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This Special Issue “Applications of Stable Isotopes and Tritium in Hydrology” addresses the current state-of-the-art applications of stable isotopes and tritium in studies of hydrological process and the whole water cycle. The six scientific papers belonging to this SI show a wide variety of isotope applications in various studies performed locally or regionally, but the conclusions obtained may be valid worldwide. Precipitation, groundwater, and surface waters belong to classical water bodies, while evapotranspiration, effects of farming, and drip water in karst caves seldom present applications of water isotopes.
Salmonella --- biofilm --- innate immunity --- extracellular polymeric substances --- S. Typhi --- S. Typhimurium --- S. diarizonae --- PagN --- adhesin --- invasin --- alleles --- allelic variants --- organoids --- enteroids --- host-pathogen interactions --- model systems --- infectious diseases --- organotypic culture system --- genomic island --- SPI-1 --- pathogenicity island --- comparative genomics --- type III secretion system --- host adaptation --- convergent evolution --- genome degradation --- genomic lesions --- Salmonella Typhi --- two-component system --- cpxR --- CsgD --- curli --- cellulose --- CpxR --- plasmid --- Salmonella enterica --- antimicrobial resistance --- long-read sequencing --- hybrid assembly --- iron homeostasis and regulation --- chicken --- pathogenicity --- iron transport --- n/a
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Pharmacogenomics is one of the emerging approaches to precision medicine, tailoring drug selection and dosing to the patient’s genetic features. In recent years, several pharmacogenetic guidelines have been published by international scientific consortia, but the uptake in clinical practice is still poor. Many coordinated international efforts are ongoing in order to overcome the existing barriers to pharmacogenomic implementation. On the other hand, existing validated pharmacogenomic markers can explain only a minor part of the observed clinical variability in the therapeutic outcome. New investigational approaches are warranted, including a study of the pharmacogenomic role of the immune system genetics and of previously neglected rare genetic variants, reported to account for a large part of inter-individual variability in drug metabolism. In this book, we have collected a series of articles covering many aspects of pharmacogenomics. These include clinical implementation of pharmacogenomics in clinical practice, development of tools or infrastructures to support this process, research of new pharmacogenomics markers to increase drug efficacy and safety, and the impact of rare genetic variants in pharmacogenomics.
CYP2C9 --- VKORC1 --- warfarin --- warfarin initiation phase of therapy --- INR --- pharmacogenetics study --- pharmacogenomics --- pharmacogenetics --- genotype --- phenotype --- alleles --- precision medicine --- pharmacotranscriptomics --- high-throughput analysis --- childhood acute lymphoblastic leukemia --- clopidogrel --- acenocoumarol --- CDSS --- implementation --- azathioprine --- inflammatory bowel disease --- glutathione-S transferase --- pharmacokinetics --- nucleoside analogs --- microRNAs --- gene expression --- drug resistance --- AML --- cisplatin --- nephrotoxicity --- kidney injury --- genetic polymorphisms --- pre-emptive --- panel --- breast cancer subtype --- miRNA --- pathway --- crosstalk network --- precision drugs --- ovarian cancer --- platinum resistance --- focal copy number alterations --- whole exome sequencing --- personalized medicine --- human genetics --- pharmacology
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This book focuses on conservation genetic (and genomic) papers that demonstrate applied outcomes that inform practical threatened species management. We cover a broad range of species and genetic approaches, but focus on how conservation genetic information is used to underpin management actions for species recovery. Through the exposition of a diversity of approaches, we aim to demonstrate to conservation managers and researchers how conservation genetics can inform on-ground species management.
small isolated population --- Mediterranean native trout --- morphological deformities --- Camphorosmoideae --- conservation genetics --- disjunct distribution --- population fragmentation --- population structure --- single nucleotide polymorphism (SNP) markers --- genetic diversity --- population viability analysis --- allele retention --- translocation --- conservation management --- threatened marsupial --- remnant --- conservation --- natural hybridisation --- Eucalyptus --- high throughput sequencing --- NGS --- South Australia --- golden bandicoot --- southern brown bandicoot --- quenda --- phylogenetic --- taxonomy --- evolutionarily significant unit --- ecosystem engineer --- genetic rescue --- genetic restoration --- supplementation --- disease --- inbreeding --- genetic swamping --- locally unique alleles --- population genetics --- marsupial --- adaptive potential --- Leadbeater’s possum --- Gymnobelideus leadbeateri --- ex situ conservation --- Psittacidae --- Ara macao --- Xcaret --- captive breeding --- climate drying --- cpDNA --- ecotype --- Evolutionarily Significant Units --- gene flow --- geographic expansion --- patchy abundance --- phylogeography --- n/a --- Leadbeater's possum
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Allohexaploid bread wheat and diploid barley are two of the most cultivated crops in the world. This book reports novel research and reviews concerning the use of modern technologies to understand the molecular bases for wheat and barley improvement. The contributions published in this book illustrate research advances in wheat and barley knowledge using modern molecular techniques. These molecular approaches cover genomic, transcriptomic, proteomic, and phenomic levels, together with new tools for gene identification and the development of novel molecular markers. Overall, the contributions for this book lead to a further understanding of regulatory systems in order to improve wheat and barley performance.
