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Studies focusing on the perinatal period face unique challenges, yet research in this area is extremely important, as this period of life is highly delicate and adverse events might have a long-lasting impact. With the advent of powerful high-resolution and high-throughput analytical methods, researchers have started to successfully develop and implement novel approaches in this area. New insights have great potential to be translated into novel diagnostic tools, as well as alternative preventive and treatment approaches. This book collects a series of timely review and original research articles focusing on metabolomic, oxidative, and nitrosative stress in the perinatal period.We would like to thank all involved authors for their high-quality contributions and their commitment to the publication of this work and hope that this book will be a useful resource for students, scientists, and doctors working in this specific area of application.

glutathione --- glutamate --- oxidative stress --- hypoxia ischemia --- endotoxin --- magnetic resonance spectroscopy --- N-acetylcysteine --- vitamin D --- neonatal HIE --- MRS --- preterm birth --- sex differences --- male disadvantage --- female advantage --- bronchopulmonary dysplasia --- retinopathy of prematurity --- necrotizing enterocolitis --- intraventricular hemorrhage --- periventricular leukomalacia --- mortality --- transposition of the great arteries --- balloon atrial septostomy --- hypoxemia --- metabolomics --- newborn --- liquid chromatography-mass spectrometry (LC-MS) --- allopurinol --- hypothermia --- hypoxic-ischemic encephalopathy --- oxidative damage --- donor milk --- treatment --- Holder pasteurization --- breastmilk --- preterm --- antioxidant capacity --- asphyxia neonatorum --- non-invasive diagnostics --- saliva --- neonatal hypoxia–ischemia --- kynurenic acid (KYNA) --- neuroprotection --- hyperoxia --- prematurity --- n/a --- neonatal hypoxia-ischemia

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A screenshot of some the most rapidly evolving fields in Neonatology and Pediatrics with articles reviewing some metabolic dysregulations as well as non-oncologic diseases that may occur in infancy, childhood, youth. The illustrative material with original photographs and drawings highlighting some pathogenetic concepts are keystones of this book.

interferon signature score --- interferonopathies --- n/a --- rat model --- pulmonary hypertension --- neurological symptoms --- early-onset sarcoidosis --- sialidosis --- sialidosis I --- children --- mediastinitis --- bilirubin encephalopathy --- Blau syndrome --- myocardial dysfunction --- cardiopulmonary bypass --- neuropathology --- bacteremia --- tissue doppler imaging --- HD-OCT --- biostatistics --- continuous insulin infusion system --- infants --- RNFL --- biomarkers --- diagnosis --- somatosensory evoked potential --- Paediatric sarcoidosis --- diabetic retinopathy --- brain damage --- tonsillectomy --- hybrid closed-loop system --- cytopathology --- neuraminidase --- subcutaneous emphysema --- continuous glucose monitor --- respiratory syncytial virus --- data sharing --- complication --- lysosomal storage disease --- echocardiography --- ONH --- systemic lupus erythematosus --- NT-proBNP --- preterm brain --- head and neck --- inter-laboratory variability --- GSH --- insulin pump --- high-risk sarcoidosis --- type 1 diabetes --- hypoxia-ischemia --- Tei index --- sialidosis II --- mediastinal emphysema --- newborn --- diabetes technology --- diagnostics --- lysosomal exocytosis --- kernicterus --- cerebral palsy --- choroidal thickness --- oxidative stress --- Children --- Pediatrics. --- Diseases. --- Paediatrics --- Pediatric medicine --- Medicine --- Childhood diseases --- Children's diseases --- Diseases of children --- Juvenile diseases --- Pediatrics --- Diseases --- Health and hygiene