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"Journal of Angiogenesis Research is an open access journal that publishes original research and timely reviews on recent advances in the understanding of the processes responsible for neovascularisation and pathological angiogenesis."

Neovascularization, Physiologic --- Neovascularization, Pathologic --- Neovascularization --- Néovascularisation --- Periodicals. --- Périodiques --- Neovascularization, Physiologic. --- Neovascularization, Pathologic. --- Neovascularization. --- Angiogenesis --- Angiogenesis, Pathological --- Neovascularization, Pathological --- Pathologic Angiogenesis --- Pathologic Neovascularization --- Angiogenesis, Pathologic --- Pathological Angiogenesis --- Pathological Neovascularization --- Angiogenesis, Physiological --- Neovascularization, Physiological --- Physiologic Angiogenesis --- Physiologic Neovascularization --- Angiogenesis, Physiologic --- Physiological Angiogenesis --- Physiological Neovascularization --- Blood-vessels --- Vascular Remodeling --- Collateral Circulation --- Growth --- Physiology

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Ischemia. --- Arteriosclerosis. --- Efferent pathways. --- Motor nervous system --- Motor pathways --- Motor tracts --- Arterial sclerosis --- Arteries --- Hardening of the arteries --- Sclerosis, Arterial --- Ischaemia --- Hardening --- Sclerosis --- Central nervous system --- Arterial occlusions --- Blood circulation disorders --- Ischemia --- Arteriosclerosis --- Efferent Pathwayx --- Neovascularization, Physiologic --- therapy --- Ischemia - therapy --- Arteriosclerosis - therapy

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Angiogenesis is the growth of new blood vessels and is a key process which occurs during pathological disease progression. Excessive and damaging angiogenesis occurs in diseases such as cancer, diabetic retinopathies, age-related macular degeneration and atherosclerosis. In other diseases such as stroke and myocardial infarction, insufficient or improper angiogenesis results in tissue loss and ultimately higher morbidity and mortality. In this book we will begin by providing the reader with an overview of the process of angiogenesis including normal embryological development of blood vessels. The following chapters will each focus on a key angiogenic disease incorporating current scientific knowledge concerning the causes of activation of the “angiogenic switch”, pathological consequences, current treatment options and future perspectives. Where appropriate, results from pre-clinical trials, novel imaging modalities and nanotechnological approaches will be incorporated into these sections. Finally, since it is now believed that the process of angiogenesis operated via different signalling mechanisms in different vascular beds, we will discuss our current understanding of this phenomenon. The target audience for this book would include researchers in all the basic sciences; post-graduate students at Universities and Institutes; pharmaceutical industries; clinicians working in vascular biology or tissue imaging; pathologists; neurologists; tumour biologists; ophthalmologists and cardiologists.

Cardiovascular system -- Diseases -- Treatment. --- Neovascularization. --- Cardiovascular Physiological Processes --- Cardiovascular Diseases --- Diseases --- Cardiovascular Physiological Phenomena --- Neovascularization, Physiologic --- Vascular Diseases --- Circulatory and Respiratory Physiological Phenomena --- Phenomena and Processes --- Medicine --- Health & Biological Sciences --- Oncology --- Blood-vessels --- Treatment. --- Angiology --- Vascular system --- Vasculature --- Angiogenesis --- Medicine. --- Cancer research. --- Human genetics. --- Molecular biology. --- Neurosciences. --- Oncology. --- Biomedicine. --- Cancer Research. --- Molecular Medicine. --- Human Genetics. --- Cardiovascular system --- Growth --- Oncology  . --- Genetics --- Heredity, Human --- Human biology --- Physical anthropology --- Neural sciences --- Neurological sciences --- Neuroscience --- Medical sciences --- Nervous system --- Clinical sciences --- Medical profession --- Life sciences --- Pathology --- Physicians --- Tumors --- Health Workforce --- Molecular biochemistry --- Molecular biophysics --- Biochemistry --- Biophysics --- Biomolecules --- Systems biology --- Cancer research

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In 1971, J. Folkman published in the "New England Journal of Medicine" a hypothesis that tumor growth is angiogenesis-dependent. Folkman introduced the concept that tumors probably secrete diffusible molecules that could stimulate the growth of new blood vessels toward the tumor and that the resulting tumor neovascularization could conceivably be prevented or interrupted by angiogenesis inhibitors. Solid and haematological tumors consist of an avascular and a subsequent vascular phase. Assuming that this depends on the release of angiogenic factors, acquisition of angiogenic capability can be seen as an expression of progression from neoplastic transformation to tumor growth and metastasis. Beginning in the 1980's, the biopharmaceutical industry began exploiting the field of antiangiogenesis for creating new therapeutic compounds for modulating new blood vessels in tumor growth. In 2004, Avastin (Bevacizumab), a humanized anti-VEGF monoclonal antibody, was the first angiogenesis inhibitor approved by the Food and Drug Administration for the treatment of colorectal cancer. At present, it has been estimated that over 20,000 cancer patients worldwide have received experimental form of antiangiogenic therapy. This book offers a historical account of the relevant literature. It also emphasizes the crucial and paradigmatic role of angiogenesis as a biological process and the significance of antiangiogenic approach for the treatment of tumors.