n/a --- biotechnology --- transgene --- Aegilops tauschii --- antioxidant enzymes --- aquaporin --- molecular marker --- Kompetitive Allele Specific PCR (KASP) --- transgenic wheat --- purple acid phosphatase phytase --- genome editing --- genes --- resistance --- genome assembly --- germination --- protein two-dimensional electrophoresis --- 1 --- disease resistance --- Thinopyrum --- plant --- oligo probe --- optical mapping --- genetic biofortification --- breeding --- population structure --- marker-assisted selection --- crops --- hybrid necrosis --- PAPhy --- Triticeae --- wheat --- Barley --- genome stability --- CRISPR --- powdery mildew --- RNA editing --- bread wheat --- allohexaploid --- nucleus --- chromatin --- introgression --- favorable alleles --- genetic engineering --- Tunisian landraces --- barely --- Pm40 --- Blumeria graminis f. sp. tritici --- Transcriptional dynamics --- Lr42 --- Triticum durum --- histochemical analysis --- molecular mapping --- ribosomal DNA --- 12-oxophytodienoate reductase --- small segment translocation --- HIGS --- Powdery mildew --- abiotic stress --- phytase --- RNA-seq --- Bulked segregant analysis-RNA-Seq (BSR-Seq) --- grain --- DArTseq technology --- center of diversity --- mature grain phytase activity (MGPA) --- cereals --- Grain development --- hybrid --- homoeolog --- 3D-FISH --- jasmonates --- Single nucleotide polymorphism (SNP) --- genetic diversity --- ND-FISH --- durum wheat --- protease --- transpiration --- TdPIP2 --- cereal cyst nematodes --- mass spectrometry --- 6R --- Landrace --- marker-trait associations --- BAC --- chromosome --- barley --- freezing tolerance --- KASP markers --- Triticum aestivum --- rye
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Alzheimer’s disease (AD) represents the most common form of dementia in the elderly population worldwide. AD is characterized by progressive neurodegeneration that leads to a gradual deterioration of memory and other cognitive functions. Given the global prevalence and impact of AD, there is a critical need to establish biomarkers that can be used to detect AD in individuals before the onset of clinical signs and provide mitigating therapeutics. The aim of this Special Issue is to discuss the current knowledge as well as future perspectives on the role of biomarkers in the screening, diagnosis, treatment and follow-up of AD.
flotillin --- Alzheimer’s disease --- biomarker --- exosomes --- beta-amyloid --- Tau --- aging --- biomarkers --- cytokines --- cognitive decline --- metabolomics --- neuroinflammation --- multivariate analysis --- physical performance --- person-tailored --- PET/CT --- (18F)FDG --- neuropsychological assessment --- APP mutations --- APOE alleles --- PSEN1 --- PSEN2 --- germline mutations --- late onset AD --- early onset AD --- familial AD --- genetics of AD --- mitochondrial spare respiratory capacity --- mitochondrial --- membrane potential --- glycolytic reserve --- semantic memory --- phonemic fluency --- episodic memory --- neuropsychology --- neuroimaging --- Alzheimer's disease --- mild cognitive impairment --- EEG --- TMS --- obesity --- diabetes --- inflammation --- Amyloid Beta --- mitochondrial dysfunction --- nutrition --- omega-3 fatty acids --- antioxidant --- carotenoids --- vitamin E --- cognition --- older adults --- ageing --- subjective cognitive decline --- clock genes --- Clock --- ApoE --- cardiovascular risk factors --- Alzheimer disease --- semantic priming --- amyloid beta --- cerebrospinal fluid --- amyloid beta peptide --- total tau --- phosphorylated tau --- diagnosis --- drug development --- clinical trials --- diagnostic research --- virus --- bacteria --- dementia --- blood --- behavioral and psychological symptoms of dementia (BPSD) --- Alzheimer’s disease (AD) --- neuropsychiatry inventory scale (NPI) --- endophenotypes --- CART analysis --- MTHFR --- APOE --- COMT --- genetic variants --- early diagnosis --- biofluids --- amyloid cascade hypothesis --- glucose metabolism --- adipose tissue dysfunction --- energetic metabolism --- lysosomes dysfunction --- Type-3-Diabetes --- neurodegeneration --- amyloid --- tau --- soluble TREM2 --- NfL --- Multiplex --- SiMoA --- diagnostics --- messenger RNA --- microRNA --- neurotropic microbes --- precision medicine --- prognostics --- synaptic biomarkers --- neurofilament light chain --- n/a --- Alzheimer's disease (AD)
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