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Palladacycles: Catalysis and Beyond provides an overview of recent research in palladacycles in catalysis for cross-coupling and similar reactions. In the quest for developing highly efficient and robust palladium-based catalysts for C-C bond formation via cross-coupling reactions, palladacycles have played a significant role. In recent years, they have found a wide variety of applications, ranging from catalysts for cross-coupling and related reactions, to their more recent application as anticancer agents. This book explores early examples of the use of palladacyclic complexes in catalysis employing azobenzene and hydrazobenzene as coordinating ligands. Its applications in processes such as selective reduction of alkenes, alkynes, or nitroalkanes are also covered. Palladacycles: Catalysis and Beyond reveals the tremendous advances that have taken place in the potential applications of palladacycles as versatile catalysts in academia and industry. It is a valuable resource for synthetic chemists, organometallic chemists, and chemical biologists.--
Catalysis. --- Polycyclic compounds. --- Catalysis --- Polycyclic Compounds
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This book describes the design, synthesis, performance and practical application of energetic materials. The book consists of thirteen chapters demonstrating the design routes of nitrogen-rich polycyclic-based energetic materials that are bicyclic, tricyclic and tetracyclic-based. It presents the synthesis of the energetic backbone, the construction of linkage and the introduction of energetic units, which could have a positive impact on the chemistry of not only on high-energy-density materials but also in other fields. The book also provides detailed analysis of the experimental methods discussed. Work in this area will benefit from the combine expertise from organic, inorganic and physical chemistry as well as other connected disciplines. As such this book has wide appeal and will help in increasing fundamental knowledge of nitrogen-rich heterocycles to eventually allow for this knowledge to be transferred into industrial applications.
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Polycyclic aromatic compounds --- Chemistry --- Physics --- General and Others --- Synthesis --- Thermodynamics and Heat Transfer --- PACs (Chemicals) --- Polynuclear aromatic compounds --- Aromatic compounds --- Polycyclic compounds --- Chemical technology
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Palladium in Heterocyclic Chemistry
Descriptive organic chemistry --- Heterocyclic Compounds. --- 661.898 --- 546.98 --- 547.057 --- Organopalladium compounds --- Palladium catalysts --- Heterocyclic compounds --- -#WSCH:LOSH --- Cycloids, Mixed (Chemistry) --- Heteroatomic compounds --- Heterocycles --- Mixed cycloids (Chemistry) --- Organic cyclic compounds --- Catalysts --- Palladium organic compounds --- Organotransition metal compounds --- Palladium compounds --- Compounds, Heterocyclic --- Palladium --- Organic chemistry--?.057 --- Synthesis --- Polycyclic Compounds --- 547.057 Organic chemistry--?.057 --- 546.98 Palladium --- 661.898 Palladium compounds --- Heterocyclic Compounds --- #WSCH:LOSH --- Organopalladium compounds. --- Palladium catalysts. --- Synthesis.
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see table of contents.
Chemistry. --- Organic Chemistry. --- Medicinal Chemistry. --- Biochemistry, general. --- Chemistry, Organic. --- Biochemistry. --- Chimie --- Chimie organique --- Biochimie --- Chemistry --- Biochemistry --- Physical Sciences & Mathematics --- Anthracyclines. --- Antibiotics. --- Organic chemistry. --- Medicinal chemistry. --- Anti-infective agents --- Microbial metabolites --- Allelopathic agents --- Antibiosis --- Pharmaceutical microbiology --- Phytoncides --- Aminoglycosides --- Antineoplastic antibiotics --- Polycyclic compounds --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Medical sciences --- Organic chemistry --- Composition --- Chemistry, Medical and pharmaceutical --- Chemistry, Pharmaceutical --- Drug chemistry --- Drugs --- Medical chemistry --- Medicinal chemistry --- Pharmacochemistry
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table of contents.
