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Genetics --- Genomes --- Genome --- Periodicals. --- periodicals. --- Genomics --- Mutation (Biology) --- Génétique --- Génome humain --- Research --- Biology --- Embryology --- Mendel's law --- Adaptation (Biology) --- Breeding --- Chromosomes --- Heredity --- Variation (Biology) --- Genes --- Proteome --- Genetic Structures --- Genetic Phenomena --- Chromosome Aberrations. --- Mutation. --- Abnormalities, Autosome --- Abnormalities, Chromosomal --- Abnormalities, Chromosome --- Chromosomal Aberrations --- Chromosome Abnormalities --- Cytogenetic Abnormalities --- Autosome Abnormalities --- Cytogenetic Aberrations --- Aberration, Chromosomal --- Aberration, Chromosome --- Aberration, Cytogenetic --- Aberrations, Chromosomal --- Aberrations, Chromosome --- Aberrations, Cytogenetic --- Abnormalities, Cytogenetic --- Abnormality, Autosome --- Abnormality, Chromosomal --- Abnormality, Chromosome --- Abnormality, Cytogenetic --- Autosome Abnormality --- Chromosomal Aberration --- Chromosomal Abnormalities --- Chromosomal Abnormality --- Chromosome Aberration --- Chromosome Abnormality --- Cytogenetic Aberration --- Cytogenetic Abnormality --- Cytogenetics --- Genetics, Medical --- Cytogenetic Analysis --- Mutations --- DNA Damage --- Polymorphism, Restriction Fragment Length --- abnormalities
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This issue of Recent Results in Cancer Research presents a comprehensive review of current understanding of chromosomal instability in cancer and of strategies to use this information for better treatment of patients with cancer. Cancer is a disease of the chromosomes, and chromosomal instability in cancer disrupts gene function by either inactivating tumor suppressor genes or activating growth-promoting oncogenes. The chromosomal basis for these aberrations is either translocations, which change the integrity of genes, or abnormal numbers of chromosomes, a condition referred to as aneuploidy, which results in abnormal gene expression levels. Such structural or numerical chromosomal aberrations are specific for distinct tumor entities. The degree of chromosomal instability and the degree of intratumor heterogeneity have profound consequences for disease outcome and for therapeutic stratification.
Gene Expression Regulation, Neoplastic --- Chromosomal Instability --- Translocation, Genetic --- Aneuploidy --- Neoplasms --- Diseases --- Ploidies --- Genomic Instability --- Gene Expression Regulation --- Chromosome Aberrations --- Mutagenesis --- Pathologic Processes --- Mutation --- Genetic Phenomena --- Genetic Processes --- Pathological Conditions, Signs and Symptoms --- Phenomena and Processes --- Genetic Variation --- Oncology --- Medicine --- Health & Biological Sciences --- Cancer cells. --- Chromosome abnormalities. --- Chromosomal aberrations --- Chromosome anomalies --- Medicine. --- Cancer research. --- Human genetics. --- Oncology. --- Medicine & Public Health. --- Cancer Research. --- Human Genetics. --- Tumors --- Genetics --- Heredity, Human --- Human biology --- Physical anthropology --- Cancer research --- Clinical sciences --- Medical profession --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Chromosomes --- Karyotypes --- Mutation (Biology) --- Cells --- Pathology, Cellular --- Oncology .
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Human beings normally have a total of 46 chromosomes, with each chromosome present twice, apart from the X and Y chromosomes in males. Some three million people worldwide, however, have 47 chromosomes: they have a small supernumerary marker chromosome (sSMC) in addition to the 46 normal ones. This sSMC can originate from any one of the 24 human chromosomes and can have different shapes. Approximately one third of sSMC carriers show clinical symptoms, while the remaining two thirds manifest no phenotypic effects. This guide represents the first book ever published on this topic. It presents the latest research results on sSMC and current knowledge about the genotype-phenotype correlation. The focus is on genetic diagnostics as well as on prenatal and fertility-related genetic counseling. A unique feature is that research meets practice: numerous patient reports complement the clinical aspects and depict the experiences of families living with a family member with an sSMC.