Neovascularization inhibitors. --- Neovascularization. --- Tumors -- Blood-vessels -- Growth. --- Tumors. --- Tumors --- Neovascularization --- Neovascularization inhibitors --- Cardiovascular Physiological Processes --- Growth Inhibitors --- Metaplasia --- Metabolic Phenomena --- Antineoplastic Agents --- Growth Substances --- Diseases --- Science --- Physiological Effects of Drugs --- Pathologic Processes --- Therapeutic Uses --- Natural Science Disciplines --- Cardiovascular Physiological Phenomena --- Phenomena and Processes --- Pharmacologic Actions --- Circulatory and Respiratory Physiological Phenomena --- Disciplines and Occupations --- Pathological Conditions, Signs and Symptoms --- Chemical Actions and Uses --- Chemicals and Drugs --- Neoplasms --- Angiogenesis Inhibitors --- Angiogenesis Modulating Agents --- Neovascularization, Physiologic --- Neovascularization, Pathologic --- Research --- Metabolism --- Medicine --- Health & Biological Sciences --- Oncology --- Blood-vessels --- Growth --- Blood-vessels. --- Treatment. --- Cancer --- Tumours --- Medicine. --- History. --- Cancer research. --- Oncology. --- Pathology. --- Cell biology. --- Biomedicine. --- Cancer Research. --- History of Science. --- Cell Biology. --- Pathology --- Cysts (Pathology) --- Oncology  . --- Cytology. --- Cell biology --- Cellular biology --- Biology --- Cells --- Cytologists --- Disease (Pathology) --- Medical sciences --- Medicine, Preventive --- Annals --- Auxiliary sciences of history --- Cancer research

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Angiogenesis plays a key role in human physiology and pathophysiology. While necessary for tissue growth and development, uncontrolled angiogenesis plays a role in the progression of certain tumors as well as atherosclerosis. Lack of angiogenesis may be the basis of myocardial ischemia and stroke. Knowledge on the mechanisms of angiogenesis is growing very rapidly, and may lead to important drugs for therapy of a variety of clinical disorders. Experts from around the world have contributed a vast array of data on different aspects of angiogenesis in this volume edited by Professors Mehta and Dhalla. This information will be of immense help to basic scientists, clinicians and those involved in drug development.

Angiogenesis inducing agents. --- Neovascularization -- Therapeutic use. --- Neovascularization, Pathologic. --- Neovascularization. --- Neovascularization --- Metaplasia --- Biological Science Disciplines --- Cardiovascular Physiological Processes --- Growth Substances --- Natural Science Disciplines --- Pathologic Processes --- Cardiovascular Physiological Phenomena --- Physiological Effects of Drugs --- Disciplines and Occupations --- Circulatory and Respiratory Physiological Phenomena --- Pharmacologic Actions --- Pathological Conditions, Signs and Symptoms --- Phenomena and Processes --- Chemical Actions and Uses --- Diseases --- Chemicals and Drugs --- Neovascularization, Pathologic --- Physiology --- Angiogenesis Modulating Agents --- Neovascularization, Physiologic --- Human Anatomy & Physiology --- Health & Biological Sciences --- Anatomy --- Therapeutic use --- Blood-vessels. --- Cardiovascular system. --- Circulatory system --- Vascular system --- Angiology --- Vasculature --- Medicine. --- Cancer research. --- Human physiology. --- Molecular biology. --- Cardiology. --- Proteins. --- Stem cells. --- Biomedicine. --- Human Physiology. --- Cancer Research. --- Receptors. --- Molecular Medicine. --- Stem Cells. --- Blood --- Cardiovascular system --- Circulation --- Oncology. --- Cell receptors. --- Colony-forming units (Cells) --- Mother cells --- Progenitor cells --- Cells --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Cell membrane receptors --- Cell surface receptors --- Receptors, Cell --- Binding sites (Biochemistry) --- Cell membranes --- Proteins --- Tumors --- Heart --- Internal medicine --- Human body --- Health Workforce --- Proteins . --- Molecular biochemistry --- Molecular biophysics --- Biochemistry --- Biophysics --- Biomolecules --- Systems biology --- Proteids --- Polypeptides --- Proteomics --- Cancer research --- Cancer. --- Medicine --- Biology --- Cancer Biology. --- Biomedical Research. --- Stem Cell Biology. --- Research. --- Biological research --- Biomedical research --- Cancers --- Carcinoma --- Malignancy (Cancer) --- Malignant tumors