Chemistry. --- Organic Chemistry. --- Medicinal Chemistry. --- Biochemistry, general. --- Chemistry, Organic. --- Biochemistry. --- Chimie --- Chimie organique --- Biochimie --- Anthracyclines --- Biochemistry --- Oncology --- Chemistry --- Medicine --- Physical Sciences & Mathematics --- Health & Biological Sciences --- Anthracyclines. --- Pharmaceutical chemistry. --- Chemistry, Medical and pharmaceutical --- Chemistry, Pharmaceutical --- Drug chemistry --- Drugs --- Medical chemistry --- Medicinal chemistry --- Pharmacochemistry --- Organic chemistry. --- Medicinal chemistry. --- Aminoglycosides --- Antineoplastic antibiotics --- Polycyclic compounds --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Medical sciences --- Organic chemistry --- Composition
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Knowledge of cholesterol and its interaction with protein molecules is of fundamental importance in both animal and human biology. This book contains 22 chapters, dealing in depth with structural and functional aspects of the currently known and extremely diverse unrelated families of cholesterol-binding and cholesterol transport proteins. By drawing together this range of topics the Editor has attempted to correlate this broad field of study for the first time. Technical aspects are given considerable emphasis, particularly in relation cholesterol reporter molecules and to the isolation and study of membrane cholesterol- and sphingomyelin-rich "raft" domains. Cell biological, biochemical and clinical topics are included in this book, which serve to emphasize the acknowledged and important benefits to be gained from the study of cholesterol and cholesterol-binding proteins within the biomedical sciences and the involvement of cholesterol in several clinical disorders. It is hoped that by presenting this topic in this integrated manner that an appreciation of the fact that there is much more that needs to be taken into account, studied and understood than the widely discussed "bad and good cholesterol" associated, respectively, with the low- and high-density lipoproteins, LDL and HDL.
Carrier proteins. --- Cholesterol -- Metabolism. --- Cholesterol --- Carrier proteins --- Sterols --- Proteins --- Cholestenes --- Carrier Proteins --- Membrane Lipids --- Amino Acids, Peptides, and Proteins --- Cholestanes --- Lipids --- Steroids --- Chemicals and Drugs --- Polycyclic Compounds --- Human Anatomy & Physiology --- Chemistry --- Biology --- Biology - General --- Animal Biochemistry --- Cytology --- Biochemistry --- Health & Biological Sciences --- Physical Sciences & Mathematics --- Metabolism --- Cholesterol. --- Metabolism. --- Binding proteins --- Transport proteins --- Cholesterin --- Life sciences. --- Biochemistry. --- Proteins. --- Lipids. --- Apoptosis. --- Life Sciences. --- Biochemistry, general. --- Lipidology. --- Protein Science. --- Animal Biochemistry. --- Biological transport --- Protein binding --- Isopentenoids --- Low-cholesterol diet
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Mifepristone --- Abortifacients --- Progesterone --- Reproductive Control Agents --- Estrenes --- Pregnenediones --- Corpus Luteum Hormones --- Progesterone Congeners --- Therapeutic Uses --- Estranes --- Gonadal Hormones --- Pregnenes --- Gonadal Steroid Hormones --- Physiological Effects of Drugs --- Steroids --- Pharmacologic Actions --- Hormones --- Pregnanes --- Polycyclic Compounds --- Chemical Actions and Uses --- Hormones, Hormone Substitutes, and Hormone Antagonists --- Chemicals and Drugs --- Abortifacient Agents --- Medicine --- Health & Biological Sciences --- Gynecology & Obstetrics --- Research --- Antagonists --- Research. --- Corpus luteum hormone --- Luteal hormone --- Mifeprex (Trademark) --- RU-486 (Drug) --- RU486 (Drug) --- Progestational hormones --- Abortion --- Obstetrical pharmacology --- Emmenagogues --- Oral contraceptives --- Contraceptives, Postconception --- Postconception contraceptives --- Drugs
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A copper-catalyzed direct synthesis of 2-(aminomethyl)indoles by catalytic domino reaction including multi-component coupling was developed, and is the first example of a three-component indole formation without producing salts as a byproduct. Based on this reaction, a copper-catalyzed synthesis of 3-(aminomethyl)isoquinoline was accomplished which represents an unprecedented isoquinoline synthesis through a four-component coupling reaction. Following these results, extensive application studies using one-pot palladium-, acid-, or base-promoted cyclization revealed that indole- or isoquinoline-fused polycyclic compounds can be readily synthesized through multi-component reactions. As the concept of Green Chemistry becomes ever more important, these findings may provide efficient and atom-economical approaches to the diversity-oriented synthesis of bioactive compounds containing a complex structure. This could lead to development of promising drug leads with structural complexity. The work of this thesis will go on to inspire the synthetic research of many readers.
