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Cell receptors --- Ligands (Biochemistry) --- Cellular signal transduction --- Receptors, Cell Surface. --- Ligands. --- Signal Transduction. --- Biophysics --- Ligands (Biochimie) --- Transduction du signal cellulaire

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This research topic highlights the most recent accomplishments of a Scientific Committee on Oceanic Research (SCOR) Working Group, SCOR WG 139: Organic Ligands - A Key Control on Trace Metal Biogeochemistry in the Ocean.

trace metals --- ocean chemistry --- organic ligands --- seawater --- chemical speciation

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Since the discovery of crown ethers by Pedersen in 1967, several thousands of crown ethers and analogous compounds have been synthesized. Their specific characteristics have been investigated and a variety of applications developed. These developments have led to new fields of chemistry called host-guest chemistry and supramolecular chemistry. This book presents the state-of-the-art of the chemistry of crown ethers and analogous compounds. The first chapter provides an orientation in the new fields of chemistry. Chapter 2 reviews advances in synthetic procedures for crown ethers and analogous

Crown ethers. --- Macromolecules. --- Molecules --- Supramolecular chemistry --- Macrocyclic polyethers --- Ethers --- Ionophores --- Ligands --- Macrocyclic compounds

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The BLyS/BAFF family of cytokines and receptors has captured and held the attention of B cell biologists during the last decade. Discovery of the two ligands and three receptors comprising this family has yielded a watershed of insights; fostering fresh paradigms in our views about the differentiation, selection, and homeostatic control of virtually all B cell subsets. Moreover, because these processes are intimately tied to the mechanistic underpinnings of immune tolerance and activation, increased understanding of these activities promises translational progress in autoimmunity, neoplasia, and transplantation.

B cells -- Differentiation. --- B cells. --- Cell receptors. --- Ligands (Biochemistry). --- Ligands. --- B cells --- Ligands (Biochemistry) --- Cell receptors --- Membrane Proteins --- Antibody-Producing Cells --- Lymphocytes --- Cell Physiological Processes --- Laboratory Chemicals --- B-Lymphocytes --- Ligands --- Receptors, Cell Surface --- Cell Differentiation --- Cells --- Cell Physiological Phenomena --- Leukocytes, Mononuclear --- Specialty Uses of Chemicals --- Immune System --- Proteins --- Leukocytes --- Phenomena and Processes --- Chemical Actions and Uses --- Hemic and Immune Systems --- Anatomy --- Amino Acids, Peptides, and Proteins --- Blood Cells --- Chemicals and Drugs --- Blood --- Biology --- Microbiology & Immunology --- Health & Biological Sciences --- Differentiation --- Autoimmunity. --- Autoallergy --- B lymphocytes --- Bone marrow derived cells --- Bursa equivalent cells --- Medicine. --- Immunology. --- Microbiology. --- Biomedicine. --- Immunity --- Autoantibodies --- Antigen presenting cells --- Microbial biology --- Microorganisms --- Immunobiology --- Life sciences --- Serology

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European Cooperation in Science and Technology (COST) supports the collaboration of nationally-funded science and technology research through the creation of networks. COST is the longest-running European framework enhancing cooperation among researchers, engineers and scholars across Europe. The COST Action CM1103 “Structure-based drug design for diagnosis and treatment of neurological diseases: dissecting and modulating complex function in the monoaminergic systems of the brain” is a good example of the advances possible through interdisciplinary collaboration on difficult problems. COST Action CM1103 brought together 28 research groups from 18 countries to collaborate for four years on multi-target drug design for complex neuropathologies. The interdisciplinary expertise of the members is spans the range from computational enzymology to human studies, providing outstanding opportunities for the interdisciplinary development of trainees, and is reflected in the articles in this e-book. This Research Topic covers progress in multi-target drug design for the complex neuropathologies of the monoamine system that are apparent, for example, in Alzheimer’s disease. After a mini-review to introduce the topic of multi-target drug design, the other articles review the Research topic from their own perspective, two from computational approaches, three from medicinal chemistry, two from molecular pharmacology, and two from studies in whole brain. This multi-faceted approach describes new compounds, new methodology, and advances in the basic science of understanding the brain. This Ebook is based upon work from COST Action (CM1103 “Structure-based drug design for diagnosis and treatment of neurological diseases: dissecting and modulating complex function in the monoaminergic systems of the brain"), supported by COST (European Cooperation in Science and Technology). COST (European Cooperation in Science and Technology) is a pan-European intergovernmental framework. Its mission is to enable break-through scientific and technological developments leading to new concepts and products and thereby contribute to strengthening Europe’s research and innovation capacities. It allows researchers, engineers and scholars to jointly develop their own ideas and take new initiatives across all fields of science and technology, while promoting multi- and interdisciplinary approaches. COST aims at fostering a better integration of less research intensive countries to the knowledge hubs of the European Research Area. The COST Association, an International not-for-profit Association under Belgian Law, integrates all management, governing and administrative functions necessary for the operation of the framework. The COST Association has currently 36 Member Countries. www.cost.eu

Rationale drug design --- GPCR agonists --- Molecular dynamic simulations --- Neurodegenerative Diseases --- monoamine pharmacology --- Oxidative Stress --- Multi-target designed ligands --- Epilepsy --- Chemi-informatics