Genetic disorders. --- Human cytogenetics. --- Medical genetics. --- Medical genetics --- Human cytogenetics --- Genetic disorders --- Study Characteristics --- Pathologic Processes --- Mutation --- Genetic Diseases, Inborn --- Congenital Abnormalities --- Congenital, Hereditary, and Neonatal Diseases and Abnormalities --- Genetic Variation --- Publication Characteristics --- Pathological Conditions, Signs and Symptoms --- Genetic Phenomena --- Diseases --- Phenomena and Processes --- Case Reports --- Chromosome Aberrations --- Chromosome Disorders --- Medicine --- Biology --- Health & Biological Sciences --- Pathology --- Genetics --- Congenital diseases --- Disorders, Genetic --- Disorders, Inherited --- Genetic diseases --- Hereditary diseases --- Inherited diseases --- Cytogenetics, Human --- Clinical genetics --- Heredity of disease --- Genetic aspects --- Medicine. --- Human genetics. --- Cytogenetics. --- Laboratory medicine. --- Reproductive medicine. --- Biomedicine. --- Human Genetics. --- Reproductive Medicine. --- Laboratory Medicine. --- Cytogenetics --- Human genetics --- Medical sciences
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Limiting genome replication to once per cell cycle is vital for maintaining genome stability. Although polyploidization is of physiologically importance for several specialized cell types, inappropriate polyploidization is believed to promote aneuploidy and transformation. A growing body of evidence indicates that the surveillance mechanisms that prevent polyploidization are frequently perturbed in cancers. Progress in the past several years has unraveled some of the underlying principles that maintain genome stability. This book brings together leaders of the field to overview subjects relating to polyploidization and cancer.
Cancer --Genetic aspects. --- Polyploidy. --- Cancer --- Polyploidy --- Chromosome Aberrations --- Biology --- Ploidies --- Gene Expression Regulation --- Genomic Instability --- Diseases --- Pathologic Processes --- Genetic Phenomena --- Biological Science Disciplines --- Mutation --- Genetic Processes --- Phenomena and Processes --- Natural Science Disciplines --- Genetic Variation --- Pathological Conditions, Signs and Symptoms --- Disciplines and Occupations --- Chromosomal Instability --- Neoplasms --- Gene Expression Regulation, Neoplastic --- Genetics --- Medicine --- Health & Biological Sciences --- Oncology --- Genetic aspects --- Genetic aspects. --- Cancer genetics --- Medicine. --- Biomedicine. --- Biomedicine general. --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Chromosome numbers --- Cancer genes --- Health Workforce --- Biomedicine, general.
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Genetics --- Chromosomes --- Chromosome Aberrations. --- Mutation. --- Génétique --- Chromosomes. --- Genetics. --- Chromosome theory --- Mutations --- Abnormalities, Autosome --- Abnormalities, Chromosomal --- Abnormalities, Chromosome --- Chromosomal Aberrations --- Chromosome Abnormalities --- Cytogenetic Abnormalities --- Autosome Abnormalities --- Cytogenetic Aberrations --- Aberration, Chromosomal --- Aberration, Chromosome --- Aberration, Cytogenetic --- Aberrations, Chromosomal --- Aberrations, Chromosome --- Aberrations, Cytogenetic --- Abnormalities, Cytogenetic --- Abnormality, Autosome --- Abnormality, Chromosomal --- Abnormality, Chromosome --- Abnormality, Cytogenetic --- Autosome Abnormality --- Chromosomal Aberration --- Chromosomal Abnormalities --- Chromosomal Abnormality --- Chromosome Aberration --- Chromosome Abnormality --- Cytogenetic Aberration --- Cytogenetic Abnormality --- abnormalities --- Biology --- Embryology --- Mendel's law --- Adaptation (Biology) --- Breeding --- Heredity --- Mutation (Biology) --- Variation (Biology) --- Cell nuclei --- Crossing over (Genetics) --- Cytotaxonomy --- Karyokinesis --- Linkage (Genetics) --- DNA Damage --- Polymorphism, Restriction Fragment Length --- Cytogenetics --- Genetics, Medical --- Cytogenetic Analysis
