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The concept of regenerating tissues, with properties and functions that mimic natural tissues, has attracted significant attention in recent years. It provides potential solutions for treating many diseases and other healthcare issues. To fully realize the potential of the approach, it is crucial to have a rational biomaterial design to create novel scaffolds, and other materials systems suitable for tissue engineering, repair and regeneration. Research advances on the topic include the design of new biomaterials and their composites, the scaffold fabrication via subtractive and additive manufacturing approaches, the development of implantable scaffolds for disease monitoring, diagnostics, and treatment, as well as the understanding of cells–biomaterial scaffolds interaction. This Special Issue, “Novel Biomaterials for Tissue Engineering”, covers a selection of timely research activities in the field of biomaterials for tissue engineering and regeneration purposes. Promising findings on different approaches to design and develop new biomaterials, biomaterial systems and methods for tissue engineering, are presented and discussed. Recent advances in biofabrication techniques for tissue engineering are additionally demonstrated. The issue comprises a series of state-of-the-art experimental works, up-to-date review articles and commentaries.

tissue regeneration --- biomaterial structuring --- tissue engineering --- implantable scaffolds --- scaffolds --- biomaterials --- bioprinting --- cell-biomaterial interaction

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Handbook of Tissue Engineering Scaffolds: Volume Two provides a comprehensive and authoritative review on recent advancements in the application and use of composite scaffolds in tissue engineering. Chapters focus on specific tissue/organ (mostly on the structure and anatomy), the materials used for treatment, natural composite scaffolds, synthetic composite scaffolds, fabrication techniques, innovative materials and approaches for scaffolds preparation, host response to the scaffolds, challenges and future perspectives, and more. Bringing all the information together in one major reference, the authors systematically review and summarize recent research findings, thus providing an in-depth understanding of scaffold use in different body systems.

Human biochemistry --- Manufacturing technologies --- Tissue scaffolds. --- Tissue engineering. --- Biomedical materials.

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This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact

Cutaneous wound healing --- Skin Regeneration --- Skin substitutes --- engineered scaffolds

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Sequential and reciprocal interactions between oral epithelial and cranial neural crest-derived mesenchymal cells give rise to the teeth and periodontium. Teeth are vital organs containing a rich number of blood vessels and nerve fibers within the dental pulp and periodontium. Teeth are composed by unique and specific collagenous (dentin, fibrillar cementum) and non-collagenous (enamel) highly mineralized extracellular matrices. Alveolar bone is another collagenous hard tissue that supports tooth stability and function through its close interaction with the periodontal ligament. Dental hard tissues are often damaged after infection or traumatic injuries that lead to the partial or complete destruction of the functional dental and supportive tissues. Well-established protocols are routinely used in dental clinics for the restoration or replacement of the damaged tooth and alveolar bone areas. Recent progress in the fields of cell biology, tissue engineering, and nanotechnology offers promising opportunities to repair damaged or missing dental tissues. Indeed, pulp and periodontal tissue regeneration is progressing rapidly with the application of stem cells, biodegradable scaffolds, and growth factors. Furthermore, methods that enable partial dental hard tissue repair and regeneration are being evaluated with variable degrees of success. However, these cell-based therapies are still incipient and many issues need to be addressed before any clinical application. The understanding of tooth and periodontal tissues formation would be beneficial for improving regenerative attempts in dental clinics. In the present e-book we have covered the various aspects dealing with dental and periodontal tissues physiology and regeneration in 6 chapters: 1. General principles on the use of stem cells for regenerating craniofacial and dental tissues 2. The roles of nerves, vessels and stem cell niches in tissue regeneration 3. Dental pulp regeneration and mechanisms of various odontoblast functions 4. Dental root and periodontal physiology, pathology and regeneration 5. Physiology and regeneration of the bone using various scaffolds and stem cell populations 6. Physiology, pathology and regeneration of enamel using dental epithelial stem cells

Stem Cells --- vasculature --- Regenerative dentistry --- scaffolds --- Periodontium --- enamel --- Tooth --- innervation --- Dental Pulp --- Tissue Engineering

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This book outlines the latest research on the design and fabrication of the biomaterials used in mimicked scaffolds for tissue engineering for maxillofacial and orthopedic applications. The book is written based on integration and optimized concepts of 3 main parts 1) principle of tissue engineering; 2) mimicking of structure and function of scaffolds which is similar to extracellular matrix (ECM); and 3) mimicked scaffolds for tissue engineering in maxillofacial and orthopedic surgery. The content of this book which is interdisciplinary in nature caters to medical product designers, materials scientists and engineers, biologists, and surgeons who have interest in the field of bone tissue engineering.

Chemistry --- General biophysics --- Pharmacology. Therapy --- Human medicine --- biologische materialen --- chemie --- geneeskunde --- histologie --- Articular cartilage. --- Maxilla --- Tissue scaffolds. --- Surgery.