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Sentinel lymph node (SLN) procedures have opened a window of opportunity for the study of micrometastasis. In eighty percent (80%) of metastasis there lies an orderly pattern of progression via the lymphatic network, while 20% of the time systemic metastasis occurs, bypassing the lymphatic system. During the past two decades, significant progress has been achieved in understanding the anatomical, functional, cellular and molecular aspects of the lymphovascular system and the metastasis process. · Molecular imaging advances help to localize early cancers more precisely. · Current status of the immune responses in the draining lymph nodes against cancer is summarized. · New paradigms of early cancer growth, proliferation, overcoming apoptosis are exploited in the development of anticancer treatment. In this book, basic scientists and clinicians exchange ideas so that laboratory findings can be applied to clinical dilemmas, and clinical problems can be targeted for research in the laboratory. Series editor's comments: "Cancer metastasis remains the greatest challenge for oncologists. The role of the lymphovascular system is critical and a focus of intense investigations. This text covers a spectrum of relevant research and clinical issues that impact on our understanding of this process." Steven T. Rosen, MD Series Editor.

Lymphatic metastasis. --- Lymphatics --- Metastasis --- Cancer --- Oncology  . --- Hematology. --- Internal medicine. --- Oncology. --- Internal Medicine. --- Medicine, Internal --- Medicine --- Haematology --- Internal medicine --- Blood --- Tumors --- Diseases

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In human solid tumors, nodal status is the most important prognostic indicator for patient outcome. Recent developments in the sentinel lymph node concept have resulted in new procedures to define the first draining node as the primary gateway through which the cancer will spread. In From Local Invasion to Metastatic Cancer: Involvement of Distant Sites Through the Lymphovascular System, a panel of international authorities takes an in-depth look at the role of the lymphovascular system in the spread of cancer. The authors summarize the findings of the Second International Symposium on Cancer Metastasis: Basis for Rational Therapy summit. Specifically, the book presents important developments in the biology and clinical understanding of cancer metastasis, describes the relationship between tumor microenvironment and proliferation, and defines the process of lymphangiogenesis and angiogenesis with special reference to cancer metastasis. From Local Invasion to Metastatic Cancer: Involvement of Distant Sites Through the Lymphovascular System provides oncologists, radiologists, and cancer researchers the necessary information to study and develop new strategies to curb the process of metastasis.

Lymphatic Metastasis -- Congresses. --- Metastasis. --- Oncology --- Medicine --- Health & Biological Sciences --- Metastasis --- Lymphangiogenesis --- Congresses --- Neovascularization, Pathologic --- Neoplasm Invasiveness --- Antineoplastic Combined Chemotherapy Protocols --- Lymphatic Metastasis --- Organogenesis --- Neoplasm Metastasis --- Publication Formats --- Antineoplastic Protocols --- Neoplastic Processes --- Metaplasia --- Drug Therapy, Combination --- Pathologic Processes --- Embryonic and Fetal Development --- Clinical Protocols --- Publication Characteristics --- Neoplasms --- Drug Therapy --- Morphogenesis --- Therapeutics --- Pathological Conditions, Signs and Symptoms --- Diseases --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Growth and Development --- Physiological Processes --- Physiological Phenomena --- Phenomena and Processes --- Lymphatic metastasis. --- Oncology. --- Medicine. --- Radiotherapy. --- Pathology. --- Surgical oncology. --- Medicine & Public Health. --- Surgical Oncology. --- Tumors --- Lymphatics --- Cancer --- Oncology  . --- Disease (Pathology) --- Medical sciences --- Medicine, Preventive --- Radiation therapy --- Electrotherapeutics --- Hospitals --- Medical electronics --- Medical radiology --- Therapeutics, Physiological --- Phototherapy --- Oncologic surgery --- Oncological surgery --- Surgical oncology --- Radiological services --- Excision --- Treatment --- Cancer metastasis --- Lymphovascular system

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The sentinel lymph node concept is meeting with steadily growing interest and is being extended to the different sites of the primaries. In addition, the concept is being applied in an increasingly sophisticated manner. In this book the practical application of the sentinel node concept is evaluated from the points of view of pathology, radiodiagnosis and nuclear medicine diagnostics, surgical treatment and clinical oncology. The concept is analyzed for breast cancer, malignant melanoma, tumors of the face, oropharynx, lung, gastrointestinal and urogenital tract. The first part of the book describes the function and use of the nuclear medicine equipment, the tracers used, colloid solutions and modern developments in histological and immunohistochemical lymph node investigations, as well as possible pitfalls. The consequences of false-negative results are clearly delineated. In the second part, specific tumor-related problems are described.

Lymphatic metastasis --- Lymphatics --- Diagnosis. --- Cancer. --- Metastasis --- Cancer --- Hematology. --- Nuclear medicine. --- Pathology. --- Surgery. --- Gynecology. --- Nuclear Medicine. --- Gynaecology --- Medicine --- Generative organs, Female --- Surgery, Primitive --- Disease (Pathology) --- Medical sciences --- Diseases --- Medicine, Preventive --- Atomic medicine --- Radioisotopes in medicine --- Medical radiology --- Radioactive tracers --- Radioactivity --- Haematology --- Internal medicine --- Blood --- Physiological effect --- Gynecology .

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Lymphoscintigraphy is now widely applied for radioguided biopsy of the sentinel lymph node in patients with solid cancers and is considered crucial for adequate planning of oncologic surgery in a growing number of cancers. This atlas presents a collection of richly illustrated teaching cases that demonstrate the clinical relevance and impact of lymphoscintigraphy in different pathologic conditions. The principal focus is on the use of lymphoscintigraphic mapping for radioguided sentinel node biopsy in cutaneous melanoma and cancers at a range of anatomic sites. The most commonly observed lymphoscintigraphic patterns are depicted, and anatomic variants and technical pitfalls of the procedure receive careful attention. The role of tomographic multimodality imaging is also considered. This atlas will be an excellent learning tool for residents in nuclear medicine and other specialists with an interest in the field.