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Genetics --- Cell Transformation, Neoplastic --- Chromosome Aberrations --- Neoplasms --- Cancer --- Cancer genes --- Gènes du cancer --- genetics --- Genetic aspects --- Periodicals. --- Periodicals --- Aspect génétique --- Périodiques --- Cell Transformation, Neoplastic. --- Chromosome Aberrations. --- genetics. --- Genetic aspects. --- Abnormalities, Autosome --- Abnormalities, Chromosomal --- Abnormalities, Chromosome --- Chromosomal Aberrations --- Chromosome Abnormalities --- Cytogenetic Abnormalities --- Autosome Abnormalities --- Cytogenetic Aberrations --- Aberration, Chromosomal --- Aberration, Chromosome --- Aberration, Cytogenetic --- Aberrations, Chromosomal --- Aberrations, Chromosome --- Aberrations, Cytogenetic --- Abnormalities, Cytogenetic --- Abnormality, Autosome --- Abnormality, Chromosomal --- Abnormality, Chromosome --- Abnormality, Cytogenetic --- Autosome Abnormality --- Chromosomal Aberration --- Chromosomal Abnormalities --- Chromosomal Abnormality --- Chromosome Aberration --- Chromosome Abnormality --- Cytogenetic Aberration --- Cytogenetic Abnormality --- Chromosomes --- Cytogenetics --- Genetics, Medical --- Cytogenetic Analysis --- Neoplastic Cell Transformation --- Transformation, Neoplastic Cell --- Tumorigenic Transformation --- Neoplastic Transformation, Cell --- Cell Neoplastic Transformation --- Cell Neoplastic Transformations --- Cell Transformations, Neoplastic --- Neoplastic Cell Transformations --- Neoplastic Transformations, Cell --- Transformation, Cell Neoplastic --- Transformation, Tumorigenic --- Transformations, Cell Neoplastic --- Transformations, Neoplastic Cell --- Transformations, Tumorigenic --- Tumorigenic Transformations --- Cell Line, Transformed --- abnormalities --- Medical oncology --- Chemistry --- Health Sciences --- Life Sciences --- Biochemistry --- Clinical Medicine --- Oncology --- Genomics --- Cytogenetics. --- Medical oncology. --- periodicals --- periodicals. --- Aspect génétique --- Périodiques --- Cancer genetics --- Cancers --- Carcinoma --- Malignancy (Cancer) --- Malignant tumors --- Tumors --- Benign Neoplasms --- Malignancy --- Malignant Neoplasms --- Neoplasia --- Neoplasm --- Neoplasms, Benign --- Benign Neoplasm --- Malignancies --- Malignant Neoplasm --- Neoplasias --- Neoplasm, Benign --- Neoplasm, Malignant --- Neoplasms, Malignant --- Tumor --- Medical Oncology --- Chromosome abnormalities. --- Aberrations chromosomiques. --- Chromosomal aberrations --- Chromosome anomalies --- Karyotypes --- Mutation (Biology)
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Bioethics --- Chromosome Aberrations --- Genetic Diseases, Inborn --- Genetics, Medical --- Medische genetica. --- Health Sciences --- Genetics --- Medical genetics --- Human genetics --- Génétique médicale --- Génétique humaine --- Bioéthique --- Bioethics. --- Human genetics. --- Medical genetics. --- Chromosome Aberrations. --- Genetic Diseases, Inborn. --- Genetics, Medical. --- Biology --- Biomedical ethics --- Life sciences --- Life sciences ethics --- Science --- Clinical genetics --- Diseases --- Heredity of disease --- Medical sciences --- Pathology --- Genetic disorders --- Heredity, Human --- Human biology --- Physical anthropology --- Genetic Diseases --- Genetic Disorders --- Hereditary Disease --- Inborn Genetic Diseases --- Single-Gene Defects --- Hereditary Diseases --- Defect, Single-Gene --- Defects, Single-Gene --- Disease, Genetic --- Disease, Hereditary --- Disease, Inborn Genetic --- Diseases, Genetic --- Diseases, Hereditary --- Diseases, Inborn Genetic --- Disorder, Genetic --- Disorders, Genetic --- Genetic Disease --- Genetic Disease, Inborn --- Genetic Disorder --- Inborn Genetic Disease --- Single Gene Defects --- Single-Gene Defect --- Abnormalities, Autosome --- Abnormalities, Chromosomal --- Abnormalities, Chromosome --- Chromosomal Aberrations --- Chromosome Abnormalities --- Cytogenetic Abnormalities --- Autosome Abnormalities --- Cytogenetic Aberrations --- Aberration, Chromosomal --- Aberration, Chromosome --- Aberration, Cytogenetic --- Aberrations, Chromosomal --- Aberrations, Chromosome --- Aberrations, Cytogenetic --- Abnormalities, Cytogenetic --- Abnormality, Autosome --- Abnormality, Chromosomal --- Abnormality, Chromosome --- Abnormality, Cytogenetic --- Autosome Abnormality --- Chromosomal Aberration --- Chromosomal Abnormalities --- Chromosomal Abnormality --- Chromosome Aberration --- Chromosome Abnormality --- Cytogenetic Aberration --- Cytogenetic Abnormality --- Chromosomes --- Cytogenetics --- Cytogenetic Analysis --- Medical Genetics --- Anthropology, Physical --- Chromosome Disorders --- Sex Chromosome Disorders --- Molecular Medicine --- Biomedical Ethics --- Health Care Ethics --- Ethics, Biomedical --- Ethics, Health Care --- Ethics, Medical --- Ethicists --- Moral and ethical aspects --- Genetic aspects --- abnormalities --- genetica --- genetics --- geneeskunde --- medicine --- genetische stoornissen --- genetic disorders --- mens --- man --- humane ziekten --- human diseases --- Genetics (General) --- Medicine (General) --- Genetica (algemeen) --- Geneeskunde (algemeen) --- Chromosome abnormalities. --- Genetic disorders. --- Bioéthique. --- Aberrations chromosomiques. --- Maladies génétiques. --- Génétique médicale. --- Congenital diseases --- Disorders, Inherited --- Genetic diseases --- Hereditary diseases --- Inherited diseases --- Chromosomal aberrations --- Chromosome anomalies --- Karyotypes --- Mutation (Biology) --- Chromosome abnormalities
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Genetics --- Medical genetics --- Génétique médicale --- Periodicals. --- Périodiques --- Genetic Diseases, Inborn. --- Chromosome Aberrations. --- Genetics, Medical. --- Medical genetics. --- Human Genetics --- Medical Genetics --- Genetics, Human --- Anthropology, Physical --- Chromosome Disorders --- Sex Chromosome Disorders --- Genetic Diseases, Inborn --- Molecular Medicine --- Abnormalities, Autosome --- Abnormalities, Chromosomal --- Abnormalities, Chromosome --- Chromosomal Aberrations --- Chromosome Abnormalities --- Cytogenetic Abnormalities --- Autosome Abnormalities --- Cytogenetic Aberrations --- Aberration, Chromosomal --- Aberration, Chromosome --- Aberration, Cytogenetic --- Aberrations, Chromosomal --- Aberrations, Chromosome --- Aberrations, Cytogenetic --- Abnormalities, Cytogenetic --- Abnormality, Autosome --- Abnormality, Chromosomal --- Abnormality, Chromosome --- Abnormality, Cytogenetic --- Autosome Abnormality --- Chromosomal Aberration --- Chromosomal Abnormalities --- Chromosomal Abnormality --- Chromosome Aberration --- Chromosome Abnormality --- Cytogenetic Aberration --- Cytogenetic Abnormality --- Chromosomes --- Cytogenetics --- Genetics, Medical --- Cytogenetic Analysis --- Genetic Diseases --- Genetic Disorders --- Hereditary Disease --- Inborn Genetic Diseases --- Single-Gene Defects --- Hereditary Diseases --- Defect, Single-Gene --- Defects, Single-Gene --- Disease, Genetic --- Disease, Hereditary --- Disease, Inborn Genetic --- Diseases, Genetic --- Diseases, Hereditary --- Diseases, Inborn Genetic --- Disorder, Genetic --- Disorders, Genetic --- Genetic Disease --- Genetic Disease, Inborn --- Genetic Disorder --- Inborn Genetic Disease --- Single Gene Defects --- Single-Gene Defect --- abnormalities --- Periodicals --- Health Sciences --- Pathology --- Génétique médicale --- Périodiques --- EJBIOMO EJMEDEC ELSEVIER-E EPUB-ALPHA-E EPUB-PER-FT MDGENETI --- Clinical genetics --- Diseases --- Heredity of disease --- Genetic aspects --- Chromosome Aberrations --- Human genetics --- Medical sciences --- Genetic disorders --- Genetica
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"This book covers the core scientific principles necessary for an understanding of medical genetics and its clinical applications, while also considering the social implications of genetic disorders. This third edition has been fully updated to include the latest developments in the field, covering the most common genetic anomalies, their diagnosis and management, in clear, concise and revision-friendly sections to complement any health science course."--Publisher.
