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Invasive fungal diseases have increased many fold over the past 50 years. Current treatment regimens typically require prolonged administration of antifungal medications that can have significant toxicity. Moreover, our present potent antifungal armamentarium fails to eradicate fungal pathogens from certain compromised hosts. Additionally, invasive fungal diseases continue to have unacceptably high mortality rates. A growing body of work has focused on the utility of vaccines and/or immunotherapy as a powerful tool in combating mycoses, either for the active treatment, as an adjuvant, or in the prevention of specific fungal pathogens. Also, it is growing the interest over new drugs development as second choice for treatment when traditional chemotherapy fail. This Research Topic will detail the exciting progress in developing vaccines, immunotherapy and new drugs for fungi.

antifugal drugs --- vaccine --- peptide --- antibody --- virulence --- fungi --- immunotherapy --- humanized antibody --- mycosis --- cell biology

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The history of mankind has been shaped by infections, more than by war and famine together. At the same time, however, the development of society has had an equally important effect on human diseases. The emergence of agriculture, urban societies and high population densities has been proven to be crucial for the spread of pathogens, and thus human action is currently the single most important driver of infectious epidemiology. Even today, where once major killers such as poliomyelitis have been eradicated, new pathogens are appearing as result of human activity. One such group of pathogens are the fungi, whose emergence is mainly due to modern medical practices. Fungal microorganisms, from yeasts colonizing the skin or mucosa, to molds from soil or water, are usually harmless in the context of normal host responses. However, the success of chemotherapy, as well as the AIDS pandemia, has led to immune deficiencies in a significant segment of the patient population, and the extensive use of intravenous catheters has provided a way of access for microorganisms which otherwise would find difficult to infect the host. As a result, a yeast such as Candida is now on the 4th place on the list of the most frequent sepsis agents, whereas infection with the mold Aspergillus is increasing in incidence and it is one of the most feared complications in patients with hematological malignancies.

Mycoses --- Pathogenic fungi. --- Immunological aspects. --- Fungi, Pathogenic --- Fungi --- Pathogenic microorganisms --- Medical mycology --- Fungal diseases --- Fungal infections --- Fungous diseases --- Mycosis --- Mycotic diseases --- Mycotic infections --- Immunology. --- Microbiology. --- Emerging infectious diseases. --- Medical Microbiology. --- Infectious Diseases. --- Emerging infections --- New infectious diseases --- Re-emerging infectious diseases --- Reemerging infectious diseases --- Communicable diseases --- Microbial biology --- Biology --- Microorganisms --- Immunobiology --- Life sciences --- Serology --- Medical microbiology. --- Infectious diseases.

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Mycoses. --- medical mycology --- Mycoses --- Fungal Diseases --- Fungal Infections --- Fungus Infections --- Fungus Diseases --- Disease, Fungal --- Disease, Fungus --- Diseases, Fungal --- Diseases, Fungus --- Fungal Disease --- Fungal Infection --- Fungus Disease --- Fungus Infection --- Infection, Fungal --- Infection, Fungus --- Infections, Fungal --- Infections, Fungus --- Fungal diseases --- Fungal infections --- Fungous diseases --- Mycosis --- Mycotic diseases --- Mycotic infections --- Medical mycology --- Biology --- Pathology

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This book provides up-to-date information on immunogenetics of fungal diseases in the context of primary and acquired immunodeficiencies. Different aspects of this emerging field are covered, including epidemiology of fungal diseases, innate and adaptive antifungal immunity, and the role of immunogenetics in defining susceptibility to fungal diseases in primary (CMC, CGD, etc.) immunodeficiencies and hematologic patients. The available information will also be discussed in the scope of new biomarker discovery and development of immunotherapeutic approaches for personalized diagnostics and therapy. The book addresses Professors, researchers and advanced students of Medicine, Immunology, Microbiology and Genetics.

Mycoses --- Immunological aspects. --- Fungal diseases --- Fungal infections --- Fungous diseases --- Mycosis --- Mycotic diseases --- Mycotic infections --- Medicine. --- Immunology. --- Medical microbiology. --- Infectious diseases. --- Biomedicine. --- Medical Microbiology. --- Infectious Diseases. --- Medical mycology --- Microbiology. --- Emerging infectious diseases. --- Emerging infections --- New infectious diseases --- Re-emerging infectious diseases --- Reemerging infectious diseases --- Communicable diseases --- Immunobiology --- Life sciences --- Serology --- Microbial biology --- Biology --- Microorganisms

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Mycoses. --- Veterinary mycology. --- Fungous diseases in animals --- Medical mycology --- Veterinary microbiology --- Fungal diseases --- Fungal infections --- Fungous diseases --- Mycosis --- Mycotic diseases --- Mycotic infections --- Micosi --- Micologia veterinària --- Malalties fúngiques en els animals --- Micologia animal --- Microbiologia veterinària --- Infeccions fúngiques --- Infeccions produïdes per fongs --- Malalties fúngiques en l'home --- Malalties produïdes per fongs --- Malalties infeccioses --- Aspergil·losi --- Candidiasi --- Dermatomicosi --- Fongs patògens --- Medicaments antifúngics --- Micologia mèdica