Breast -- Cancer -- Atlases. --- Colon (Anatomy) -- Cancer -- Atlases. --- Lymph nodes -- Dissection -- Atlases. --- Lymphatic metastasis -- Diagnosis -- Atlases. --- Melanoma -- Atlases. --- Tumors -- Classification -- Atlases. --- Lymphatics --- Lymph nodes --- Lymphatic metastasis --- Lymphoid Tissue --- Diagnostic Imaging --- Publication Formats --- Neoplasm Metastasis --- Investigative Techniques --- Biopsy --- Publication Characteristics --- Tissues --- Diagnostic Techniques, Surgical --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Diagnostic Techniques and Procedures --- Neoplastic Processes --- Diagnosis --- Anatomy --- Neoplasms --- Diseases --- Atlases --- Methods --- Radionuclide Imaging --- Lymphatic Metastasis --- Sentinel Lymph Node Biopsy --- Lymph Nodes --- Medicine --- Health & Biological Sciences --- Radiology, MRI, Ultrasonography & Medical Physics --- Radioisotope scanning --- Lymphangiography. --- Imaging. --- Radiography. --- Lymph glands --- Lymph nodules --- Nodes, Lymph --- Nodules, Lymph --- Nodus lymphaticus --- Lymphography --- Lymphatic system --- Radiography --- Medicine. --- Nuclear medicine. --- Angiology. --- Otolaryngologic surgery. --- Minimally invasive surgery. --- Surgical oncology. --- Medicine & Public Health. --- Nuclear Medicine. --- Minimally Invasive Surgery. --- Head and Neck Surgery. --- Surgical Oncology. --- Blood-vessels --- Laparoscopic surgery. --- Diseases. --- Angiography --- Radiography, Medical --- Immune system --- Endoscopic surgery. --- Head --- Angiography. --- Surgery. --- Diagnosis, Radioscopic --- Cancer --- Oncologic surgery --- Oncological surgery --- Surgical oncology --- Endosurgery --- Minimal access surgery --- Minimally invasive surgery --- MIS (Minimally invasive surgery) --- Operative endoscopy --- Surgical endoscopy --- Endoscopy --- Microsurgery --- Surgery, Operative --- Atomic medicine --- Radioisotopes in medicine --- Medical radiology --- Radioactive tracers --- Radioactivity --- Excision --- Treatment --- Physiological effect --- Operative otolaryngology --- Otolaryngologic surgery --- Surgery, Orificial

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This work presents the most advanced discoveries from translational research laboratories directly involved in identifying molecules and signalling pathways that play an instrumental role in metastasis. In contrast to other works, conventionally focused on a single type of tumour, the various chapters in this book provide a broad perspective of the similarities and discrepancies among the dissemination of several solid malignancies. Through recurrent and overlapping references to molecular mechanisms and mediators, the readers will gain knowledge of the common ground in metastasis from a single source. Finally, an introductory chapter provides a clinical perspective of the problems presented by metastatic tumours for diagnosis and treatment. The work presented here is directed to researchers in tumour biology with a developing interest in metastatic dissemination as well as medical and graduate students seeking to expand and integrate the notions acquired in basic cancer biology and oncology courses.

Lymphatic Metastasis. --- Metastasis. --- Neoplasm Metastasis. --- Signal Transduction. --- Metastasis --- Pathologic Processes --- Biochemical Processes --- Cell Physiological Processes --- Neoplasms --- Biological Science Disciplines --- Gene Expression Regulation --- Genetic Processes --- Biochemical Phenomena --- Cell Physiological Phenomena --- Natural Science Disciplines --- Pathological Conditions, Signs and Symptoms --- Chemical Processes --- Diseases --- Chemical Phenomena --- Disciplines and Occupations --- Genetic Phenomena --- Phenomena and Processes --- Gene Expression Regulation, Neoplastic --- Neoplastic Processes --- Neoplasm Metastasis --- Signal Transduction --- Physiology --- Medicine --- Health & Biological Sciences --- Oncology --- Cancer invasiveness. --- Cancer --- Molecular aspects. --- Dissemination of cancer --- Invasiveness (Oncology) --- Neoplasm invasiveness --- Spread of cancer --- Tumor dissemination --- Tumor invasiveness --- Tumor progression --- Tumor spread --- Cancer metastasis --- Metastases --- Metastatic cancer --- Neoplasm metastasis --- Tumor metastasis --- Dissemination --- Medicine. --- Cancer research. --- Medical genetics. --- Oncology. --- Proteins. --- Cytokines. --- Growth factors. --- Biomedicine. --- Cancer Research. --- Gene Function. --- Receptors. --- Cytokines and Growth Factors. --- Cancer cells --- Pathology --- Cancer invasiveness --- Cancer of unknown primary origin --- Growth --- Oncology  . --- Cell receptors. --- Cellular immunity --- Immune response --- Cell membrane receptors --- Cell surface receptors --- Receptors, Cell --- Binding sites (Biochemistry) --- Cell membranes --- Proteins --- Clinical genetics --- Heredity of disease --- Human genetics --- Medical sciences --- Genetic disorders --- Tumors --- Regulation --- Genetic aspects --- Proteins . --- Cell growth factors --- Cellular growth factors --- Growth peptides --- Growth promoting substances --- Growth substances --- Peptide growth factors --- Peptide regulatory factors --- Polypeptide growth factors --- Cytokines --- Peptides --- Proteids --- Biomolecules --- Polypeptides --- Proteomics --- Cancer research