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This unique and practical resource provides the most complete and concise summary of underlying principles and approaches to studying nucleic acid structure, including discussion of x-ray crystallography, NMR, molecular modelling, and databases. Its focus is on a survey of structures especially important for biomedical research and pharmacological applications. To aid novices, the book includes an introduction to technical lingo used to describe nucleic acid structure and conformations (roll, slide, twist, buckle, etc.). This completely updated edition features expanded coverage of the latest

Nucleic acids. --- Biomolecules. --- Biological molecules --- Molecules --- Molecular biology --- Polynucleotides --- Biomolecules

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MicroRNAs (miRNAs) are RNA molecules, conserved by evolution, that regulate gene expressions and their discovery has revolutionised both basic biomedical research and drug discovery. Expression levels of MiRNAs have been found to vary between tissues and with developmental stages and hence evaluation of the global expression of miRNAs potentially provides opportunities to identify regulatory points for many different biological processes. This wide-ranging 2007 reference work, written by leading experts from both academia and industry, will be an invaluable resource for all those wishing to use miRNA techniques in their own research, from graduate students, post-docs and researchers in academia to those working in R&D in biotechnology and pharmaceutical companies who need to understand this emerging technology. From the discovery of miRNAs and their functions to their detection and role in disease biology, this volume uniquely integrates the basic science with industry application towards drug validation, diagnostic and therapeutic development.

RNA. --- Nucleic acids. --- Polynucleotides --- Biomolecules --- Ribonucleic acid --- Ribose nucleic acid --- Nucleic acids --- Ribose

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This Special Issue comprises 15 papers broadly outlining current trends in nucleic acid biophysics. It contains original research papers and reviews on structure, stability, and interactions of canonical and non-canonical nucleic acids. The authors describe the use of established, time-honored experimental and computational techniques as well as their more recently developed counterparts. Molecular insights that can be gained from the papers collected in this issue range from the fundamental to the applied with emphasis on biological functions and biomedical prospects of nucleic acids. The collection is not meant to be exhaustive, but to highlight recent advances from select laboratories worldwide. Nevertheless, it represents a useful guide for scientists who wish to familiarize themselves with biophysical topics in nucleic acid research. This Special Issue will be useful both for researchers who study fundamental aspects of nucleic acid structure, stability, and dynamics, as well as for those that are mainly interested in practical biological and biomedical applications of nucleic acids.

Biophysics. --- Nucleic acids. --- Polynucleotides --- Biomolecules --- Biological physics --- Biology --- Medical sciences --- Physics

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Crystallography is the major method of determining structures of biological macromolecules yet crystallization techniques are still regarded as difficult to perform. In Practical Approach books the protocols have been written by experienced researchers and are tried and tested methods. The underlying theory is brought together with the laboratory protocols to provide researchers with the conceptual and methodological tools necessary to exploit these powerful techniques. Crystallization of Nucleic Acids and Proteins: A Practical Approach, Second edition, will be a useful manual of practical crystallization methods to researchers in molecular biology, crystallography, protein engineering, and biological chemistry.

Crystallization. --- Nucleic acids. --- Proteins. --- Proteids --- Biomolecules --- Polypeptides --- Proteomics --- Polynucleotides --- Chemistry --- Chemistry, Physical and theoretical --- Separation (Technology) --- Proteins --- Nucleic acids --- Analysis.

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Chemistry, Organic. --- Organic Chemistry. --- Organic chemistry --- Chemistry --- Chemistry of natural organic substances --- Molecular biology --- Organic chemistry. --- Nucleic acids. --- Nucleic acids --- Structure. --- Polynucleotides --- Biomolecules