funding agency for research and innovation networks. COST Actions help connect research initiatives across Europe and enable scientists to grow their ideas by sharing them with their peers. This boosts their research, career and innovation. PARENCHIMA (renalmri.org) is a community-driven Action in the COST program of the European Union, which unites more than 200 experts in renal MRI from 30 countries with the aim to improve the reproducibility and standardization of renal MRI biomarkers.

Ronyó --- Ressonància magnètica --- Àtoms --- Spin (Física nuclear) --- Ressonància magnètica nuclear --- Ressonància paramagnètica electrònica --- Relaxació magnètica --- Ronyons --- Abdomen --- Aparell urinari --- Diüresi --- Glàndules suprarenals --- Malalties del ronyó --- Nefrologia --- Analytical chemistry. --- Biology—Technique. --- Radiology. --- Physiology. --- Medicine—Research. --- Biology—Research. --- Analytical Chemistry. --- Biological Techniques. --- Biomedical Research. --- Radiological physics --- Physics --- Radiation --- Analysis, Chemical --- Analytic chemistry --- Chemical analysis --- Chemistry, Analytic --- Chemistry --- Animal physiology --- Animals --- Biology --- Anatomy --- Physiology --- Analytical Chemistry --- Biological Techniques --- Imaging / Radiology --- Biomedicine, general --- Biological Imaging --- Radiology --- Renal Physiology --- Preclinical Research --- renal pathophysiology --- diabetic nephropathy --- circadian rhythm --- Magnetic field strength --- Radio frequency coils --- NCMRA --- CEMRA --- Open Access --- Biology, life sciences --- Scientific equipment, experiments & techniques --- Medical imaging --- Life sciences: general issues --- Medical research --- Fisiologia humana --- Imatges per ressonància magnètica --- Diagnòstic per ressonància magnètica nuclear --- IRM --- MR Imaging --- MRI --- Tomografia per ressonància magnètica nuclear --- Diagnòstic per la imatge --- Biologia humana --- Ciències de la salut --- Fisiologia --- Mecànica humana --- Reproducció humana --- Cos humà