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The book presents state-of-the-art developments in multiscale modeling and latest experimental data on multiscale mechanobiology of bone remodeling and adaptation including fracture healing applications. The multiscale models include musculoskeletal models describing bone-muscle interactions during daily activities such as walking or running, micromechanical models for estimation of bone mechanical properties, bone remodeling and adaptation models, cellular models describing the complex bone-cell interactions taking into account biochemical and biomechanical regulatory factors. Also subcellular processes are covered including arrangement of actin filaments due to mechanical loading and change of receptor configurations.

Bone remodeling. --- Bones --- Mechanical properties. --- Bone biomechanics --- Bone mechanics --- Mechanical properties of bones --- Remodeling, Bone --- Engineering. --- Orthopedics. --- Continuum mechanics. --- Biomaterials. --- Continuum Mechanics and Mechanics of Materials. --- Tissue remodeling --- Metabolism --- Mechanics. --- Mechanics, Applied. --- Solid Mechanics. --- Orthopaedics --- Orthopedia --- Surgery --- Biocompatible materials --- Biomaterials --- Medical materials --- Medicine --- Biomedical engineering --- Materials --- Biocompatibility --- Prosthesis --- Applied mechanics --- Engineering, Mechanical --- Engineering mathematics --- Classical mechanics --- Newtonian mechanics --- Physics --- Dynamics --- Quantum theory --- Bioartificial materials --- Hemocompatible materials --- Biomaterials (Biomedical materials)