Organocopper compounds -- Handbooks, manuals, etc. --- Polycyclic compounds --- Organonitrogen compounds --- Chemistry --- Physical Sciences & Mathematics --- Biochemistry --- Organic Chemistry --- Synthesis --- Organic compounds --- Synthesis. --- Chemistry, Organic --- Chemistry, Synthetic organic --- Organic synthesis (Chemistry) --- Synthetic organic chemistry --- Chemistry. --- Organic chemistry. --- Medicinal chemistry. --- Organic Chemistry. --- Medicinal Chemistry. --- Chemistry, Organic. --- Biochemistry. --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Medical sciences --- Organic chemistry --- Composition --- Chemistry, Medical and pharmaceutical --- Chemistry, Pharmaceutical --- Drug chemistry --- Drugs --- Medical chemistry --- Medicinal chemistry --- Pharmacochemistry
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UV exposuie represents the most important risk factor for the development of nonmelanoma skin cancer. Additionally, assessment of sun exposure parameters has consistently shown an association between the development of malignant melanoma and short term, intense UV exposure, particularly burning in childhood. As a consequence, protection of the skin from UV exposure is an integral part of skin cancer prevention programs. However, more chronic, less intense UV exposure has not been found to be a risk factor for melanoma and in fact has been found in some studies to be protective. Moreover, 90% of all requisite vitamin D is formed within the skin through the action of the sun—a serious problem—for a connection between vitamin D deficiency and various types of cancer (e. g. , colon, prostate and breast cancers) has been demonstrated in a large number of studies. Hence, the - sociation between vitamin D deficiency and various internal malignancies has now opened a debate among dermatologists and other clinicians how to balance between positive and negative effects of solar and artificial UV exposure. The goal of this volume is to provide a comprehensive, highly readable overview of our present knowledge of positive and negative effects of UV exposure, with a focus on vitamin D and skin cancer.
Biomedicine. --- Cancer Research. --- Medicine. --- Oncology. --- Médecine --- Cancérologie --- Skin Neoplasms. --- Sunlight. --- Skin --- Sunshine --- Vitamin D --- Secosteroids --- Weather --- Light --- Neoplasms by Site --- Skin Diseases --- Neoplasms --- Radiation, Nonionizing --- Skin and Connective Tissue Diseases --- Atmosphere --- Meteorological Concepts --- Steroids --- Environment --- Polycyclic Compounds --- Diseases --- Ecological and Environmental Phenomena --- Radiation --- Electromagnetic Phenomena --- Biological Phenomena --- Chemicals and Drugs --- Physical Phenomena --- Phenomena and Processes --- Environment and Public Health --- Health Care --- Skin Neoplasms --- Sunlight --- Medicine --- Health & Biological Sciences --- Oncology --- Cancer --- Therapeutic use --- Sunshine. --- Cancer. --- Therapeutic use. --- Cancer research. --- Cancer research --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Calcium regulating hormones --- Steroid hormones --- Vitamins, Fat-soluble --- Meteorology --- Tumors
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