Genetic Diseases, Inborn. --- Chromosome Aberrations. --- Genetics, Medical. --- Medical genetics. --- Developmental biology. --- Génétique médicale --- Biologie du développement --- Medical genetics --- Developmental biology --- Genetic Diseases, Inborn --- Chromosome Aberrations --- Genetics, Medical --- Genetic Testing --- Genetic Screening --- Predictive Genetic Testing --- Predictive Testing, Genetic --- Testing, Genetic Predisposition --- Genetic Predisposition Testing --- Genetic Predictive Testing --- Genetic Screenings --- Genetic Testing, Predictive --- Predisposition Testing, Genetic --- Screening, Genetic --- Screenings, Genetic --- Testing, Genetic --- Testing, Genetic Predictive --- Testing, Predictive Genetic --- Genetic Predisposition to Disease --- Prenatal Diagnosis --- Preimplantation Diagnosis --- Cytogenetic Analysis --- Molecular Diagnostic Techniques --- Databases, Genetic --- Databases, Nucleic Acid --- Genetic Privacy --- Medical Genetics --- Anthropology, Physical --- Chromosome Disorders --- Sex Chromosome Disorders --- Molecular Medicine --- Abnormalities, Autosome --- Abnormalities, Chromosomal --- Abnormalities, Chromosome --- Chromosomal Aberrations --- Chromosome Abnormalities --- Cytogenetic Abnormalities --- Autosome Abnormalities --- Cytogenetic Aberrations --- Aberration, Chromosomal --- Aberration, Chromosome --- Aberration, Cytogenetic --- Aberrations, Chromosomal --- Aberrations, Chromosome --- Aberrations, Cytogenetic --- Abnormalities, Cytogenetic --- Abnormality, Autosome --- Abnormality, Chromosomal --- Abnormality, Chromosome --- Abnormality, Cytogenetic --- Autosome Abnormality --- Chromosomal Aberration --- Chromosomal Abnormalities --- Chromosomal Abnormality --- Chromosome Aberration --- Chromosome Abnormality --- Cytogenetic Aberration --- Cytogenetic Abnormality --- Chromosomes --- Cytogenetics --- Genetic Diseases --- Genetic Disorders --- Hereditary Disease --- Inborn Genetic Diseases --- Single-Gene Defects --- Hereditary Diseases --- Defect, Single-Gene --- Defects, Single-Gene --- Disease, Genetic --- Disease, Hereditary --- Disease, Inborn Genetic --- Diseases, Genetic --- Diseases, Hereditary --- Diseases, Inborn Genetic --- Disorder, Genetic --- Disorders, Genetic --- Genetic Disease --- Genetic Disease, Inborn --- Genetic Disorder --- Inborn Genetic Disease --- Single Gene Defects --- Single-Gene Defect --- Development (Biology) --- Biology --- Growth --- Ontogeny --- Clinical genetics --- Diseases --- Heredity of disease --- Human genetics --- Medical sciences --- Pathology --- Genetic disorders --- diagnosis --- abnormalities --- Genetic aspects --- medische genetica --- aangeboren afwijkingen --- Genetic disorders. --- Chromosome abnormalities. --- Genetic screening.
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Molecular biology --- Genetics --- Biology --- Cytogenetics --- Biologie --- Cytogénétique --- Biologie moléculaire --- Periodicals --- periodicals --- Périodiques --- Biology. --- Cytogenetics. --- Périodiques. --- Chemistry. --- Biochemistry, --- Physical Chemistry, --- Biotechnology, --- Immunology, --- Molecular biology, --- Cytogenetics, --- Biology, --- Engineering. --- Health Sciences. --- Life Sciences. --- Chemistry --- Engineering --- Health Sciences --- Life Sciences --- Biochemistry --- Physical Chemistry --- Biotechnology --- Immunology --- General and Others --- Molecular biology. --- Cytogenetic --- Molecular biochemistry --- Molecular biophysics --- Cytogenetic Analysis --- Chromosome Disorders --- Sex Chromosome Disorders --- Cytology --- Biophysics --- Biomolecules --- Systems biology --- Life sciences --- Biomass --- Life (Biology) --- Natural history --- moleculaire biologie --- cytogenetics. --- Biological Sciences. --- biology --- aerobiology --- agricultural sciences --- anatomy and morphology --- behavior --- biochemistry --- biogenesis --- biogeography --- bioinformatics --- biological properties and phenomena --- biomathematics --- botany --- cell biology --- cryobiology --- embryology --- endocrinology --- evolutionary biology --- genetics --- histology --- immunology --- ionomics --- life history --- microbiology --- molecular biology --- mycology --- natural history --- neontology --- nutrition --- organisms --- paleontology --- parasitology --- photobiology --- physiology --- psychology --- sociobiology --- structural biology --- synthetic biology --- taxonomy --- zoology --- biologists --- hematology --- laboratory techniques --- cell cycle --- chimerism --- chromosome aberrations --- chromosome morphology --- chromosome number --- chromosome transmission --- chromosomes --- crossing over --- crossover interference --- cytogenetic analysis --- heterokaryon --- homokaryon --- mixoploidy --- ploidy
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