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Palladacycles : catalysis and beyond
Authors: ---
ISBN: 9780128165164 0128165162 9780128155059 0128155051 Year: 2019 Publisher: Amsterdam, Netherlands ; Kidlington, Oxford, England ; Cambridge, Massachusetts : Elsevier,

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Abstract

Palladacycles: Catalysis and Beyond provides an overview of recent research in palladacycles in catalysis for cross-coupling and similar reactions. In the quest for developing highly efficient and robust palladium-based catalysts for C-C bond formation via cross-coupling reactions, palladacycles have played a significant role. In recent years, they have found a wide variety of applications, ranging from catalysts for cross-coupling and related reactions, to their more recent application as anticancer agents. This book explores early examples of the use of palladacyclic complexes in catalysis employing azobenzene and hydrazobenzene as coordinating ligands. Its applications in processes such as selective reduction of alkenes, alkynes, or nitroalkanes are also covered. Palladacycles: Catalysis and Beyond reveals the tremendous advances that have taken place in the potential applications of palladacycles as versatile catalysts in academia and industry. It is a valuable resource for synthetic chemists, organometallic chemists, and chemical biologists.--


Book
Nitrogen-Rich Polycyclic-Based Energetic Materials
Authors: --- ---
ISBN: 9819745691 Year: 2024 Publisher: Singapore : Springer,

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Abstract

This book describes the design, synthesis, performance and practical application of energetic materials. The book consists of thirteen chapters demonstrating the design routes of nitrogen-rich polycyclic-based energetic materials that are bicyclic, tricyclic and tetracyclic-based. It presents the synthesis of the energetic backbone, the construction of linkage and the introduction of energetic units, which could have a positive impact on the chemistry of not only on high-energy-density materials but also in other fields. The book also provides detailed analysis of the experimental methods discussed. Work in this area will benefit from the combine expertise from organic, inorganic and physical chemistry as well as other connected disciplines. As such this book has wide appeal and will help in increasing fundamental knowledge of nitrogen-rich heterocycles to eventually allow for this knowledge to be transferred into industrial applications.


Periodical
Polycyclic aromatic compounds
ISSN: 15635333 10406638 Publisher: [Place of publication unknown]

Palladium in heterocyclic chemistry : a guide for the synthetic chemist
Authors: ---
ISBN: 0080437044 0080437052 9786612344985 1282344986 0080513484 9780080437057 9780080513485 9780080886749 0080886744 9780080437040 9781282344983 6612344989 Year: 2000 Publisher: Amsterdam, [Netherlands] : Pergamon,


Book
Anthracycline chemistry and biology II : mode of action, clinical aspects and new drugs
Author:
ISBN: 9783540758136 3540758127 9783540758129 3540758135 Year: 2008 Publisher: Berlin, Germany : Springer,


Book
Anthracycline chemistry and biology i : biological occurrence and biosynthesis, synthesis and chemistry
Author:
ISSN: 03401022 ISBN: 9783540758150 3540758143 9783540758143 3540758151 Year: 2008 Volume: 282 Publisher: Berlin, Germany : Springer,


Book
Cholesterol binding and cholesterol transport proteins : structure and function in health and disease
Author:
ISBN: 9048186218 9786612924750 9048186226 1282924753 Year: 2010 Publisher: Dordrecht ; New York : Springer,

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Knowledge of cholesterol and its interaction with protein molecules is of fundamental importance in both animal and human biology. This book contains 22 chapters, dealing in depth with structural and functional aspects of the currently known and extremely diverse unrelated families of cholesterol-binding and cholesterol transport proteins. By drawing together this range of topics the Editor has attempted to correlate this broad field of study for the first time. Technical aspects are given considerable emphasis, particularly in relation cholesterol reporter molecules and to the isolation and study of membrane cholesterol- and sphingomyelin-rich "raft" domains. Cell biological, biochemical and clinical topics are included in this book, which serve to emphasize the acknowledged and important benefits to be gained from the study of cholesterol and cholesterol-binding proteins within the biomedical sciences and the involvement of cholesterol in several clinical disorders. It is hoped that by presenting this topic in this integrated manner that an appreciation of the fact that there is much more that needs to be taken into account, studied and understood than the widely discussed "bad and good cholesterol" associated, respectively, with the low- and high-density lipoproteins, LDL and HDL.

Clinical applications of mifepristone (RU 486) and other antiprogestins : assessing the science and recommending a research agenda
Authors: --- ---
ISBN: 0309049490 9786610196029 1280196025 0309598354 0585024782 9780585024783 9781280196027 6610196028 9780309598354 9780309049498 Year: 1993 Publisher: Washington, D.C. : National Academy Press,


Book
Copper-catalyzed multi-component reactions : synthesis of nitrogen-containing polycyclic compounds
Author:
ISBN: 3642154727 9786613081834 3642154735 1283081830 Year: 2011 Publisher: Dordrecht : Springer,

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A copper-catalyzed direct synthesis of 2-(aminomethyl)indoles by catalytic domino reaction including multi-component coupling was developed, and is the first example of a three-component indole formation without producing salts as a byproduct. Based on this reaction, a copper-catalyzed synthesis of 3-(aminomethyl)isoquinoline was accomplished which represents an unprecedented isoquinoline synthesis through a four-component coupling reaction. Following these results, extensive application studies using one-pot palladium-, acid-, or base-promoted cyclization revealed that indole- or isoquinoline-fused polycyclic compounds can be readily synthesized through multi-component reactions. As the concept of Green Chemistry becomes ever more important, these findings may provide efficient and atom-economical approaches to the diversity-oriented synthesis of bioactive compounds containing a complex structure. This could lead to development of promising drug leads with structural complexity. The work of this thesis will go on to inspire the synthetic research of many readers.


Book
Sunlight, vitamin D and skin cancer
Author:
ISBN: 9780387775746 0387775730 9780387775739 1441926577 9786611960087 128196008X 0387775749 Year: 2008 Publisher: New York, N.Y. : Austin, Tex. : Springer Science+Business Media ; Landes Bioscience,

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Abstract

UV exposuie represents the most important risk factor for the development of nonmelanoma skin cancer. Additionally, assessment of sun exposure parameters has consistently shown an association between the development of malignant melanoma and short term, intense UV exposure, particularly burning in childhood. As a consequence, protection of the skin from UV exposure is an integral part of skin cancer prevention programs. However, more chronic, less intense UV exposure has not been found to be a risk factor for melanoma and in fact has been found in some studies to be protective. Moreover, 90% of all requisite vitamin D is formed within the skin through the action of the sun—a serious problem—for a connection between vitamin D deficiency and various types of cancer (e. g. , colon, prostate and breast cancers) has been demonstrated in a large number of studies. Hence, the - sociation between vitamin D deficiency and various internal malignancies has now opened a debate among dermatologists and other clinicians how to balance between positive and negative effects of solar and artificial UV exposure. The goal of this volume is to provide a comprehensive, highly readable overview of our present knowledge of positive and negative effects of UV exposure, with a focus on vitamin D and skin cancer.

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